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The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

Finasteride may cause elevated liver enzymes, potentially leading to liver issues, though this is rare. Users should monitor liver function and consider topical alternatives if liver sensitivity occurs.

A user is considering a long-term hair loss treatment stack including Dutasteride, Finasteride, and oral Minoxidil, and is concerned about potential liver damage. Some responses suggest the stack is excessive, while others believe it's not harmful to the liver, but recommend regular blood work to monitor health.

A user shared their experience with high cholesterol, glucose, and potential metabolic syndrome after using Finasteride and Dutasteride for hair loss. They plan to improve their health with diet and exercise before considering medication.

Dutasteride users should get yearly kidney and liver tests, especially young people. General health checkups are not common in the UK, but such tests are recommended as a precaution.

Long-term use of finasteride and dutasteride may be linked to health risks like fatty liver disease, insulin resistance, type 2 diabetes, dry eye disease, and potential kidney disease. Some users believe the risks are low and the medications are generally safe.

The conversation discusses whether long-term use of finasteride (Fin) is harmful to the liver, with various opinions on side effects and comparisons to other substances. Specific treatments mentioned include finasteride, minoxidil (Min), and RU58841 (RU).

Finasteride may affect liver function and cortisol levels, potentially linking it to non-alcoholic fatty liver disease (NAFLD). More research is needed to understand this connection fully.

Finasteride is metabolized in the liver and excreted through urine and feces. Users humorously discuss its excretion, with one joking about it being expelled through ejaculation.

User experienced severe allergic reactions and liver issues after a hair transplant, likely due to antibiotics and medications. Despite trying Minoxidil, the user faced further complications and is now seeking medical advice for potential future transplants.

Dutasteride can lead to increased cholesterol and liver fat. The user is reconsidering its use due to high cholesterol and lipid levels despite a healthy lifestyle.

The user experienced significant hair regrowth using topical Minoxidil and Finasteride but had to stop due to high liver enzyme levels. They plan to pause treatment for a month to see if their liver values return to normal.

Salicylic Acid shampoo may hinder topical minoxidil but not oral minoxidil, which works through the liver. The user plans to continue using oral minoxidil and is concerned about the shampoo's effect on it.

People discussed vitamin D deficiency and its link to hair loss. One user added cod liver oil to their regimen to boost vitamin D.

Topical liquid minoxidil may be safe to consume in small amounts, but it needs liver processing to become effective for hair growth. Therefore, oral pills might be more effective.

The post and conversation are about the long-term side effects of using Dutasteride and Finasteride for hair loss, including issues like raised liver enzymes, high cholesterol, and loss of libido. The user advises regular blood work and careful monitoring for those using these treatments.

The potential risks of long-term use of Dutasteride and how it may be linked to elevated liver enzymes, cholesterol levels, and decreased testosterone. Alternative treatments such as Finasteride and RU58841 were also discussed.

Dutasteride and finasteride can affect libido differently, with some experiencing increased libido and others decreased libido or erectile dysfunction. Dutasteride may increase testosterone levels but can also cause side effects like liver enzyme changes, while topical finasteride may have fewer sexual side effects.

A user in the UK seeks advice on blood tests before starting Finasteride and Minoxidil for hair loss. Recommended tests include thyroid function, hormone levels, liver and kidney function, and vitamin and mineral levels.

A user started taking 2.5mg Dutasteride for hair loss, along with oral Minoxidil, and is concerned about liver impact. Other users warn about the high dosage and potential health risks.

A user noticed non-itchy, non-bleeding spots on their scalp while experiencing hair loss. Replies suggest the spots are likely sunspots or liver spots and recommend seeing a dermatologist; hair loss is attributed to male pattern baldness.

The user experienced severe hair shedding despite using oral finasteride, minoxidil, dutasteride, and RU58841, and was diagnosed with Non-Alcoholic Fatty Liver Disease (NAFLD). They are considering switching to topical treatments due to the ineffectiveness of their current regimen.

The user switched from oral finasteride to dutasteride with minoxidil, but saw no results. They then tried topical finasteride and noticed some potential improvement after four months, theorizing that the topical application bypasses liver metabolism.

The conversation discusses the potential benefits of sublingual minoxidil for hair loss treatment. It suggests that sublingual minoxidil, which bypasses the liver, may have fewer side effects, greater bioavailability, and could be more effective than oral minoxidil.

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

Dutasteride is associated with increased blood glucose, HbA1c, LDL cholesterol, and liver enzyme activity, potentially leading to diabetes, NAFLD, and liver metabolism changes. The conversation highlights concerns about these adverse effects and calls for more studies, including on finasteride.

Following a Ray Peat diet led to less hair fall, thicker hair, and new hair growth at bald spots. The diet included stopping Omega 3 supplements, eating liver, increasing fruit, sugar, and saturated fat intake, and occasionally consuming coffee, tea, raw carrots, and shellfish.

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

A user shared an 8-month hair regrowth progress using finasteride, topical minoxidil, and microneedling, and others reacted positively, asking for details about the treatment regimen. The user also mentioned taking cod liver oil and a hair multivitamin with biotin and collagen.

The post discusses a holistic, bioenergetic approach to hair loss, focusing on diet, exercise, and lifestyle changes rather than traditional treatments like finasteride or minoxidil. Key dietary recommendations include fruits, milk, potatoes, butter, coconut oil, eggs, oysters, liver, and gelatin, along with moderate exercise and lifestyle adjustments to reduce stress.