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GlossaryParkinson's disease (PD)

progressive neurodegenerative disorder affecting movement control due to dopamine loss

Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects movement control. It is characterized by symptoms such as tremors, stiffness, slowness of movement, and balance problems, resulting from the loss of dopamine-producing neurons in a region of the brain called the substantia nigra.

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community Finally Managed to Download Somebody's Alex pdf so try to share it

in Research/Science 70 upvotes 9 months ago

The conversation discusses a shared PDF about hair loss treatments, which might help those not seeing results with Minoxidil, Finasteride, and RU58841. Some users are skeptical about the content's value and the price charged for it.

community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

in Research/Science 13 upvotes 6 months ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

community NootBro Recommendations… How Do We Feel

in Research/Science 9 upvotes 5 months ago

The conversation is about hair loss treatments, specifically a stack including topical Ashwagandha, Copper Peptide, Gotu Kola, Ketoconazole, and PDA. One user found Topical and Sub-Q GHK-CU effective.

community Finasteride update/information on Penis/Penile Tissue

in Finasteride/Dutasteride 8 upvotes 1 year ago

Finasteride can reduce DHT in the genitalia, potentially causing side effects like reduced erections and penile fibrosis. Using PDE5 inhibitors like Tadalafil or Sildenafil may help maintain penile health and prevent fibrosis.

community Kintor announcement about pyrilutamide phase 3 results in CHINA

in Treatment 15 upvotes 11 months ago

Kintor announced Phase 3 results for pyrilutamide, a hair loss treatment, in China. The conversation is focused on this announcement and its implications for hair loss treatment.

community New (although questionable) paper: 5% topical spironolactone more effective than 0.1% topical finasteride

in Research/Science 8 upvotes 4 years ago

A questionable paper which suggests that 5% topical spironolactone is more effective than 0.1% topical finasteride for treating hair loss. It should be taken with a grain of salt due to the journal it was published in.

community Pyrilutamide phase III clinical trial results released

in Research/Science 31 upvotes 11 months ago

Pyrilutamide did not show effectiveness in regrowing hair compared to a placebo, but it may still help maintain existing hair by preventing DHT from causing follicle miniaturization. Some users believe it could be beneficial when used with other treatments like minoxidil, finasteride, and dutasteride.

community KX-826 Phase 3 Failed. Sorry guys...

in Research/Science 52 upvotes 11 months ago

The conversation discusses the failure of Phase 3 trials for the hair loss treatment KX-826, with no significant difference found between the drug and placebo. Some users express disappointment and skepticism, while others discuss alternative treatments like Minoxidil, finasteride, and RU58841.

community Pyrilutamide cleared for phase 3 clinical trial in china

in Research/Science 27 upvotes 2 years ago

Hair loss discussion includes Minoxidil, Finasteride, and RU58841 treatments. Pyrilutamide cleared for phase 3 clinical trial in China.

community Seriously confused about minoxidil's method of action

in Minoxidil 6 upvotes 2 years ago

The conversation discusses confusion about how Minoxidil promotes hair growth compared to other substances like Menthol, which have similar actions. The user mentions personal positive results with peppermint oil extract and is currently trying L-citrulline for its vasodilation effects.

community KX-826: Long-Term Safety Results are out!

in Research/Science 158 upvotes 1 month ago

KX-826 initially improves hair growth but declines after 24 weeks, with mild itching as a side effect. Combining it with minoxidil and finasteride may improve results, but long-term effectiveness is uncertain.

community [study analysis] Microdose of topical Finasteride for all the benefits and none of the sides?

in Research/Science 104 upvotes 4 years ago

Topical finasteride as a potential alternative to oral finasteride for reducing DHT levels on the scalp with fewer side effects, and other hair loss treatments such as minoxidil.

community Anti Fibrosis and Calcification regimen?

in Question 10 upvotes 6 years ago

The user experienced no improvement in hair loss with finasteride and minoxidil but had side effects. They plan to add wounding, scalp massage, vitamin K, and taurine supplements to their regimen and seek feedback on these additions.

community Is this VIOFAIRY Minoxidil brand good

in Minoxidil 2 upvotes 4 months ago

A user has been using a new brand of minoxidil called VIOFAIRY for six months and finds it effective, though the labeling has misspellings. They are seeking feedback from others who have tried this brand.

community How it’s going so far,I’ve been using fin and minox so far for a year this is the results

in Progress Pictures 36 upvotes 1 year ago

The conversation is about a person's experience with hair loss treatment using finasteride and minoxidil for a year, and then seeing improved results after adding RU58841. They suggest shaving the head before starting RU58841 to better track progress.

