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      community Binding affinity of pyrilutamide!

      in Update  171 upvotes 2 years ago
      Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

      community Black Hair Regrowth Process Timeline

      in Progress Pictures  70 upvotes 2 years ago
      Treating Black/ethnic hair loss with a combination of Minoxidil, finasteride, Nizoral shampoo and derma pen treatments, as well as occasional Jamaican Black Caster Oil use. The user documented their progress over the course of 3.5 months, showing improvement in hair growth.

      community Trying to understand finasteride side effects and post finasteride syndrome

      in Finasteride/Dutasteride  74 upvotes 4 years ago
      The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

      community If you’re sitting there wondering, “I’m losing my hair, what do I do?” then read my advice here. I’ve been fighting the fight for 7 years, with great success. (pictures included)

      in Question  106 upvotes 11 years ago
      Fighting hair loss with "The Big 3" treatments of Propecia, Rogaine and Nizoral shampoo, as well as specific advice on how to use these products. People have shared their long-term success stories and some have discussed the side effects of finasteride. Other suggestions included Lipogaine and Pura D'or Hair Loss Prevention Therapy Shampoo & Conditioner.

      community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

      in Progress Pictures  224 upvotes 7 months ago
      A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

      community 2Y 5M on dut, ask me anything

      in Finasteride/Dutasteride  125 upvotes 2 weeks ago
      A user experienced significant hair regrowth using dutasteride without side effects, starting with finasteride and not using minoxidil or dermarolling. They attributed success to a unique genetic response to DHT blockers but did not share their full regimen, frustrating others.

      community What else is good. Besides the big 3.

      in Chat  37 upvotes 3 weeks ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 2 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Haircafe on why microneedling is bad for hair growth

      in Microneedling  151 upvotes 2 months ago
      Microneedling combined with minoxidil and finasteride shows significant hair regrowth, though opinions on its effectiveness vary. Some users report substantial benefits, while others highlight the need for more research and consistency in application.

      community Proof that finasteride messes with neurosteroids

      in Research/Science  230 upvotes 3 months ago
      Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

      community Topical finasteride now the safest possible path?

      in Finasteride/Dutasteride  50 upvotes 3 months ago
      Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

      community Just popped my first fin, excited as hell!

      in Finasteride/Dutasteride  154 upvotes 5 months ago
      A user shared their excitement about starting finasteride for hair loss after trying various ineffective methods. Other users discussed their experiences with finasteride, including shedding phases and side effects, with one mentioning using topical finasteride and minoxidil.

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 7 months ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

      community People here just don't know what they are letting themselves in for!

      in Chat  123 upvotes 7 months ago
      The conversation discusses hair loss treatments, emphasizing the importance of patience and sticking with a treatment for at least 12-18 months before judging its effectiveness or adding new treatments. Users share experiences and agree that introducing treatments too quickly can lead to panic and negative outcomes.

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 7 months ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

      community 2 Year Fin/Min/Niz Journey AMA

      in Progress Pictures  1193 upvotes 9 months ago
      A user shared their 2-year hair loss treatment journey using 1mg finasteride daily, 2ml minoxidil daily, Nizoral shampoo 2-3 times a week, recently added dutasteride twice a week, and microneedling once a week. They've seen improvement in their hair and advise consistency with medication, with some users responding positively to the progress.

      community Is this true? Is long term taking fin harmful to the liver?

      in Chat  127 upvotes 9 months ago
      The conversation discusses whether long-term use of finasteride (Fin) is harmful to the liver, with various opinions on side effects and comparisons to other substances. Specific treatments mentioned include finasteride, minoxidil (Min), and RU58841 (RU).

      community Huberman tweet about finasteride

      in Finasteride/Dutasteride  278 upvotes 11 months ago
      The conversation is about the side effects of finasteride, including Post Finasteride Syndrome, with varied personal experiences and differing views on the credibility of information sources. Some participants also discuss using minoxidil as a hair loss treatment.

      community Andrew Schulz stated he had been using a ‘’hair pill’’ for 15 years and it may have caused him infertility

      in Satire  134 upvotes 11 months ago
      The conversation discusses the potential link between hair loss treatment pills, specifically finasteride, and infertility. Users share their experiences and opinions, with some suggesting that finasteride can temporarily lower sperm count, while others argue that other factors like age and lifestyle could also contribute to infertility.

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 1 year ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community What’s your nuclear protocol???

      in Chat  21 upvotes 1 year ago
      People discussed their intense hair loss treatments, including the use of dutasteride, RU58841, minoxidil, tretinoin, essential oils, microneedling, and various topical sprays. Some users reported success with these methods in preventing hair loss and stimulating hair growth.