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      community Anyone ever get a shedding phase on RU58441

      in Chat  6 upvotes 2 months ago
      The user experienced increased hair shedding after using RU58841 for two months, but found relief from scalp itchiness. Other users shared similar shedding experiences and discussed side effects like joint pain, while also mentioning the use of finasteride and minoxidil.

      community Is Pyri worth it at the moment?

      in Chat  26 upvotes 1 year ago
      The conversation is about the effectiveness and safety of a hair loss treatment called Pyri, with users discussing its availability and comparing it to other treatments like RU58841, fluridil, and alfatradiol. Some users are waiting for FDA approval before using Pyri, while others share their positive experiences with RU58841 and suggest additional treatments with minimal side effects.

      community Don’t make the same mistake I did

      in Treatment  111 upvotes 2 years ago
      User noticed hair thinning at 26 and used minoxidil for 2 years with slight improvement. Stopping minoxidil led to dramatic hair loss, and others shared similar experiences, suggesting minoxidil and finasteride should be used consistently for best results.

      community Mix Pyrilutamide powder in Minoxidil solution?

      in Minoxidil  3 upvotes 1 year ago
      Mixing Pyrilutamide powder with Minoxidil solution is being considered. The Minoxidil solution contains Minoxidil 5%, Azelaic acid 5%, ABN complex 0.8%, Retinol 0.025%, Caffeine 0.001%, and a delivery vehicle.

      community Ru-58841 or KX-826 (Pyrilutamide)?

      in Treatment  12 upvotes 1 year ago
      Exploring potential treatments for hair loss, with the focus being on comparing RU58841 and Pyrilutamide. Finasteride, Dutasteride, oral Minoxidil, microneedling, topical Minoxidil, Biotin, Zinc, Vitamin D and Nizoral are also discussed as part of a treatment stack.

      community Binding affinity of pyrilutamide!

      in Update  167 upvotes 2 years ago
      Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

      community Where the fuck are the pyrilutamide GB guys?

      in Chat  23 upvotes 2 years ago
      The effects of Pyrilutamide, a hair loss treatment that is being tested for June/July; and reports from people who have experienced side effects similar to those of RU58841, suggesting they may have been sold an incorrect product from their supplier.

      community My personal experience/observations fighting AGA seriously for 5 years

      in Treatment  43 upvotes 2 weeks ago
      Minoxidil with alcohol and propylene glycol was more effective than non-alcohol versions, and RU58841 worked best in a non-water-based solution. Oral finasteride showed better results than topical, despite side effects; microneedling and tretinoin worsened hair loss, and PRP was only helpful when younger.
      The story of RU58841/ PSK3841

      community The story of RU58841/ PSK3841

      in Research  622 upvotes 4 months ago
      RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

      community TDM-105795 phase 2 results are in!

      in Research/Science  28 upvotes 10 months ago
      TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

      community RU58841 vehicle penetration (Study for minoxidil)

      in Treatment  12 upvotes 1 year ago
      The user mixes their own RU58841 solution and found that increasing the ethanol content improved absorption and reduced scalp itching. A study on minoxidil showed that penetration increased with higher ethanol concentrations, reaching maximum penetration at 90% ethanol.

      community Topical finasteride carrier/vehicle

      in Finasteride  135 upvotes 3 weeks ago
      The user is considering making a homemade topical finasteride solution using an ethanol-based carrier. They are inquiring if a solution containing partially denatured ethyl alcohol and benzalkonium chloride is suitable.

      community The best vehicle/carrier for RU58841

      in Treatment  2 upvotes 1 year ago
      The conversation is about the best vehicle for RU58841, comparing trichosol and Garnier/Vichy Stemoxydine, avoiding propylene glycol (PG) or ethanol due to previous scalp damage. The user is also seeking sources for these products in the EU.

      community Best vehicle for topical melatonin?

      in Treatment  6 upvotes 3 years ago
      The conversation is about creating a homemade solution for hair loss treatment, specifically asking for advice on what base to use for topical melatonin. No specific treatments were discussed.

      community Pyrilutamide solution question

      in Research/Science  9 upvotes 2 years ago
      The conversation is about the stability of pyrilutamide in different solutions. The user is asking if a 70/30 ethanol/pg solution with 4% water will degrade pyrilutamide.

      community Creating Your Own Topicals: A Guide

      in Research/Science  67 upvotes 1 year ago
      Creating a carrier solution for topical hair loss treatments using ethanol, propylene glycol or glycerin, and instructions on creating topical finasteride. Different recipes are provided with varying ratios of alcohol to humectant.

      community Terrible experience with MV Supplements and no support

      in Product  3 upvotes 6 months ago
      A user had a bad experience with MV Supplements when their Pyril powder and ethanol order leaked during shipping, making the products unusable. Despite contacting support and providing evidence, the company's return policy did not allow for a refund or replacement.

      community What solution to use for RU58841?

      in Product  1 upvotes 1 year ago
      The post is about using different solutions for RU58841, a treatment for hair loss. The user is asking for opinions on the effectiveness of different vehicles and dosages.

      community Sandalore: a scientific homemade approch

       20 upvotes 6 years ago
      The post discusses using Sandalore as a potential hair loss treatment, emphasizing precise measurements and safe handling. The user compares Sandalore's effects to Minoxidil and mentions preparing a solution with ethanol and DMSO.

      community Hair Regrowth with Novel Hemp Extract - anyone seen this??

      in Research/Science  19 upvotes 4 months ago
      A user discusses a novel hemp extract for hair regrowth, which showed superior results to finasteride and minoxidil. The formula includes CBD, CBDV, THCV, delta 9 THC, cannabigerol, and cannabinol, combined with menthol, peppermint oil, ethanol, Emu oil, HFA 134A propellant, and dimethicone.

      community How to make topical melatonin?

      in Treatment  1 upvotes 8 months ago
      The conversation is about creating a topical melatonin treatment for hair loss. Specific treatments discussed include Minoxidil, Finasteride, and RU58841.

      community Sublingual topical minoxidil experience

      in Minoxidil  16 upvotes 2 years ago
      A user experienced severe side effects from using topical minoxidil sublingually, including muscle cramps, dizziness, and high potassium levels. They were advised to stop and seek medical help, emphasizing that topical minoxidil is not safe for ingestion due to its alcohol content.

      community Trichosol, polyethylene glycol, and DMSO

      in Minoxidil  3 upvotes 8 months ago
      The user experiences irritation from alcohols in minoxidil and is considering alternatives like trichosol mixed with polyethylene glycol or DMSO. They seek advice on the best nonirritating option.