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Glossary Tissue Damage

harm to body's tissues affecting function and structure

Tissue damage refers to harm or injury inflicted on the body's tissues, which can include skin, muscles, nerves, and internal organs. This damage can result from various causes such as physical trauma, infections, chemical exposure, or autoimmune reactions. In the context of hair and alopecia, tissue damage to the scalp can disrupt hair follicles, potentially leading to hair loss.

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community Could microneedling for the next 5 years cause any permanent damage?

in Microneedling 22 upvotes 3 years ago

Microneedling for hair loss and its potential long-term effects. Some users believe it can cause fibrosis and scar tissue if done too frequently or deeply, while others claim it has improved their hair loss when done correctly. There is limited scientific research on the topic.

community Injured temple with derma rolling

in Microneedling 2 upvotes 1 year ago

OP injured their temple using derma rolling and tretinoin, causing peeling and potential hair follicle damage. Users suggest the injury might be permanent, possibly resulting in scar tissue where hair won't grow.

community I need some guidance...

6 years ago

A user experienced hair thinning due to traction alopecia from using Murray's Beeswax and is considering treatments like minoxidil and finasteride to reverse the damage. Another user suggests consulting a hair specialist, as the hair may not regrow if scar tissue has formed.

community Does microneedling damage scalp?

in Research/Science 12 upvotes 2 years ago

Microneedling does not prevent future hair transplants, but some surgeons report the skin becomes "harder" in treated areas. There is no clear evidence to confirm this effect.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

67 upvotes 11 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community microneedle, any long term users damage?

in Microneedling 35 upvotes 2 years ago

Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

community Serious question, is there nothing that can be done if Dutasteride doesn’t help to stop my hair loss?

60 upvotes 4 years ago

A 25 year old male who has been using finasteride and dutasteride for two years to treat his hair loss, with no success. Other treatments such as oral minoxidil, topical anti-androgens, RU58841, latanoprost, topical estrogen, CB 03 01, microneedling, keto 2% shampoo, vitamin D, Omega 3, B vitamins and probiotics were discussed.

community Did anyone here have an HAIR TRANSPLANT after Microneedling?

3 upvotes 1 year ago

The conversation discusses concerns about microneedling potentially causing damage before a hair transplant, with users sharing their experiences and techniques. Specific treatments mentioned include using a dermapen at various depths and speeds, with some users advising against self-treatment.

community Is microneedling still worth it if I’m on oral minoxidil?

in Microneedling 21 upvotes 11 months ago

Microneedling may still be beneficial for those on oral minoxidil due to its effects on tissue repair and blood flow, not just absorption. Some users report mixed results, and the effectiveness of combining microneedling with oral treatments remains debated.

community Does dermarolling actually work?

in Microneedling 30 upvotes 1 year ago

Microneedling's effectiveness for hair growth is debated, with some users reporting positive results when combined with Minoxidil, while others express concerns about potential skin damage and infections. Tretinoin is suggested as an alternative to enhance Minoxidil absorption.

community A Study I came along by mistake researching (Dutasteride +Pumpkin seed oil ) for every other day use.

16 upvotes 3 months ago

Alternating Dutasteride with pumpkin seed oil may protect the spleen from damage caused by Dutasteride. Pumpkin seed oil's antioxidants help counteract oxidative stress and immune suppression.

community Blocking dht should bring it back. So why does fin mostly just hold the line?

17 upvotes 3 months ago

Finasteride mainly prevents further hair loss by blocking DHT but doesn't reverse existing damage, while minoxidil can promote regrowth by waking dormant follicles. Ketoconazole helps with inflammation, but none of these treatments can reverse fibrosis or structural changes around hair follicles.

community What Are the Technicalities of Curved Hair Transplantation?

4 upvotes 5 months ago

Curved hair transplantation requires specialized tools and techniques to avoid damaging hair follicles, with modified FUE being the preferred method. Proper extraction and implantation angles are crucial to prevent complications like keloids and sterile folliculitis.

community Can pp405 revive dead follicles for long time bald people? Are those even dead? After 10+ years bald

47 upvotes 1 year ago

PP405 may revive dormant hair follicles but is unlikely to help with long-term baldness where follicles are replaced by scar tissue. It is seen as a potential adjunct to treatments like minoxidil and finasteride, but its effectiveness on deeply fibrotic or scarred areas is doubtful.

community Are Derma Rollers Actually Harmful in the Long Run?

in Microneedling 40 upvotes 1 year ago

Derma rollers may cause scarring alopecia, leading some to prefer dermastamps or dermapens for microneedling. Combining minoxidil with microneedling is effective, but proper technique and healing time are essential to prevent damage.

community Why not move miniaturized hair follicles somewhere else to treat them? Alternative to hair cloning?

