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      community Prediction: Scube3 is never coming out

      in Research/Science  6 upvotes 8 months ago
      Scube3, a potential hair loss treatment, is unlikely to be released because it was given to a startup company, Amplifica, which may go bankrupt and fail to bring the treatment to market. Amplifica is prioritizing other treatments over Scube3, which could lead to financial loss and the end of Scube3's development.

      community Is this broscience? From More Plates, More Dates

      in Research/Science  22 upvotes 8 months ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

      community Does microneedling damage scalp?

      in Research/Science  12 upvotes 8 months ago
      Microneedling does not prevent future hair transplants, but some surgeons report the skin becomes "harder" in treated areas. There is no clear evidence to confirm this effect.

      community Finasteride is Good for Heart Health!

      in Research/Science  119 upvotes 8 months ago
      Finasteride, a hair loss and prostate drug, may also benefit heart health. Some users discuss the potential negative effects of DHT on the heart and the balance between hair loss treatments and heart health.

      community Why do some have no change even on nuclear stacks ?

      in Research/Science  16 upvotes 8 months ago
      Some people see significant hair regrowth using treatments like finasteride and minoxidil, while others experience little to no improvement even with comprehensive treatment plans. Factors such as individual sensitivity to DHT may influence the effectiveness of these hair loss treatments.

      community RU58841 KB Solution vs PG + Ethanol

      in Research/Science  6 upvotes 8 months ago
      The conversation discusses the differences between KB solution and PG + Ethanol solution for RU58841 in treating hair loss. It compares the effectiveness and properties of these two solutions.

      community Spironolactone topically with a try ?!

      in Research/Science  1 upvotes 8 months ago
      A 30-year-old male is considering using dutasteride and fluridil for hair loss maintenance and is curious about the effectiveness of topical spironolactone, as he cannot take finasteride. He is also planning a hair transplant.

      community Does lowering serum prolactin lower prolactin in the scalp?

      in Research/Science  13 upvotes 8 months ago
      The conversation discusses whether not masturbating (semen retention) affects hair loss, with opinions varying but generally dismissing the idea. Some participants mention using hair loss treatments like Minoxidil, Finasteride, and RU58841, but the effectiveness and relation to prolactin levels in the scalp are debated.

      community Any other treatments to still be hopeful for?

      in Research/Science  18 upvotes 8 months ago
      The conversation discusses the potential of new hair loss treatments, with a focus on pyrilutamide, gt20029, and topical alfatradiol, and the possibility of improving their effectiveness through methods like increased concentration and microneedling. Dutasteride is also mentioned as a stronger option.

      community Any New Findings or Interesting Research?

      in Research/Science  24 upvotes 8 months ago
      The conversation is about seeking new research on hair loss treatments beyond the commonly known ones like Minoxidil and Finasteride. Additions to the list of treatments include topical caffeine, alfatradiol, fluridil, stemoxydine, and upcoming treatments like TDM-105795 and verteporfin.

      community Where is GT20029 already? Grrrr

      in Research/Science  19 upvotes 9 months ago
      The conversation is about frustration over the delay in phase 2 results for a hair loss treatment called GT20029. One user suspects the treatment may have failed.

      community Hope Medicine HMI-115 got 28M$ investment

      in Research/Science  59 upvotes 9 months ago
      Hope Medicine received a $28M investment for HMI-115, a monoclonal antibody in phase II trials for treating androgenetic alopecia. Some users are skeptical about its effectiveness, while others find the investment and trial results encouraging.

      community TDM-105795 phase 2 results are in!

      in Research/Science  28 upvotes 9 months ago
      TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

      community Does low HGH leading to hairloss?

      in Research/Science  11 upvotes 9 months ago
      The user experiencing diffuse hair loss is using various treatments including RU58841, finasteride, minoxidil with tretinoin, anti-hair loss shampoo, and microneedling, and is considering adding peptides TB500, BPC157, and GHK-Cu. They have low growth hormone levels and are questioning its impact on hair loss, while another user suggests androgenic alopecia and androgens are likely the main cause of hair loss.

      community Testosterone in Reference Range Doesn't Cause Hair Loss

      in Research/Science  51 upvotes 9 months ago
      Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

      community Topical Finasteride strength discussion

      in Research/Science  66 upvotes 9 months ago
      The conversation discusses the effectiveness of different concentrations and dosages of topical finasteride on scalp and serum DHT levels, comparing it to oral finasteride and noting the side effects seem to be fewer at lower dosages. Participants shared experiences and referenced a chart indicating similar scalp DHT reduction with 0.025% topical finasteride as with 1mg oral finasteride, but with fewer side effects.

      community Is there a consensus on a "best conditioner" to use?

      in Research/Science  12 upvotes 9 months ago
      The conversation is about finding the best conditioner for hair loss, with a mention that Ketoconazole shampoo is recommended for reversing hair loss. Users suggest that most "hair growth" conditioners are ineffective and discuss using anti-dandruff conditioners with piroctone olamine.

      community Further prolactin research....

      in Research/Science  6 upvotes 9 months ago
      HMI 115 did not work as expected for hair regrowth in humans, unlike in macaque monkeys. There is anticipation for further research on prolactin's role in hair loss, with expectations that pharmaceutical companies will likely solve this before universities.

      community Verteporfin Update with Dr Blake Bloxham

      in Research/Science  27 upvotes 9 months ago
      The conversation discusses Dr. Blake Bloxham's experiment with Verteporfin for hair loss, with one person suggesting more doctors should try it as it seems beneficial. Another comment notes that results at 4-5 months were not very impressive.