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GlossaryIsotretinoin (Isotrex)

oral medication for severe acne unresponsive to other treatments

Isotretinoin, also known by brand names like Accutane, is a powerful oral medication primarily used to treat severe acne that hasn't responded to other treatments. It works by reducing the amount of oil released by oil glands in your skin, helping your skin renew itself more quickly. While highly effective, it can have significant side effects and is typically prescribed under strict medical supervision.

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community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 1 year ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community Oral min and Isotretinoin (accutane) to respond

in Chat 2 months ago

Oral minoxidil combined with isotretinoin may improve hair loss treatment effectiveness. Tretinoin is known to increase the absorption of topical minoxidil.

community Which retinoid for better min absorption?

in Product 4 upvotes 2 months ago

User is on vacation in Greece and wants to buy tretinoin or isotretinoin to improve Minoxidil absorption. They are considering isotretinoin since it is available over-the-counter in Greece but requires a prescription back home.

community Dut/Minox/Needling to Dut/Oral Minox/Tretinoin/Needling

in Minoxidil 3 upvotes 5 months ago

The user had been using Minoxidil and Dutasteride with micro-needling but experienced hair loss after switching Minoxidil brands. Their doctor prescribed oral Minoxidil and Tretinoin, but the pharmacist suggested isotretinoin might be a more cost-effective alternative.

community Seborrheic dermatitis - can it cause long-term shedding (or telogen effluvium)?

in Advice 6 upvotes 4 years ago

A user is experiencing significant hair loss and scalp issues despite using Minoxidil, finasteride, and RU58841 since 2017. They switched to oral Minoxidil and are now on isotretinoin and topical corticosteroids for seborrheic dermatitis but continue to lose hair and seek advice on whether inflammation or treatment changes are the cause.

community Correlation between topical retinoids and diffuse hair loss

in Research/Science 7 upvotes 2 years ago

Excess Vitamin A and topical retinoids can cause diffuse hair shedding. The user suspects their chronic telogen effluvium may be linked to using adapalene, a topical retinoid.

community What’s the consensus on tretinoin?

in Treatment 7 upvotes 4 months ago

Tretinoin may increase minoxidil absorption but could potentially worsen hair loss over time. Users discuss applying 0.5% tretinoin gel to the hairline/scalp with minoxidil.

community I'm 20 y.o. and losing hairs. Could you help me somehow?

in Chat 9 upvotes 3 years ago

A 20-year-old is experiencing hair loss and has tried Minoxidil, ketoconazole shampoo, dermarolling, Biotin, Selenium, Zinc, and a shampoo with various ingredients but is still losing hair. They had side effects from topical finasteride and are considering RU58841 but are concerned about past heart issues.

community Female diffuse hair loss on spiro with irregular periods (photos) + genetic hair loss

in Female 17 upvotes 1 month ago

A 34-year-old woman is experiencing diffuse hair loss and irregular periods, possibly due to long-term spironolactone use. She is considering minoxidil and finasteride for treatment and seeking medical advice for androgenic alopecia and hormonal imbalances.

community How to manage a routine with minox + tret + microneedling

in Treatment 1 upvotes 4 months ago

The conversation is about managing a hair loss routine using Minoxidil twice daily, Tretinoin cream once daily at night, and microneedling once daily at night. The user is seeking advice on how to incorporate these treatments effectively without overlapping too much at night.

community 1 year on Finasteride, 2 months on derma rolling and minoxidil

in Progress Pictures 75 upvotes 11 months ago

The user has been on Finasteride for over a year and recently added minoxidil and derma rolling to their regimen, experiencing side effects like headaches and acne for a few weeks. They tried various non-medication treatments for early-stage hair loss with no success before turning to medication, which improved their hair and confidence.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 62 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community 5 weeks of Minoxidil. Early results of regrowth? 😬

in Is this regrowth? 133 upvotes 1 year ago

The user is seeking feedback on their hair regrowth progress after using Minoxidil for 5 weeks, along with other treatments. Some users share their experiences, mentioning that Minoxidil may not provide a permanent solution and that results vary. It is advised to take before pictures for better assessment.

community New hack? Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes

in Research/Science 15 upvotes 1 year ago

The conversation discusses how Tretinoin may improve the effectiveness of Minoxidil for treating hair loss by increasing the activity of certain enzymes in hair follicles. One user comments that this information is not new.

