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GlossaryVitamin D Analogues (Vitamin D Derivatives)

synthetic compounds mimicking natural Vitamin D effects in treatments

Vitamin D Analogues, also known as Vitamin D Derivatives, are synthetic compounds designed to mimic the effects of natural Vitamin D in the body. They are often used in medical treatments to regulate calcium and phosphate metabolism, and are particularly useful in managing conditions like psoriasis and certain types of alopecia, where they help modulate the immune response and promote healthy skin and hair growth.

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community My personal experience/observations fighting AGA seriously for 5 years

in Treatment 43 upvotes 2 weeks ago

Minoxidil with alcohol and propylene glycol was more effective than non-alcohol versions, and RU58841 worked best in a non-water-based solution. Oral finasteride showed better results than topical, despite side effects; microneedling and tretinoin worsened hair loss, and PRP was only helpful when younger.

community Anyone else realize how many younger guys are balding?

in Chat 262 upvotes 2 months ago

Many younger men are experiencing hair loss due to genetics, diet, stress, and lifestyle changes. Treatments like finasteride and minoxidil are mentioned, with some users noting improvements.

community 1 year on fin. No results. I give up.

in Finasteride/Dutasteride 43 upvotes 2 years ago

A user who has been taking finasteride, minoxidil, and microneedling for one year with no results, and the replies discuss other treatments, including dutasteride, which is feared due to potential side effects.

community DIY treatment... Shedding completely stopped after 1.5 yrs

in Treatment 249 upvotes 2 years ago

Vitamin C mixed with shampoo stopped shedding and promoted hair regrowth after 1.5 years. Both the person and their wife experienced significant hair loss reduction with this method.

community Nandrolone Replacement Therapy

in Treatment 41 upvotes 1 year ago

A user discusses starting nandrolone replacement therapy to stop hair loss and improve hair health, noting its benefits over finasteride. They report halted hair loss, improved skin, increased muscle, and a calm mood after three weeks.

community NootBro Recommendations… How Do We Feel

in Research/Science 9 upvotes 6 months ago

The conversation is about hair loss treatments, specifically a stack including topical Ashwagandha, Copper Peptide, Gotu Kola, Ketoconazole, and PDA. One user found Topical and Sub-Q GHK-CU effective.

community Soo.. uhh.. one year... wondering when Dutasteride is going to stop hair loss

in Finasteride/Dutasteride 132 upvotes 1 year ago

User has been on finasteride and switched to Dutasteride 6 months ago, using minoxidil, tretinoin, microneedling, and RU-58841, but still experiencing hair loss. Advice given includes waiting 6-18 months for Dutasteride results and checking if it's definitely MPB.

community Six months of only Dermarolling

in Progress Pictures 157 upvotes 1 year ago

User tried dermarolling for hair loss and shared progress pictures. Some suggest adding finasteride and minoxidil, while others debate effectiveness and frequency of dermarolling.

community M19 shed after 1yr on dutasteride

in Finasteride/Dutasteride 23 upvotes 2 months ago

A 19-year-old male experienced hair shedding after one year on dutasteride and is considering adding topical minoxidil despite scalp itching. Users suggest continuing dutasteride, maintaining a consistent hair routine, and possibly increasing minoxidil dosage.

community Tretinoin, any good, what’s your experience

in Research/Science 21 upvotes 6 months ago

The conversation discusses using tretinoin for hair loss and skincare. Users share experiences, noting tretinoin's effectiveness in combination with minoxidil for hair and its proven benefits for anti-aging skincare.

community Giving up on ever feeling comfortable in my body

in Update 80 upvotes 3 years ago

The user has been using finasteride, dutasteride, and RU58841 for hair loss without success and feels extremely uncomfortable with their appearance, including being bald and short. They express deep unhappiness and social isolation. Suggestions from others include adopting stoicism, focusing on personal development, considering a hair system, improving fashion, working out, and seeking therapy for mental health.

community Using topical vitamin D, does it make sense?

in Chat 6 upvotes 2 years ago

Topical Calcipotriol (vitamin D derivative) may help with hair regrowth, especially for alopecia areata. The user wonders if adding classic vitamin D to lotions like Minoxidil could have a similar effect.

community Please take a vitamin & hormone test

in Chat 256 upvotes 1 week ago

Checking vitamin and hormone levels is important for addressing hair loss, as deficiencies in vitamin D, zinc, and iron can affect hair growth. Treatments like finasteride, minoxidil, and vitamin supplements are used, but addressing deficiencies is crucial for effectiveness.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 97 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community Ultimate Hairloss Flowchart (for beginners)

in Treatment 247 upvotes 1 year ago

The conversation discusses a hair loss flowchart for beginners, with mixed opinions on its effectiveness. Treatments mentioned include minoxidil, finasteride, dutasteride, microneedling, and vitamins.

