User taking 1mg finasteride daily for 2 years, wants to block more scalpDHT. Seeks reference for additional topical DHT blockers like alfatradiol and fluridil.
Hair loss treatments, specifically, discussing the effectiveness and side effects of finasteride, minoxidil, and RU58841 in various microdoses. It also includes an updated graph which provides information on how different doses affect DHT levels, scalp skin and serum androgen levels, as well as hair count.
Beard hair grown with minoxidil can become permanent because it is not sensitive to DHT, unlike scalp hair, which requires ongoing minoxidil use even with DHT blockers like finasteride or dutasteride. Dutasteride reduces scalpDHT significantly but not completely, which may explain why scalp hair still needs minoxidil for maintenance.
Factors that can cause hair loss other than DHT, such as inflammation and diet, and potential treatments like scalp massages, minoxidil, citrulline, stretches, meditation, iron sulfate/Vitamin C, Vitamin D, protein and Dutasteride.
Dutasteride potentially being more effective than Finasteride in treating hair loss due to its ability to suppress DHT levels more significantly. Dutasteride also has fewer sexual side effects compared to Finasteride.
The conversation is about creating a topical hair loss treatment with B6, zinc, and azelaic acid, which is claimed to inhibit 90% of scalpDHT. One user is skeptical about the effectiveness of this treatment and its comparison to other treatments without side effects.
Whether Finasteride can keep alive the hair gained by Minoxidil after quitting it, and why beard hairs are not as susceptible to miniaturization. It is suggested that scalp hair may be dependent on Minoxidil and that DHT could be countered with Finasteride to some extent, but there is no definitive data proving this.
Dutasteride significantly reduces scalpDHT levels and can save hair, though shedding is part of the process. Some users report success with dutasteride, while others struggle despite using it along with finasteride and oral minoxidil.
0.5mg dutasteride reduces scalpDHT more than 1mg finasteride, leading to better hair regrowth results. Users report significant improvement with dutasteride compared to finasteride.
Combining finasteride with dutasteride may have additive benefits for reducing scalpDHT, but the extent is unknown. Some users report less shedding when using both treatments, with variations in dosage and application methods.
A user is considering combining oral and topical dutasteride to lower scalpDHT more effectively and is seeking advice on this approach. They are thinking about doing a patch test on their mid scalp.
The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.
The efficacy of low doses of finasteride to reduce scalpDHT, and whether studies showing a 61% reduction are reflected in actual results. Replies discussed hair growth as an unintended consequence of minoxidil and finasteride use, as well as self-selective bias, potential side effects, and that studies measure effectiveness by hair count changes rather than DHT inhibition.
A user suggests that a .25% topical finasteride solution could reduce scalpDHT levels without affecting bloodstream DHT levels, potentially avoiding sexual side effects. They question why a 2.5% solution was chosen and if a custom .25% solution can be ordered.
Topical finasteride as a potential alternative to oral finasteride for reducing DHT levels on the scalp with fewer side effects, and other hair loss treatments such as minoxidil.
Epristeride is a selective 5 alpha reductase type 2 inhibitor that may reduce scalpDHT similarly to finasteride, with potentially fewer side effects. It is suggested that combining epristeride with finasteride or dutasteride could enhance hair loss treatment effectiveness.
The conversation is about the effectiveness and safety of using 2.5mg of Dutasteride for hair loss. Users discuss the high scalpDHT suppression rates but caution against high doses due to potential side effects and recommend consulting a doctor.
A user on finasteride for hair loss is considering topical dutasteride to further reduce scalpDHT and is using various other topicals as substitutes for minoxidil due to concerns about the safety of their cats and potential heart side effects from oral minoxidil. They are exploring whether a once-weekly application of topical dutasteride would be effective.
The conversation discusses the effectiveness of different concentrations and dosages of topical finasteride on scalp and serum DHT levels, comparing it to oral finasteride and noting the side effects seem to be fewer at lower dosages. Participants shared experiences and referenced a chart indicating similar scalpDHT reduction with 0.025% topical finasteride as with 1mg oral finasteride, but with fewer side effects.
A user on .5 mg of dutasteride for hair loss saw no improvement and is considering increasing to 2.5 mg but is unsure of its effectiveness. Another user mentioned that 2.5 mg reduces scalpDHT more and increases hair count more than .5 mg, but the cost and side effects should be considered.
The conversation is about a user considering the use of Ketoconazole 2% shampoo before showing signs of male pattern baldness (MPB) to potentially delay its onset, inspired by a YouTuber who uses the shampoo to reduce scalpDHT levels. The user's interest in this preventative measure stems from a family history of MPB.
Dutasteride Mesotherapy for hair loss is discussed, noting its potential to lower scalpDHT without side effects. Concerns include the inconvenience of injections, lack of reputable studies, and availability issues.
A 28-year-old male is experiencing hair loss despite using topical and oral Minoxidil, oral Finasteride, and recently switching to oral Dutasteride. He is considering whether to return to topical Dutasteride or add Dutasteride mesotherapy to better target scalpDHT.
Higher doses of dutasteride, such as 2.5mg, are more effective at reducing scalpDHT than 0.5mg, but are costly and inconvenient. A 1mg dose is considered a more affordable and practical option, though its efficacy is uncertain.
The conversation discusses managing hair loss and seborrheic dermatitis with treatments like minoxidil, finasteride, and saw palmetto, emphasizing the importance of scalp health and DHT reduction. The user shares personal experiences and suggests a balanced approach, combining topical treatments and lifestyle changes for effective hair regrowth.
The regimen includes using a diluted 5.5% Minoxidil / 0.025% Finasteride solution daily, microneedling weekly, and ketoconazole shampoo twice a week to minimize systemic exposure while maximizing scalpDHT reduction. The goal is to achieve hair regrowth with minimal side effects.
The conversation discusses the effectiveness of different doses of finasteride for hair loss, questioning the need for 1mg daily when 0.5mg every other day has a similar impact on scalpDHT. A humorous reply suggests exaggerated side effects.
John has experienced slight hair gains and stability over 20 years using Dutasteride, which is more effective than Finasteride in reducing scalpDHT and maintaining hair. Dutasteride at 0.5mg daily has a similar side effect profile to Finasteride, but at higher doses, it may increase the risk of sexual side effects.
The conversation is about the effectiveness of 0.25% topical finasteride compared to other concentrations and forms. Users discuss its potential for better scalpDHT reduction and fewer side effects, with some preferring topical over oral treatments.
Pyrilutamide is believed to be more effective than RU58841 and 1 mg finasteride in treating hair loss, with no systemic hormonal effects and the potential to block more than 31% of scalpDHT. It may also antagonize scalp testosterone due to its action as an androgen receptor antagonist.