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PP405 trials have completed phase 2a, showing promising results with a 31% stat for hair density increase, and are moving directly to phase 3. Detailed results will be presented at a medical conference in 2026.

A female user is experiencing heavy hair shedding and receding temples, possibly due to low ferritin levels. She is using oral minoxidil, iron supplements, and ketoconazole shampoo, and is hesitant to start spironolactone.

The conversation is about using micro needling and PTD-DBM for hair loss treatment. The user applies PTD-DBM drops on weekdays and performs micro needling weekly.

OP mixed RU58841 with minoxidil and initially saw crystals, but realized they were bubbles. They asked for advice on application frequency for a 5% solution.

A user experimented with creatine while using finasteride and minoxidil for hair loss, noticing increased bald spots and thinner hair, but attributed it to his hair cycle rather than creatine. Other users suggested that creatine doesn't cause hair loss directly, but increased testosterone from workouts might affect those with a genetic predisposition.

Creatine use may increase hair shedding, with some users experiencing hair loss after a month of use, including a loading phase. Users are concerned about creatine's impact on hair despite using treatments like Minoxidil and finasteride.

Oral minoxidil and creatine can be used together, but it's advised to start one at a time to monitor side effects. Creatine may increase DHT levels, potentially causing more hair shedding, while minoxidil can lower blood pressure, so hydration and monitoring for dizziness are important.

Micronutrient testing and deficiencies related to hair loss, particularly androgenetic alopecia (AGA). Discussion includes the impact of iron, selenium, zinc, copper, folate, B12, vitamin E, vitamin D, amino acids, and fatty acids, alongside treatments like dutasteride or finasteride.

A natural sugar called 2dDR may stimulate hair growth and is comparable to minoxidil, but it's not widely available for purchase. Concerns about minoxidil's safety for pets were discussed, with some users seeking alternatives.

A user experienced hair loss in a transplanted area after using creatine for four months, despite being on finasteride for three years. They stopped creatine, hoping the hair loss is temporary shedding rather than permanent.

RU58841's side effects may be exaggerated due to anxiety, with some users experiencing no issues and others reporting symptoms like chest pain. RU58841, minoxidil, and finasteride are used for hair loss treatment, with varying individual reactions.

RU58841 pre-mixed solution loses effectiveness after two weeks. Users suggest mixing RU58841 powder with ethanol and PG instead of Minoxidil for better results.

Minoxidil is highly toxic to cats, and even small amounts can be fatal. The user decided against using topical minoxidil due to the risk to their cats and considered oral minoxidil and ketoconazole shampoo as alternatives.

Glycosaminoglycans are important for hair growth, and combining minoxidil with tretinoin and Biopeptide-CL may enhance hair growth by boosting glycosaminoglycan levels and improving the hair follicle environment. Users discussed the potential effectiveness and future of these treatments.

A user asked if they can crush caffeine and melatonin tablets to add to their minoxidil solution. Another user sarcastically suggested adding rat poison.

Creatine's link to hair loss is debated, with some users reporting increased hair loss and others seeing no effect. Treatments like finasteride and minoxidil are used by some to manage hair loss.

Creatine use with finasteride increased DHT levels, possibly affecting hair loss. The user plans to reduce creatine to stabilize DHT and hair shedding.

The user experienced a decrease in DHT levels after starting finasteride and noted improved gym performance with creatine. They observed hair improvement and are considering adding more minoxidil to their routine.

Stopping creatine may reduce hair shedding within a month. Users suggest avoiding creatine if concerned about hair loss.

Oral minoxidil is generally effective for hair loss but may cause side effects like heart palpitations and facial puffiness. Users highlight the importance of monitoring blood pressure due to potential cardiovascular risks.

The user experienced significant hair regrowth and improved appearance using dutasteride, with no side effects, and is concerned about whether gym workouts and creatine might affect these gains. They previously used minoxidil but disliked its effects and stopped due to its inconvenience.

RU58841 and Minoxidil can cause heart-related side effects like chest pain and heart racing. Pyrilutamide is suggested as a safer alternative, though it's new and costly.

A user shared 3 months of hair loss progress using topical minoxidil 5%, biotin, and increased protein. The user noted steady improvement and the benefit of progress pictures.

Whey protein does not cause hair loss; concerns are likely unfounded. The user is on finasteride and minoxidil but sees no improvement, so they are phasing out these treatments while continuing to work out and use whey protein.

Broccoli or sulforaphane supplements are unlikely to improve Minoxidil results due to the need for an unrealistically large dose. Tretinoin, micro-needling, and low-dose oral Minoxidil may be more effective for those lacking the necessary enzyme in the scalp.

Creatine may increase DHT levels, potentially accelerating hair loss in those predisposed. Some users suggest using finasteride or dutasteride to counteract this effect.

KX-826 Phase II results show that a 0.5% concentration performs better than 1% for treating male pattern baldness. Concerns about receptor upregulation from long-term DHT antagonism were mentioned.

The user experienced significant hair regrowth after switching from fake to genuine minoxidil, alongside continued use of finasteride. They advise caution when purchasing minoxidil from Amazon due to the risk of counterfeit products.

Formula 82M, a minoxidil and retinol liquid, improved hair texture and filled in temples with baby hairs for the user, but its high cost and lack of reviews cause concern. Another user mentioned using a similar product, 82F, which has become less effective and expensive over time.

Oral minoxidil can still work without the SULT1A1 enzyme because the liver has enough of it, but its effectiveness on the scalp depends on transporters. Oral minoxidil generally does not affect blood pressure at low doses.