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      community PP405 Update and My Take on Pelage

      in Research/Science  86 upvotes 10 months ago
      Pelage Pharmaceuticals raised $120M for their hair loss treatment, PP405, showing strong investor confidence despite limited data. There is skepticism about its efficacy and long-term effects compared to treatments like GT20029.

      community Clascoterone Scalp 2 Results in July?

       4 upvotes 2 months ago
      The conversation discusses the anticipation of clascoterone scalp treatment results for hair loss, with concerns about its availability and high cost. Users express hope for positive outcomes and affordable access.

      community inactive ingredients of Sandoz Finasteride 5mg compared too Proscar and Propecia?

       3 upvotes 11 years ago
      The conversation discusses the differences in inactive ingredients between Sandoz 5mg Finasteride and Proscar/Propecia, questioning the purpose of certain additives like Docusate sodium. It seeks to determine if these differences affect the effectiveness of the treatment for hair loss.

      community Clascoterone full results 2026

       7 upvotes 2 weeks ago
      Clascoterone results are anticipated to be released in fall 2026, possibly at the EADV conference. Users express skepticism and humor about the release date.

      community fluridil (topilutamide) vs. cb-03-01 (clascoterone)

       4 upvotes 2 years ago
      The conversation is about comparing the effectiveness of fluridil and clascoterone in preventing hair loss and inquiring about their use as standalone treatments. There is a question about the concentration of the fluridil brand for efficacy.

      community Wrap it up everyone. CB-03-01 is another failed treatment

       79 upvotes 1 year ago
      CB-03-01 is considered a failed treatment for hair loss, with future hopes pinned on PP-405 and GT-20029, expected by 2030. Alternatives like hair transplants and SMP are discussed, while some users express frustration over the slow progress of treatments like Breezula.

      community RU and cetosomal minoxidil topical

       1 upvotes 7 months ago
      Mixing RU58841 with cetosomal minoxidil is discussed due to scalp irritation from ethanol PG vehicles. A mixture of the two turned bright pink when left to dry.

      community Anyone knows if koshine kx-826 has propylene glicol?

      11 months ago
      Koshine KX-826 has different versions, and the green version uses a plant-based carrier that may be less irritating for those sensitive to propylene glycol. Users report irritation with some versions of KX-826.

      community Anyone lose hair on selenium sulfide? (Selsun Blue)

       1 upvotes 10 months ago
      Selenium sulfide shampoo helped with a sore scalp but may cause hair root damage. Users experienced hair loss with selenium sulfide and ketoconazole, suggesting reducing use if hair loss occurs.

      community Propylene Glycol vs Glycerin in topical finasterside?

       2 upvotes 10 months ago
      Switching from propylene glycol to glycerin in topical finasteride may reduce systemic absorption and side effects while maintaining local scalp DHT suppression. Concerns exist about glycerin's ability to deliver the full dose to hair follicles.

      community Anyone here used spirolactone/cyproterone acetate/bicalutamide?

       4 upvotes 1 year ago
      The conversation discusses the use of spironolactone, cyproterone acetate, and bicalutamide for hair loss, with concerns about side effects like gynecomastia and depression. Topical spironolactone is considered safe for men and effective when combined with regular treatments.

      community My experience: pre-existing gyno and finasteride

       3 upvotes 7 years ago
      The conversation discusses experiences with finasteride for hair loss, particularly in relation to pre-existing gynecomastia. The original poster used finasteride but stopped after finding no change in gynecomastia size, and others shared similar concerns and experiences.

      community Counter-update: Cbum's transplant DOESNT look super good now

       223 upvotes 1 year ago
      Cbum's hair transplant is criticized for looking unnatural and not blending well, with some suggesting better results were expected given his resources. Discussions also cover the effects of steroids and finasteride on hair loss and muscle growth.

      community GHK Cu - is this the next best solution for hairloss?

       25 upvotes 7 months ago
      GHK-Cu is discussed as a potential hair loss treatment, with claims of promoting hair growth and possibly reversing gray hair, though strong clinical evidence is limited. The user also mentions using Minoxidil, red light therapy, and microneedling.

      community Clascoterone - what we have right now

       24 upvotes 6 months ago
      Clascoterone is a topical treatment for androgenetic alopecia, showing modest to moderate hair regrowth, and may be available by 2027-2028. It is considered safer than finasteride, with discussions on its effectiveness compared to RU58841 and pyrilutamide.

      community Pre-mixed RU58841 in the KB solution vs PG solution?

       4 upvotes 5 years ago
      Choosing between KB and PG solutions for applying RU58841, considering factors like scalp oiliness and absorption. Some users prefer KB for being gentler, while others use PG and recommend washing hair before application for better results.

      community Does it work? Maneup GHK-Cu hair growth serum

       10 upvotes 2 years ago
      The conversation is about the effectiveness of Maneup GHK-Cu hair growth serum, a topical treatment for hair loss. The user is considering trying it but is skeptical due to issues others have had with DIY injections of a similar substance.

      community Peptides? Men's Journal article.

       9 upvotes 2 years ago
      The conversation is about the effectiveness of peptides for hair loss and the user considering using GHK-Cu, CJC-1295, and BPC-157 for treatment.

      community Chat is this real? Compound called clascoterone

       581 upvotes 9 months ago
      Clascoterone shows promising results for hair regrowth in men with androgenetic alopecia, with potential FDA approval by 2026. It acts as a topical androgen receptor blocker, offering a new treatment option with minimal side effects compared to existing treatments like finasteride.

      community Ru + glycerin making scalp greasy . help !!

       2 upvotes 1 year ago
      The user is experiencing a greasy and dandruff-prone scalp from using RU58841 with glycerin and is seeking alternative carriers for seborrheic dermatitis. They are also using dutasteride 0.5mg.

      community The final nail in the coffin. PP405 is confirmed JXL069.

       440 upvotes 1 month ago
      PP405 and JXL069 are confirmed to be the same molecule, leading to disappointment due to poor hair regrowth results. Users express skepticism about the credibility of Pelage and the effectiveness of JXL069.

      community EssenGen 6-Plus with PG Results - 7 Weeks

       162 upvotes 10 months ago
      The user started using EssenGen 6-Plus, containing 6% minoxidil and 0.05% finasteride, along with 1% Nizoral shampoo, and reported noticeable hair growth in 7 weeks. They experienced some chest tightness but are monitoring it, and they are satisfied with the progress despite using a silicone-containing shampoo.

      community EMA is re-examining Winlevi (clascoterone at lower concentration)

       8 upvotes 1 year ago
      Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

      community Looking for real-world experiences with Kadeso

       3 upvotes 1 year ago
      A user is exploring Kadeso, a product with Capilia Longa™ for hair regrowth, and seeks real-world experiences, comparing it to Minoxidil and Finasteride. They are interested in results, timeframe, side effects, and the credibility of the product's founder.

      community Ordered copper peptides - how to apply?

      in Treatment  1 upvotes 2 years ago
      Gizzela is unsure about the dosage and frequency of copper peptides and asks if they can be used with Stemoxydine. They seek advice on applying these treatments together.

      community Spironolactone and pregnancy planning

      in Female  2 upvotes 1 year ago
      A user with AGA uses topical spironolactone 2% due to side effects from the oral form and is concerned about its use during conception and breastfeeding. They seek alternatives to prevent AGA relapse while planning pregnancy and after childbirth.