community My Testosterone is less than 1/3rd In 7 Months since I took Finasteride!

in Finasteride/Dutasteride 113 upvotes 1 year ago

A user experienced a significant drop in testosterone levels after taking finasteride, leading to side effects like low libido and muscle mass loss. Despite its effectiveness for hair, the user decided to stop finasteride due to its impact on hormones, preferring to be bald.

community Does whey protein and creatine aggravate hair loss?

in Research/Science 82 upvotes 1 year ago

The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.

community Vitamin C and hair growth PH levels

in Product 31 upvotes 2 years ago

The conversation is about using vitamin C and Magnesium L-Threonate for hair growth by reducing DHT binding to dermal papilla cells. The original post about vitamin C's pH levels and sebum control was possibly removed by a moderator.

community Tretinoin for better Minoxidil response

in Treatment 11 upvotes 3 years ago

The conversation is about using tretinoin to improve the response to Minoxidil for hair loss treatment. No specific protocol for tretinoin application is provided.

community Pattern hair loss could be due to gut bacteria

48 upvotes 4 years ago

Feeding bacteria-free mice with Lactobacillus murinus worsened hair loss, but a regular diet with biotin stopped it. The conversation suggests gut bacteria and diet may influence hair loss, with some skepticism and discussion about other factors like DHT and genetics.

community ~5 months topical minoxidil + oral finasteride results (swipe images). Slacked with minoxidil this past month, trying to wean off anyways. My last update because I’m hopping off fin and switching to RU in a few weeks (nothing to do with fin efficacy, just experimenting).

in Progress Pictures 145 upvotes 4 years ago

The user experienced significant hair thickening after using topical minoxidil and oral finasteride for about 5 months and is considering switching from finasteride to RU58841. Other users encourage the original poster to continue the current treatment due to the positive results.

community Minoxidil, microneedling and buying tretinoin from Germany

in Minoxidil 1 upvotes 2 months ago

The conversation discusses using minoxidil with microneedling and considering tretinoin to enhance hair growth, especially for those who are weak responders to minoxidil. It also explores the potential of using tazarotene, a stronger retinoid, to boost minoxidil's effectiveness and addresses purchasing tretinoin from Germany.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 743 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Redensyl Megathread !!!!

44 upvotes 5 years ago

Redensyl, which is a topical alternative to Minoxidil for hair loss. It may have advantages such as not making the hair greasy and lasting longer after discontinuing use than minoxidil. There are some positive reports from users, but also some negative ones, so it's unclear how effective this treatment will be in comparison to Minoxidil and other treatments like Finasteride or RU58841.

community M26 - 9 months after hair transplant! AMA

in Transplants 624 upvotes 5 years ago

A user who underwent a hair transplant in Istanbul to reduce balding, and the discussion of various treatments such as finasteride and growth hormone for preventing further hair loss.

community Creatine made all my high DHT symptoms return

in Research/Science 78 upvotes 1 month ago

Creatine may increase DHT levels, potentially causing symptoms like acne, oily hair, and hair shedding. Users report mixed experiences, with some avoiding creatine due to hair loss concerns and others seeing no impact.

community It is said that minoxidil decreases collagen production. Any anecdotes here that have quit minoxidil and got better skin as a result?

in Minoxidil 9 upvotes 1 year ago

Minoxidil is discussed for its potential to decrease collagen production, with users sharing experiences about skin improvement after stopping its use. Some mention using it on their face for beard growth.

community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

in Female 53 upvotes 1 year ago

A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

community New study: Vitamin D counteracts DHT in mice and in human hair organ culture and hair cells

in Research/Science 129 upvotes 1 month ago

Vitamin D may counteract DHT and help with hair growth, as seen in mice and human hair cultures. Some users discuss using Vitamin D, magnesium, and other supplements for hair health, while others humorously note the success in mice.

community Does vitamin D deficiency actually cause hair loss? Has anyone actually grew back hair after fixing vitamin d levels?

in Chat 65 upvotes 2 months ago

Vitamin D deficiency can contribute to hair loss, but it is not the sole cause, and supplementation may not always resolve the issue. Treatments like finasteride and minoxidil are recommended for hair regrowth, with vitamin D and other supplements providing additional support.