4 upvotes 1 year ago

Exploring the idea of transplanting miniaturized hair follicles to healthier areas to potentially reverse hair loss, with concerns about DHT sensitivity and scar tissue formation. The conversation also humorously considers using mice for hair growth experiments.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community People who don’t microneedle, why?

146 upvotes 11 months ago

Microneedling is often combined with minoxidil for hair growth, but concerns about scalp damage, pain, and effectiveness deter some users. Alternatives like finasteride, dutasteride, tretinoin, and laser treatments are preferred by others.

community Almost 7 months on Dut + Oral min + Keto & Dermarroller and hair is looking worse than ever

7 upvotes 4 years ago

A user is experiencing worsening hair loss despite using dutasteride, oral minoxidil, ketoconazole, and dermarolling. They are advised to reduce dermarolling frequency and depth to avoid damaging hair follicles.

community How can I tell if I have scarring from dermastamping?

10 upvotes 3 weeks ago

The user is concerned about potential scarring from using a 1.5mm dermastamp for hair loss treatment and is advised to use shallower depths (0.5-0.75mm) and reduce frequency to avoid damage. They also use topical minoxidil and finasteride, and plan to stop stamping temporarily to assess changes.

community Can topical Minoxidil use backfire if you’re a non-responder?

1 upvotes 3 months ago

The user has been using finasteride successfully to stop hair shedding and is considering using topical minoxidil for regrowth but is concerned about being a non-responder and potential negative effects. They are cautious about using oral minoxidil due to past heart issues and are exploring other methods like tretinoin cream and dermarolling, though they worry about possible skin damage.

community Microneedling at .25 everyday before applying Min

in Minoxidil 26 upvotes 1 year ago

Daily microneedling at 0.25mm before applying minoxidil is debated, with some suggesting weekly microneedling is safer and more effective. Concerns include potential skin damage and systemic absorption, while alternatives like tretinoin are considered safer for enhancing minoxidil absorption.

community microneedling efficacy for male pattern baldness?

in Microneedling 14 upvotes 4 months ago

Microneedling, when combined with finasteride and topical minoxidil, can enhance hair regrowth for male pattern baldness, especially at the temples. Users report varying success with needle depths between 0.5mm and 1.5mm, with stamps preferred over rollers to minimize scalp damage.

community Verteporfin Phase 1 Human Clinical Trial In The Works - Research

92 upvotes 1 year ago

Verteporfin is being discussed for its potential to regrow hair and heal scars, possibly aiding hair transplants or replacing them. Some users are skeptical about its effectiveness, while others suggest combining it with microneedling for better results.

community My Idea for a possible new hairloss treatment

53 upvotes 6 years ago

Exploring a potential hair loss treatment using the enzyme AKR1C2 to locally reduce DHT levels. Challenges include enzyme delivery through the skin and high production costs, with gene therapy or stem cells suggested as future alternatives.

community 1.5 years finasteride only, it’s legit

in Progress Pictures 450 upvotes 1 year ago

The user experienced thicker and healthier hair after 1.5 years of using finasteride daily, with no side effects. They plan to start minoxidil to enhance regrowth.

community Why does MPB only affect the scalp

in Research/Science 14 upvotes 1 year ago

Male pattern baldness (MPB) may be influenced by androgen receptors in scalp hair follicles and potentially poor blood flow. Transplanted hair is not immune to DHT, and factors like inflammation and scalp tension might also contribute to hair loss.

community Deoxyribose sugar gel worked just as well as minoxidil

in Research/Science 18 upvotes 1 year ago

A deoxyribose sugar gel may work as well as minoxidil for hair regrowth by boosting blood supply to hair follicles. Some users discuss combining it with minoxidil and cetrizine, but caution is advised due to potential risks and lack of consistent results.

community Does anyone know the main driver for the efficacy of micro-needling?

5 upvotes 1 year ago

Microneedling may enhance hair loss treatment by increasing the effectiveness of topical minoxidil, especially for those lacking the necessary enzyme to activate it. It might also work by triggering growth factors and improving topical absorption.

community What's the general consensus on microneedling here?

in Microneedling 21 upvotes 2 years ago

The conversation discusses microneedling for hair loss, focusing on optimal needle depth and frequency. Users report varying practices, with some using Minoxidil after microneedling and others suggesting different depths and frequencies based on personal tolerance.