community So excited! Just got dutasteride for free when I forever thought I’d have to pay! 😭

in Finasteride/Dutasteride 30 upvotes 2 years ago

A user who was able to get dutasteride for free with their insurance, and another user mentioning that finasteride is only covered if it is used for medical reasons.

community Oral minoxidil can causes age skin?

in Minoxidil 8 upvotes 2 years ago

Oral minoxidil may cause skin aging, such as dark circles. To counteract aging, use tretinoin at night and broad-spectrum sunscreen during the day.

community I got ripped off by a hair clinic last year and feel so dumb

in Treatment 34 upvotes 2 years ago

A user's experience with an expensive hair loss clinic that failed to produce the desired results, and advice from other users on treatments such as Minoxidil, Finasteride, and RU58841.

community Massive preliminary success with my thorough regime

in Update 4 upvotes 3 years ago

A 28-year-old male reported significant hair regrowth after 5 weeks using a regime including Minoxidil, Ketozolin shampoo, microneedling, hyaluronic acid, saw palmetto, pumpkin seed, MSM, frankincense, zinc, multivitamins, and vitamin D. He also noted improvements in digestion, dry eyes, and skin health, and observed beard growth from microneedling.

community What else is good. Besides the big 3.

in Chat 37 upvotes 3 weeks ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 2 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Haircafe on why microneedling is bad for hair growth

in Microneedling 151 upvotes 2 months ago

Microneedling combined with minoxidil and finasteride shows significant hair regrowth, though opinions on its effectiveness vary. Some users report substantial benefits, while others highlight the need for more research and consistency in application.

community Tretinoin, any good, what’s your experience

in Research/Science 21 upvotes 5 months ago

The conversation discusses using tretinoin for hair loss and skincare. Users share experiences, noting tretinoin's effectiveness in combination with minoxidil for hair and its proven benefits for anti-aging skincare.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 6 months ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

community Started Finasteride almost three months ago and I'm upset

in Update 153 upvotes 7 months ago

A user started taking finasteride three months ago to treat hair loss and unexpectedly cleared their acne, which they had been struggling with since age 12. The conversation includes others sharing their experiences with finasteride, its effects on acne and hair loss, and mentions a related treatment, clascoterone, for acne and hair loss.

community I’m really tired of using minoxidil

in Minoxidil 42 upvotes 10 months ago

The user is frustrated with minoxidil's lack of results and is considering alternatives like oral minoxidil or finasteride despite concerns about side effects. Other suggestions include consulting a doctor, adjusting dosages, or considering a hair transplant.

community Nine Month Progress: Bless The Person Who Developed Finasteride And Minoxidil (20M)

in Progress Pictures 592 upvotes 11 months ago

A user shared a nine-month hair regrowth progress using 5mg oral Minoxidil and 1.25mg oral Finasteride daily, with noticeable improvement and no side effects, despite a high-protein diet, occasional smoking, and regular exercise. They also mentioned using keto shampoo and having naturally increased body hair by about 10%.

community Why is no one pointing out dandruff as the number 1 evidence/symptom of MPB?

in Chat 55 upvotes 1 year ago

The post discusses the theory that persistent dandruff in areas prone to hair loss could be a sign of hair follicles dying due to DHT, indicating balding. The responses vary, with some users noting improvements in dandruff and hair loss with treatments like Dutasteride, while others experienced hair loss without dandruff.

community 22M Fin and min everyday for 10 months, looks like my right temple is still receding

in Finasteride/Dutasteride 67 upvotes 1 year ago

The user is seeking opinions on their hair loss, specifically the receding of their right temple. They are considering switching to Dutasteride but are unsure if it will help. Other users suggest that their hairline has improved with the use of Finasteride and Minoxidil. One user mentions using RU58841 to thicken their hairline.

community Anyone else’s beard took a huge hit on finasteride or dutasteride? Would minoxidl hepl?

in Progress Pictures 105 upvotes 1 year ago

The effects of finasteride and dutasteride on beard growth, whether minoxidil would help with facial hair loss caused by DHT blockers, and anecdotal evidence from users who have experienced either decreased or increased facial hair density while using these treatments.

community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

in Progress Pictures 83 upvotes 1 year ago

Treating Seborrheic Dermatitis, a fungal scalp condition which can cause hair loss. Treatments discussed include antifungal shampoos, cold showers, exfoliating the scalp, taking Vitamin D, and stimulating the prostate through the anus.