community minoxidil (15 months) and pyrilutamide (46 days) results.

in Is this regrowth? 20 upvotes 2 months ago

OP used minoxidil for 15 months and pyrilutamide for 46 days, achieving desired results without side effects. Users discussed alternatives like dutasteride and finasteride, with concerns about side effects like erectile dysfunction.

community TH07 - A New Novel Topical Treatment for Androgenic Alopecia

in Treatment 10 upvotes 4 months ago

Triple Hair Inc. developed a new topical treatment, TH07, combining Finasteride, Latanoprost, and Minoxidil for androgenic alopecia. Users discussed its effectiveness compared to other treatments and shared their own product combinations.

community Fagron TrichoTest says Finasteride won't help

in Treatment 13 upvotes 4 months ago

The user received a Fagron TrichoTest indicating that Finasteride, Dutasteride, and Minoxidil are not effective for them, recommending Latanoprost, Spironolactone, IGrantine-F1 TM, and Trichoxidil instead. Other users expressed skepticism about the test's validity and suggested sticking with proven treatments like Finasteride and Dutasteride.

community A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

in Research/Science 6 upvotes 5 months ago

Topical formulations, natural products, and CAM therapies are being used to treat Androgenic alopecia to avoid side effects of Finasteride and Minoxidil. The review covers various low-risk, alternative treatment options.

community Should Chairman Mao hop on Fin? 🤔

in Satire 191 upvotes 7 months ago

The conversation is a humorous discussion on whether the historical figure Chairman Mao should have used finasteride for hair loss, with various users making light-hearted comments about his appearance and historical actions. Specific treatments mentioned include finasteride.

community So what happened to the GT20029 phase 2 results?

in Chat 9 upvotes 7 months ago

The conversation is about the delay in the release of GT20029 phase 2 results by Kintor. It also mentions Minoxidil, finasteride, and RU58841 as treatments for hair loss.

community Q1 2024 is done. And kintor is completely silent about GT20029.

in Research/Science 32 upvotes 7 months ago

The conversation discusses the lack of updates on GT20029 for hair loss treatment, with some users noting recent reports indicating ongoing data collection. There are mentions of other treatments like Pyrilutamide and Minoxidil.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 123 upvotes 11 months ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community 2 years later I managed to gain some ground (Hyperresponder)

in Progress Pictures 43 upvotes 1 year ago

The user regained most of their hair using Minoxidil, Finasteride, and Dermarolling. They found Dermarolling particularly effective, as it promotes growth factors and improves hair thickness.

community 6 Month Progress Photos (2/2/23 - 8/19/23)

in Progress Pictures 50 upvotes 1 year ago

The post is about a user sharing their 6-month progress photos for hair loss. They have been using a homemade topical solution of minoxidil and finasteride, along with ketoconazole shampoo and microneedling. They are considering a hair transplant for their hairline and are seeking opinions on the graft amount.

community Optimal topical (leave in, not shampoo) caffeine concentration. Contradictions across studies.

in Research/Science 13 upvotes 1 year ago

One study suggests a 0.2% caffeine concentration is nearly as effective as 5% minoxidil for hair loss, while other findings indicate that concentrations between 0.001% and 0.005% are more effective, with 0.001% being the most effective. There is no clear consensus on the optimal caffeine concentration for hair loss treatment.

community M44 Hairloss Trichotest and Finasteride

in Finasteride/Dutasteride 6 upvotes 1 year ago

User received Trichotest results not recommending Finasteride. They are on Oral Minoxidil 2.50 and considering adding Finasteride.

community Platelet-rich plasma injection (PRP) question?

in Treatment 3 upvotes 1 year ago

Hair loss discussion includes PRP procedures. Some say it's not worth the money.

community if hmi-115 truly works, we can just get off off fin?

in Chat 19 upvotes 1 year ago

A potential new hair loss treatment, HMI-115, and the possibility of discontinuing finasteride in favor of it. The conversation also includes discussion about other benefits of using finasteride.

community Dutesteride time at which maximum serum DHT is supressed?

in Finasteride/Dutasteride 5 upvotes 1 year ago

Maximum serum DHT suppression for finasteride occurs at 8 hours, while for dutasteride, it occurs within 1 to 2 weeks with daily dosing. Dutasteride mesotherapy will be followed by blood tests to check serum DHT changes.