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Pelage Pharmaceuticals is starting Phase 3 trials for PP405 in September 2026, with potential market release by 2030. Users discuss various hair loss treatments like minoxidil, finasteride, RU58841, kx, breezula, and gt20029, expressing hope for future hair restoration.

The user has been using minoxidil and finasteride for a year with continued hair thinning and is considering a hair transplant for diffuse thinning. Suggestions include addressing scalp inflammation and possibly trying dutasteride or switching to oral minoxidil.

Hair loss treatments like finasteride, minoxidil, and dutasteride are discussed, with some users expressing skepticism about finding a permanent cure. Current treatments are considered effective but not a permanent solution, and there's a call for advanced AI to focus on solving male pattern baldness.

The user experienced worsening hair loss after 8 months of using finasteride and minoxidil, with no initial shedding or improvement. Suggestions included checking for autoimmune issues, thyroid problems, and consulting a dermatologist.

The user has been using finasteride and oral minoxidil for two years without improvement in diffuse thinning and is considering switching to dutasteride and getting a scalp biopsy. Suggestions include treating subclinical hypothyroidism, trying PRP therapy, and checking for autoimmune issues.

An arthritis drug, Rinvoq, restores hair in some alopecia areata patients but is not effective for androgenetic alopecia. It is used for autoimmune-related skin disorders, but its high cost and lack of insurance coverage are issues.

An arthritis drug restored significant hair in people with alopecia areata, but it is not effective for male pattern baldness. The drug, Upadacitinib, has serious side effects and is expensive.

A user is asking if Dutasteride can be effective when Finasteride has not stopped hair follicle miniaturization, despite having non-aggressive hair loss. The user has been using Finasteride for 2.5 years without success.

A 38-year-old is concerned about hair loss despite having a good hairline and has been using topical finasteride and minoxidil for a year, considering switching to oral treatments. Suggestions include continuing the current regimen, trying microneedling, or switching to oral finasteride.

RU58841 is considered ineffective as a standalone treatment for hair loss, with users often combining it with finasteride and minoxidil for potential benefits. Many users report mixed results and concerns about side effects, leading to skepticism about its efficacy.

Scalp pain alongside hair loss may indicate inflammation rather than just male pattern baldness. Treatments mentioned include triamcinolone acetonide, fluocinonide, Head & Shoulders shampoo, aloe vera gel, finasteride, and 2% Nizoral.

Dutasteride is seen as a more effective treatment for hair loss compared to finasteride and minoxidil, with users noticing reduced hair fall and thicker hair within weeks. Many users report taking 0.5 mg of Dutasteride daily, sometimes alongside finasteride, and suggest transitioning gradually to avoid shedding.

The user experienced hair loss after switching from topical to oral minoxidil and adding dutasteride, leading to doubts about its effectiveness. They are considering returning to RU58841 or topical minoxidil due to continued shedding and mental distress.

Hair transplants are not permanent and require medication like finasteride or dutasteride to maintain results, as transplanted hair can still thin over time. Individuals with a history of prostate cancer may need to avoid these medications due to potential health risks.

The conversation is about a user taking 0.25mg finasteride every other day for hair loss, experiencing shedding but no side effects, and seeking reassurance. Users suggest increasing the dosage, adding minoxidil, or considering dutasteride for better results.

The user has been taking finasteride for 3 months and is experiencing hair shedding, hoping for improvement by month 6 or 7. Another user suggests that hair thickening can occur by month 7, based on personal experience.

The conversation discusses a user's worsening scalp condition, possibly seborrheic dermatitis, despite using keto shampoo. Suggestions include using MCT C8 oil, adjusting diet by reducing carbs and sugars, and consulting a dermatologist.

A user is experiencing hair thinning despite using finasteride and dutasteride and is considering adding oral minoxidil for potential regrowth. Others suggest combining treatments like oral dutasteride with topical minoxidil and emphasize patience for results.

Breezula is seen as a potential future treatment for hair loss, but its release is uncertain and current data is limited. Other treatments like GT20026 and pyrilutamide are discussed, but skepticism remains about their effectiveness compared to established options like finasteride and minoxidil.

A 23-year-old shares progress using oral minoxidil and finasteride for hair regrowth, reporting significant improvement in hair density with minimal side effects like initial headaches. The user encourages others with thinning hair to consider these treatments, noting the positive impact on confidence.

The user shared progress pictures after using Finasteride, RU58841, and Minoxidil for 5 months, reporting no side effects and planning to switch to Dutasteride and oral Minoxidil. They noted that Finasteride and RU58841 helped regrow natural hair, while the transplanted hair remained unchanged.

Minoxidil has maintained hair stability for a decade, but users suggest combining it with other treatments like finasteride or microneedling for better results. Some believe minoxidil alone is insufficient for long-term hair loss prevention.

Low ferritin can contribute to hair loss despite normal iron levels, and supplementing iron may help improve hair regrowth when using finasteride. Minoxidil might also aid in recovery, and optimal ferritin levels for hair growth are suggested to be 100+ ng/ml.

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

The conversation humorously suggests accepting male pattern baldness by adopting historical hairstyles like those of the Manchus and Japanese, rather than hoping for a cure. It also discusses the potential of gene therapy targeting hair loss, despite skepticism about a definitive cure.

The conversation discusses hair loss treatments, focusing on insulin resistance, microneedling with topical melatonin, and stress reduction. Users express skepticism about the advice, preferring proven treatments like minoxidil and finasteride, while some mention alternative methods like dermal incisions and verteporfin for reducing fibrosis.

PP405 updates are seen as vague and lacking substance, causing frustration among users. Some users report positive effects from using minoxidil and dutasteride, while others remain skeptical about new treatments.

A user is curious why their DHT levels are not higher despite using 400mg of testosterone without finasteride, and wonders if zinc or GHK-Cu injections could be influencing this. Another user suggests that more testosterone typically leads to more DHT, but the user might be fortunate not to exceed normal DHT levels.

The user is using finasteride, HGH, GHK-CU, BPC-157, KPV, biotin/collagen/keratin vitamins, ketoconazole shampoo, and low-dose naltrexone to address hair loss, avoiding minoxidil due to past shedding experiences. Adenosine is discussed as a potential alternative to minoxidil, though it is noted to be expensive and hard to find.

The user is experiencing hair that doesn't grow past a certain length despite using minoxidil and finasteride for male pattern baldness. Suggestions include trying dutasteride, microneedles, and ketoconazole shampoo.