February 2022 in “Obstetrics and gynaecology cases - reviews” This case report highlights the diagnostic and management challenges of polycystic ovary syndrome, especially in young women with metabolic complications like type 2 diabetes.
29 citations
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February 2019 in “Environment international” This study found that higher prenatal and early childhood lead exposure may be associated with delayed pubertal development in girls, but not in boys, in Mexico City.
54 citations
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November 1995 in “The Journal of Clinical Endocrinology & Metabolism” In this study, females with 5 alpha-reductase-2 deficiency exhibited decreased body hair, normal sebum production, and delayed menarche, suggesting a role for DHT in hair growth and menstrual function.
May 1999 in “Medicine & Science in Sports & Exercise” This case report discusses an elite female gymnast who experienced delayed menarche likely due to exercise-associated amenorrhea and diagnosed wrist conditions, recommending a treatment of reduced weight-bearing and dietary review.
5 citations
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May 2023 in “Science of the total environment” This study observed that higher PFAS concentrations during adolescence were linked to later pubertal development and lower estradiol levels in females, but not in males, potentially due to PFAS excretion with menstrual fluid.