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      community Pelage have made a new post about PP405

      in Chat  17 upvotes 4 weeks ago
      PP405 aims to reactivate hair follicle stem cells to promote hair growth, but its effectiveness is debated. Some users are skeptical, citing past failures of similar treatments and questioning the company's claims.

      community Microneedle and aloe vera after?

      in Microneedling  5 upvotes 4 years ago
      The user plans to use a 1.5 mm dermapen for microneedling every 10 days and is considering applying aloe vera afterward. They also inquire about the timing for washing their hair before and after the treatment.

      community It looks like Pelage are giving hints that PP405 is a game changer

      in Chat  239 upvotes 5 months ago
      PP405 is seen as a potential breakthrough for converting vellus hairs to terminal hairs, with users expressing both hope and skepticism. It is compared to treatments like minoxidil and finasteride, with discussions on side effects and marketing concerns.

      community How do you prevent infection with derma needling / derma stamping?

       1 upvotes 1 year ago
      The conversation discusses preventing infection from derma stamping for hair loss treatment, with suggestions to reduce needle depth and consider alternatives like tretinoin. The user experienced irritation possibly from zinc chloride and stopped using the shampoo and derma stamping.

      community This shedding fase is absolutely brutal

      in Progress Pictures  181 upvotes 1 year ago
      The user is experiencing severe hair shedding despite using minoxidil, finasteride, ketoconazole shampoo, and dermarolling. They are considering changing treatments after stopping dermarolling and switching finasteride brands worsened the shedding.

      community Scalp Exohealer with RF Microneedling

       141 upvotes 4 months ago
      The conversation is about using RF microneedling with ExoHealer, along with finasteride and minoxidil, to improve hair thickness and reduce shedding. The user reports noticeable improvements in scalp texture and oiliness, with plans to consider stem cell treatments in the future.

      community Quote from Pelage (PP-405) Spokesperson...

       122 upvotes 11 months ago
      Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

      community Switching from oral to topical dut

      in Finasteride/Dutasteride  1 upvotes 7 months ago
      Switching from oral to topical dutasteride can cause shedding due to changes in DHT levels, and it's recommended to overlap both treatments to minimize this effect. Topical dutasteride may cause scalp irritation, and the user is considering dutasteride mesotherapy as an alternative.

      community Reduced excessive hair shedding

       193 upvotes 2 months ago
      Scalp microneedling with Exohealer significantly reduced hair shedding for the user. The treatment was done at Seoul Forena Clinic.

      community Anyone Try Microneedling with Exosomes/AAPE?

       2 upvotes 4 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

      community Pelage are starting phase 3 for PP405 towards the end of 2026

      in Chat  180 upvotes 7 months ago
      PP405 is moving to late-stage trials, showing potential for hair regrowth, with 31% of male patients experiencing a 20% increase in hair density. Veradermics is developing an oral minoxidil version, and there is interest in combining treatments for better results.

      community Derma roll, tretinoin, minoxidil

       3 upvotes 1 year ago
      Use tretinoin three times a week, dermaroll once a week, and apply minoxidil daily, but avoid using all three on the same day. Tretinoin is preferred over hydrocortisone and should not be used immediately after dermarolling.

      community Collagen peptides(powder) i highly recommend

       7 upvotes 1 year ago
      Collagen peptides are recommended for hair and skin benefits, with users noting improvements in hair and skin health. However, evidence on their effectiveness for hair growth is inconclusive.

      community Started Finasteride + Derma rolling

       4 upvotes 5 years ago
      The user started finasteride and derma rolling for hair loss, later switching to wet cupping therapy. They experienced initial shedding but reported thicker, healthier hair over time, using natural hair wash methods like Amla, Reetha, and Shikakai.

      community Pelage Recruiting Now for Phase 2

       11 upvotes 2 years ago
      Pelage is recruiting for phase 2 trials, showing promise for treating bald regions. The discussion highlights its potential effectiveness based on its mechanism of action.

      community Why you can still look forward to PP405 and JXL-069

       22 upvotes 1 month ago
      PP405 and JXL-069 are the same compound, but users experienced no results due to flawed application methods. The topical gel formulation of PP405 is designed to target hair follicle stem cells effectively, unlike liquid solutions that fail to penetrate deeply.

      community Hopefully a logical question regarding dermarolling.

      in Microneedling 6 years ago
      A user discusses using dermastamping for hair loss and questions the timing of applying a mixture of peppermint oil, spearmint oil, rosemary oil, and castor oil due to their anti-inflammatory effects. They wonder if waiting 10 hours after stamping would be more effective.

      community Hair follicle dermal papilla exosomes

       2 upvotes 1 year ago
      The conversation discusses using hair follicle dermal papilla exosomes for hair loss treatment. It inquires about purchasing options for this treatment.

      community Itching scalp and dandruff when i scratch it

       1 upvotes 1 year ago
      The conversation is about managing an itchy, flaky scalp, possibly due to psoriasis, and the use of a hydrating conditioner to address dryness. The user is concerned about using conditioner due to experiencing telogen effluvium.

      community topical exosomes - experimenting

       1 upvotes 6 months ago
      The conversation is about experimenting with topical exosomes for hair loss treatment, alongside microneedling, Happy Head's gel-like topical, and Ordinary's hair serum. The user also mentions the availability of treatments like latanoprost and Redensyl.

      community Red and ichy pimples/rash from applying topical minoxidil

       2 upvotes 7 months ago
      The user experienced red pimples and a rash from using topical minoxidil, possibly due to propylene glycol. Suggestions included seeing a dermatologist, switching to foam without propylene glycol, using Nizoral, and adjusting application timing.

      community Im struggling with sebderm need help

       3 upvotes 6 months ago
      The user is struggling with seborrheic dermatitis and plans to try ciclopirox olamine after finding ketoconazole too drying. They are also using finasteride daily.

      community The use of peptides to enhance hair growth from wounding

       4 upvotes 9 years ago
      The conversation discusses using peptides BPC-157 and TB-500, combined with microneedling, to potentially enhance hair regrowth. The user plans to try BPC-157 due to its lower cost and reports of hair growth, despite limited human trials and concerns about side effects from other treatments like minoxidil and finasteride.

      community Dry flakes from topical fin use

      in Finasteride/Dutasteride  2 upvotes 1 year ago
      The user is experiencing white flakes and a greasy look from using a topical solution containing 0.025% finasteride, 8% minoxidil, 0.01% retinoic acid, and 1% hydrocortisone. Suggestions include reducing application frequency, using a brush to clean the scalp, and considering alcohol-free alternatives.