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      community How are you using topical melatonin?

      in Treatment  1 upvotes 2 years ago
      The user is experimenting with topical melatonin for hair loss by dissolving melatonin tablets in a solution, but is having trouble with dissolution and is curious about others' methods of application and any effects on energy levels. They mention considering mixing with minoxidil but have not done so, and suggest that melatonin is best used at night.

      community Targeting multiple AGA mechanisms with commonly available substances

       4 upvotes 7 years ago
      The conversation discusses using a multimodal approach to treat androgenic alopecia, including substances like gamma-linolenic acid, DHA, sulforaphane, melatonin, cetirizine, astaxanthin, fisetin, apigenin, curcumin, limonene, genistein, and berberine. Users also mention using ketoconazole, minoxidil, and low-level laser therapy (LLLT) as part of their hair loss treatment regimens.

      community JXL082 is not PP405 and Everychem followed the wrong lead

       41 upvotes 1 year ago
      JXL082 is not the same as PP405, leading to a halt in sales and a plan to synthesize the real PP405. There is skepticism about the safety and effectiveness of JXL082 and PP405, with concerns about patent issues and the long-term impact on hair growth.

      community Anyone tried/trying alfatradiol

       5 upvotes 2 months ago
      The conversation discusses using alfatradiol, a weaker estrogen, as a treatment for hair loss, with some users sharing their experiences and challenges in obtaining it. One user mentions using a topical solution containing alfatradiol, cetricin, caffeine, and melatonin, noting no significant hair growth but stabilization.

      community how do u guys apply minxoidil if you have long hair.

      in Minoxidil  30 upvotes 1 month ago
      Applying minoxidil with long hair can be challenging due to its oily appearance, but users suggest methods like using a topical applicator, parting hair, or applying to damp hair. Some prefer oral minoxidil for ease, while others use foam or adjust application techniques to target the scalp effectively.

      community PP405 (Non) Update - Feb 2025

       36 upvotes 1 year ago
      The conversation discusses the delay in the PP405 Phase 2 study results, now expected by the end of 2025, and skepticism about research practices. There is also mention of optimism for Amplifica's AMP303 and a topical treatment in early testing.

      community What solution to use for RU58841?

       1 upvotes 3 years ago
      The post is about using different solutions for RU58841, a treatment for hair loss. The user is asking for opinions on the effectiveness of different vehicles and dosages.

      community Did someone make his own Xyon Gel liposomal with Pyrilutamide ?

       4 upvotes 3 years ago
      Creating a liposomal gel with Pyrilutamide for hair loss to reduce systemic effects, similar to Xyon's gel. The discussion includes concerns about ingredient sourcing and the benefits of targeted topical treatments.

      community Any chemists want to manufacture PP405 / JXL069? (Steps inside)

       89 upvotes 10 months ago
      The conversation discusses the synthesis and potential use of JXL069 and PP405 for hair loss treatment, with skepticism about their effectiveness and concerns about safety. Users mention that JXL069 has shown no results in hair growth, and there is confusion about its identity and effectiveness compared to PP405.

      community If sea salt spray makes thinning worse, then what?

       7 upvotes 1 year ago
      Sea salt spray may not be ideal for thinning hair, and alternatives like texture powder, thickening tonic, and styling clay are suggested for volume without damage. Some users recommend thickening sprays or mousse for a fuller appearance, while others suggest considering medication for hair loss.

      community Hair texture very thin anything that would help long hair to thicken?

       4 upvotes 3 years ago
      The user is seeking ways to thicken their fine, thin hair and is considering treatments like spironolactone, minoxidil, and microneedling. They are currently using oral spironolactone, topical minoxidil, and ketoconazole shampoo, and are exploring additional options like alfatradiol and adjusting their treatment regimen.

      community Solvent for topical fin with low absorption

       2 upvotes 2 years ago
      The conversation is about using distilled water as a solvent for topical finasteride to reduce systemic absorption. The user is considering avoiding ethanol and propylene glycol to achieve this.

      community Y'all, we have got to come to a consensus on the specifics of microneedling.

       27 upvotes 4 years ago
      Microneedling can promote hair growth, but there is uncertainty about the best practices, including needle length, device, and session frequency. Users discuss using needle lengths between 0.5mm and 1.5mm, with some experiencing pinpoint bleeding, and emphasize the need for more reliable resources and guidelines.

      community What is the deal with "longitudinal partial follicular unit transplantation"

       3 upvotes 6 years ago
      Longitudinal partial follicular unit transplantation involves extracting part of the donor follicular unit, allowing the donor area to maintain hair production and potentially increasing transplant yield. The conversation questions if this method is practiced in clinics or remains theoretical, and whether it relates to hair cloning or multiplication.

      community Why are we using 1.5mm for microneedling? Evidence says we don't need to.

       39 upvotes 4 months ago
      Shorter microneedle lengths, like 0.5mm, may be more effective and safer for hair regrowth than longer ones, such as 1.5mm, which can cause more pain and risk. Users report success with various regimens, including minoxidil, finasteride, and other topicals, alongside microneedling.

      community When to Start Hair Loss Routine with a Wedding coming up in 5.5 months.

      in Minoxidil  9 upvotes 1 year ago
      The conversation is about starting a hair loss treatment routine before a wedding in 5.5 months. The suggested treatments include topical Minoxidil, a red light cap, microneedling, and possibly supplements, but opinions vary on whether it's too late to start, with some recommending using hair fibers for the wedding.

      community Switching to oral minoxidil...

      in Minoxidil  3 upvotes 5 months ago
      OP plans to switch from topical to oral minoxidil due to limited results and is advised to overlap both for a few weeks before discontinuing the topical. Oral minoxidil may be more effective for non-responders to topical treatment.

      community How do I layer multiple treatments?

      in Treatment  2 upvotes 2 years ago
      The user asks about the order and compatibility of using topical minoxidil, stemoxydine, The Ordinary natural moisturizing factors + HA for scalp, RU58841, and Nioxin system 2 leave-in treatment. They seek advice on layering these hair loss treatments.

      community What are good hair transplant surgeons in SoCal area, preferably around Orange County?

       2 upvotes 1 month ago
      A user is seeking recommendations for hair transplant surgeons in Southern California, specifically around Orange County, and is considering options like Dr. Ken Williams, Dr. Sean Behnam, and Dr. Amir Yazdan. The user has been using finasteride and minoxidil for over 3.5 years and is looking for a cost-effective transplant option, preferring local procedures due to limited vacation days.

      community How often to microneedle for optimal results

      in Microneedling  10 upvotes 1 year ago
      Microneedling for hair loss is discussed, with users suggesting different frequencies and needle lengths, such as 1.5mm every 3 to 6 weeks or 1.0mm weekly. Some users recommend less frequent sessions to avoid scalp damage and soreness.

      community finasteride vs "natural" DHT blockers

       10 upvotes 4 years ago
      The conversation discusses challenges in obtaining finasteride in the Netherlands and explores alternatives like natural DHT blockers and topical finasteride. Suggestions include consulting different doctors or dermatologists and considering cost-effective options like cutting higher-dose tablets.