PP405, a topical LDH inhibitor, has shown to stimulate hair follicle stem cell proliferation in humans with moderate hairloss. They are advancing to more detailed trials this year.
The conversation concludes that finasteride, a 5α-Reductase inhibitor used for hairloss, does not impair cognition either short-term or long-term. It suggests "brain fog" is not caused by the medication.
The conversation discusses whether age affects the side effects and effectiveness of hairloss treatments like finasteride and dutasteride. Some believe early treatment yields better results, while others mention varied outcomes across ages and personal regrowth experiences without a clear consensus on age impact.
The conversation is about whether it is safe to take Xeljanz, a JAK inhibitor, while also taking finasteride for hairloss. The concern is that Xeljanz weakens the immune system, which could be risky.
The conversation is about which blood markers to test before starting a 5-AR inhibitor for hairloss. The user mentions already testing Total T, Free T, SHBG, Estradiol, Haematocrit, Red blood cell count, and White cell count, and asks if DHT or additional markers are needed.
The post is a humorous take on the author's experience with hairloss and using finasteride for six months. The conversation includes discussions about hairloss, treatments like finasteride, and personal experiences with baldness.
Finasteride and dutasteride, used for hairloss, can cause sexual dysfunction, depression, and suicidal thoughts, with some effects persisting after stopping. The post stresses the importance of being aware of these risks.
User uses dermaroller and minox for hairloss without success, considers adding Stemoxydine and mixing tretinoin with minox. Another user suggests a DHT inhibitor for sustainability.
Dutasteride is likely the most effective treatment for male pattern baldness, followed by finasteride and minoxidil in various forms and dosages. Users discuss personal experiences, dosages, and potential side effects, with some considering combining treatments for better results.
Hairloss discussion includes finasteride intolerance and questioning if Pyrilutamide is an alternative. Pyrilutamide not commercially available, but may be tolerable if approved since it's not a 5aR inhibitor.
The conversation discusses the potential use of verteporfin for hairloss treatment, with one user mentioning their surgeon's interest in trying it and another noting its research status and clinical use as a YAP inhibitor. Some users debate the market size, availability of generics, and the optimism in the hairloss community regarding new treatments.
Hairloss treatments, ranging from topical minoxidil and finasteride to taking hormones such as estradiol or nandrolone, as well as a controversial suggestion of an orchiectomy. A hair system is also mentioned as an alternative solution.
The conclusion of the conversation is that the user should consider using treatments such as finasteride, minoxidil, and RU58841 to potentially reverse their hairloss. Other suggestions include using hairloss concealers and maintaining a healthy diet.
The conversation is about hairloss treatments, specifically the anticipation for the release of a new treatment, GT20029, by 2028. Users are discussing their experiences with current treatments like finasteride and dutasteride, and the potential of future treatments, including FAK inhibitors and verteporfin trials.
Scalp biopsies are crucial for diagnosing hairloss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hairloss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.
The conversation discusses various hairloss treatments, highlighting Advanced Trichology Topical Melatonin Hair Growth Serum, hers Minoxidil Foam, Keranique Hair Regrowth Treatment, Nioxin 5% Minoxidil, Virtue Minoxidil 5%, and Rogaine Women's 2% Minoxidil. One user suggests that the list may be influenced by sponsorship and emphasizes that minoxidil is commonly recommended but doesn't address the root cause of hairloss like finasteride or dutasteride.
GT20029, a new hairloss treatment, shows promising results but only a slight improvement over placebo. People are cautiously optimistic, discussing its potential and combining it with existing treatments like Minoxidil and Finasteride.
A 30-year-old woman with controlled hair thinning stopped taking Spironolactone due to side effects and is considering Dutasteride. She seeks feedback from other women who have used Dutasteride for hairloss.
The conversation is about the role of testosterone in hairloss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hairloss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hairloss.
Isotretinoin may cause hairloss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hairloss.
Dutasteride Mesotherapy for hairloss is discussed, noting its potential to lower scalp DHT without side effects. Concerns include the inconvenience of injections, lack of reputable studies, and availability issues.
A 25-year-old male experiencing hairloss and thinning since age 20 is seeking advice on effective DHT inhibitors. He lists various oral and topical treatments, excluding Minoxidil due to adverse effects.
The post discusses a hairloss treatment regimen using saw palmetto, pumpkin seed oil extract, EGCG (green tea) extract, grape seed oil extract, rosemary oil extract, and Zix. The user plans to use these DHT-blockers and 5AR inhibitors for six months and report the results.
A 20-year-old user experienced worsening hairloss despite using various treatments including topical and oral minoxidil, finasteride, and dutasteride. Other users suggested additional treatments like JAK inhibitors, RU58841, and lifestyle changes, but the user remains skeptical and frustrated.
Heavy nicotine use can lead to hair thinning and loss, but quitting can reverse these effects. The user noticed significant hair regrowth after quitting vaping.
The user is using finasteride, dutasteride, Nizoral, biotin, RU58841, minoxidil, Pantostin/Alfatradiol, Stemoxydine, and micro needling for hairloss. They are considering adding oral minoxidil.
A 24-year-old man is seeking advice on his current hairloss treatment, which includes 0.5mg Dutasteride daily, 2.5 mg oral Minoxidil daily, and daily low-level light laser therapy, as he's not seen improvement recently. He's also considering a hair transplant in South Korea at age 25 and is asking for opinions on this plan.
A 19-year-old with rapid hairloss since 16 is considering a hair transplant but refuses to take finasteride or any 5α-Reductase inhibitors. They are currently using minoxidil, tretinoin, and microneedling with a Derminator 2, and only want hair until age 27.
Researching and developing an effective local antagonist to block the androgen receptors for hairloss, as opposed to using DHT synthesis inhibitors that lower serum DHT levels. Several treatments such as CosmeRNA and Pyrilutamide are currently in development or undergoing trials.