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Finasteride may affect liver function and cortisol levels, potentially linking it to non-alcoholic fatty liver disease (NAFLD). More research is needed to understand this connection fully.

A user is anxious about starting finasteride for hair loss despite believing in its effectiveness. Others suggest starting with a lower dose and emphasize the low risk of side effects.

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

Increasing the sult1a1 enzyme on the scalp may improve response to topical minoxidil. The user suggests using a baking soda solution, DMSO, and tretinoin to enhance enzyme activity and minoxidil effectiveness.

Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

The conversation discusses whether dermarolling (microneedling) works with oral minoxidil for hair loss treatment. References to studies on microneedling alone and combined with minoxidil are provided.

The user is considering splitting their 5 mg oral minoxidil dose into two 2.5 mg doses and is asking about starting tretinoin on the scalp, questioning if it should be used alone initially or with topical minoxidil. They also inquire if tretinoin significantly improved their hair loss treatment.

The user has been using minoxidil and finasteride for hair loss but is now considering microneedling due to recent hairline regression. Another user reassures that derma rolling causes only slight redness, which usually heals overnight.

Discontinuing Minoxidil typically returns hair to baseline, but some believe it may go below baseline temporarily. Continuing finasteride or dutasteride is recommended.

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

This post and conversation are about using scalp slapping to increase blood flow for hair growth. One user suggests using minoxidil instead.

Peppermint oil may be beneficial for hair growth, potentially outperforming minoxidil. Users discuss its effectiveness compared to other treatments like finasteride and RU58841.

The conversation discusses microneedling for hair loss, focusing on optimal needle depth and frequency. Users report varying practices, with some using Minoxidil after microneedling and others suggesting different depths and frequencies based on personal tolerance.

High cholesterol may accelerate hair loss by reducing blood flow and increasing DHT levels. Treatments mentioned include Minoxidil, finasteride, and RU58841.

Microneedling with 0.6 mm needles combined with 5% minoxidil is more effective for hair count and thickness than minoxidil alone or with 1.2 mm needles. Biweekly microneedling at 0.6 mm depth is recommended for better results in treating androgenetic alopecia.

The user uses 1mg fin every other day, a topical solution of 5% min + 0.1% fin nightly, and seeks advice on oils for hair growth. Replies suggest oils are ineffective and recommend sticking with fin and min treatments.

JW0061 shows superior hair growth results compared to existing treatments, with significant increases in hair follicles. The Wnt/β-catenin pathway is crucial for hair growth, and JW0061 activates this pathway effectively.

The conversation is about a user trying a new hair loss treatment, Ruxolitinib, alongside their existing regimen of finasteride, minoxidil, ketoconazole shampoo, and microneedling. They plan to apply Ruxolitinib to their temples daily for 1-2 months.

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

The conversation is about using Ketoconazole shampoo for hair loss, with users discussing leaving it on the scalp for longer periods. Some users report benefits for dandruff, but there's uncertainty about its effectiveness for androgenetic alopecia (AGA).

The user is asking if caffeine topicals are effective for hair growth, noting they already use Minoxidil and finasteride. They are unsure if caffeine topicals are beneficial or a waste of money.

The conversation is about a user's one-year hair regrowth progress using 1.25mg of finasteride daily. Users are asking about the timeline of visible progress, the user's age, and whether they experienced shedding.

A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.

Minoxidil-dependent hairs fall out if minoxidil is stopped. New treatments like GT20029, FOL055, or TDM105795 might help sustain these hairs.

A user shared a positive 5-year experience with oral finasteride and minoxidil for hair loss, noting improvement and stability. Others in the conversation also reported positive results with these treatments.

A user on .5 mg of dutasteride for hair loss saw no improvement and is considering increasing to 2.5 mg but is unsure of its effectiveness. Another user mentioned that 2.5 mg reduces scalp DHT more and increases hair count more than .5 mg, but the cost and side effects should be considered.

The conversation is about a user's 26-month hair loss treatment journey using finasteride, minoxidil foam, and microneedling, with gradual improvement in their hairline. The user applied treatments consistently and adjusted the frequency of microneedling based on feedback, noting that progress can feel slow compared to others.

A user reported hair thickening and a stronger crown after using rosemary shampoo for about a year, with progress pictures as evidence. Some commenters discussed the effectiveness of natural treatments versus pharmaceutical options like Minoxidil and Finasteride.

A 27-year-old male experienced rapid hair loss after dengue fever, which activated a balding gene. The doctor suggested platelet-rich plasma treatment for hair regrowth.