FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
Finasteride may affect liver function and cortisol levels, potentially linking it to non-alcoholic fatty liver disease (NAFLD). More research is needed to understand this connection fully.
Combining finasteride and dutasteride with activities that raise testosterone may increase the risk of side effects like gynecomastia, depending on genetic predisposition and hormone levels. It's advised to check hormone levels to assess the risk.
A user is concerned about hairloss from creatine and asks for precautions, mentioning treatments like Minoxidil, finasteride, and ketoconazole shampoo. Replies vary, with some users sharing personal experiences and others dismissing the concern.
Minoxidil can preventhair follicle miniaturization, not just stimulate hair growth. Finasteride and dutasteride don't work for everyone, suggesting DHT may not be the sole cause of hairloss; hairloss could be due to multiple factors, including autoimmune conditions.
The conversation discusses six home remedies to preventhairloss: oil massage, aloe vera, onion juice, beetroot, and flaxseed. These methods aim to improve scalp health, promote hair growth, and reduce hair fall.
Mixing minoxidil with castor oil (and possibly rosemary oil) to prevent dry scalp. Concerns about whether this affects the potency or absorption of minoxidil.
The user uses finasteride, minoxidil, and ketoconazole for hairloss. They are concerned if applying moisturizer before minoxidil affects its absorption or efficacy.
The conversation discusses whether topical caffeine is effective for hairloss, with some users questioning its role due to its vasoconstrictive and vasodilative properties, while another suggests that temporary vasoconstriction might be beneficial by promoting angiogenesis. Specific treatments mentioned include caffeine shampoo, which one user believes is ineffective.
The conversation discusses a 17-year-old using finasteride to address early hair thinning, expressing pride in taking action to preventhairloss. The user emphasizes the importance of starting treatment early and shares experiences with the hairloss community.
The conversation is about foods, vitamins, and supplements to avoid to preventhairloss, specifically mentioning alcohol, Brazil nuts, smoking, and sugary foods.
Topical formulations, natural products, and CAM therapies are being used to treat Androgenic alopecia to avoid side effects of Finasteride and Minoxidil. The review covers various low-risk, alternative treatment options.
Microneedling does not prevent future hair transplants, but some surgeons report the skin becomes "harder" in treated areas. There is no clear evidence to confirm this effect.
RU58841 is used topically to preventhairloss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.
Start finasteride and minoxidil early to prevent significant hairloss and maintain styling options. Finasteride can reduce acne and improve skin appearance.
RU and Pyri block androgen receptors to preventhairloss but may also hinder hair regrowth since they prevent testosterone, which can stimulate hair growth, from binding to these receptors. The user is questioning if this understanding is correct.
The potential of using Verteporfin to preventhairloss scars and possible regrowth, with two doctors currently testing it, although the price of a 15mg bottle is expensive.
Flax seeds may block DHT and preventhairloss. Users discuss its potential benefits, with one noting it likely has negligible effects on hair but is good for the diet.
Finasteride is increasingly prescribed to young men to preventhairloss, with many users expressing regret for not starting sooner. The conversation highlights the preference for Finasteride, Dutasteride, and Minoxidil over other treatments.
A natural compound called C3A from Aronia Chokeberry can help preventhairloss by counteracting the effects of DHT. The user has been taking 50 grams of dried organic Aronia Chokeberry daily for 30 days and will update with photos in 60 days.
Imidazole drugs like ketoconazole inhibit certain enzymes and prevent DHT from binding to SHBG, increasing free DHT in the bloodstream, which may contribute to balding. The discussion questions how these drugs help with hairloss despite this effect.
User baldwarrior85 regrets not starting finasteride earlier to preventhairloss. Others share their experiences, with some having side effects and others seeing positive results from the treatment.
The post argues for teenage use of finasteride to preventhairloss, citing minimal side effects and personal success. Replies criticize the advice, highlighting potential developmental risks and questioning the safety of finasteride for teenagers.
The user has been using finasteride and minoxidil for 5 years to preventhairloss and is considering adding dutasteride for regrowth or opting for a hair transplant. Suggestions include trying dutasteride, oral minoxidil, microneedling, and possibly a hair transplant for better results.
OP experienced side effects from finasteride and is considering using RU58841 to preventhairloss during a testosterone cycle. They have also used minoxidil, Nizoral, alfatradiol, and fluridil successfully.
A user started taking 0.25mg of finasteride every other day to preventhairloss and documented their experience. Initially, they felt anxious and had headaches, but by the second week, they felt normal with no side effects or changes in hair.
The conversation discusses how many male models and celebrities likely use finasteride to preventhairloss, with some expressing surprise that it's not just good genetics keeping their hair intact. Specific treatments mentioned include finasteride and, in one query, minoxidil.