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FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

Heavy nicotine use can lead to hair thinning and loss, but quitting can reverse these effects. The user noticed significant hair regrowth after quitting vaping.

User shared 16-month progress using finasteride 1 mg/day and minoxidil 5% solution once/day, noting significant regrowth, especially in temporal peaks. Users discussed shedding, side effects, and positive feedback from others.

A user experienced significant hair loss after using Rogaine foam purchased from Amazon, which failed a bleach test for Minoxidil. They discovered that even legitimate Rogaine products might be faulty and advised buying from reputable sources.

User reports seeing fast hair regrowth after 1 month and 12 days using 0.3% Finasteride and 6% Minoxidil. They are considering microneedling and received advice to use a derma stamp.

A user shared impressive hair regrowth results after using 1mg finasteride daily for over a year, with minimal side effects. The user also mentioned taking biotin gummies and experiencing periods of shedding followed by thicker hair growth.

A 35-year-old MTF individual shared their hair recovery journey, using Minoxidil, Dutasteride, Estradiol, Spironolactone, Microneedling, and Exosomes. They recently had a hair transplant and are documenting the healing process.

The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

A user was prescribed 5mg of Finasteride daily for hair loss, which is a higher dose typically used for prostate issues. Many suggest using a pill cutter to reduce the dose to 1mg or less per day, as it is more cost-effective and equally effective for hair loss.

A man shared how his baldness led to reconnecting with his high school crush, resulting in marriage. The conversation includes jokes and varied opinions on balding, with no specific treatments mentioned.

The conversation discusses seeking a stronger treatment than Dutasteride (DUT) for hair loss. Suggestions include combining DUT with RU58841, increasing DUT dosage, and using transgender hormone replacement therapy or testosterone blockers, though some options may have feminizing side effects.

A user started finasteride for hair loss and saw improvement, but is now experiencing shedding and thinning in new areas. They added Nizoral due to dandruff caused by finasteride. Replies suggest that shedding is normal around 6 months and advise to stick with the treatment.

The conversation is about a user's hair regrowth after 8 months of using minoxidil, finasteride, and a derma roller. The user started seeing results after beginning derma rolling, using 0.25% finasteride and 5% minoxidil twice daily.

The user has been on finasteride for over four years without noticeable results and recently added dutasteride and RU58841, but continues to experience hair loss. They are considering stopping all medications due to lack of effectiveness and side effects like extremely dry eyes from dutasteride.

The conversation discusses various treatments for hair loss, including finasteride, minoxidil, dutasteride, microneedling, and checking for nutrient deficiencies. Some users suggest adding hydrocortisone butyrate, low-dose progesterone, or tretinoin to treatment regimens, while others recommend cosmetic solutions like Toppik hair fibers or shaving the head.

A user's 61-year-old father regained a full head of hair after four years on dutasteride for his prostate and five months of weight loss and exercise. The user decided to switch from finasteride to dutasteride and continue exercising, inspired by his father's results.

A user experienced significant hair regrowth using Minoxidil but started shedding hair after switching brands and adding treatments like Topical Finasteride and microneedling. They also faced increased hair loss after using Ketoconazole shampoo and are seeking advice on whether brand switching or the shampoo could be the cause.

User "Mostuls" shared their 4-month hair loss treatment routine, which includes daily oral finasteride, twice-daily topical minoxidil, and microneedling twice a week with no side effects. Other users discussed the specifics of the treatment and expressed positive reactions to the results.

The conversation is about using natural DHT blockers like pumpkin seed oil and saw palmetto extract for hair loss. The user has been using minoxidil, derma rolling, vitamin D, and biotin but is considering finasteride next.

A 26-year-old man embraced baldness, gaining confidence and personal growth, and encourages self-acceptance. Others discussed hair loss treatments like Minoxidil and finasteride, but he did not use them.

The post is about a user who stopped using finasteride for hair loss and shaved his head, receiving positive feedback. The conversation includes discussions on side effects of finasteride, including potential fertility issues, and alternatives like minoxidil, dermarolling, and hair systems.

A user experienced significant hair loss after 6 months of using 0.5mg finasteride daily. Suggestions from others included trying Dutasteride and Minoxidil, getting professional help from a dermatologist, and addressing high iron levels that could be contributing to the hair loss.

The user experienced significant hair thickening after switching from three years of topical Minoxidil and keto shampoo to three months of topical finasteride and derma stamping. They also noted that they're using less than the recommended amount of finasteride, but still seeing great results.

The conversation revolves around the experiences of different individuals with hair loss treatments like Minoxidil, Finasteride, and RU58841. The discussion includes various perspectives on the effects of these treatments, the importance of hair for self-esteem and attractiveness, and the influence of significant others on the decision to use or stop using these treatments.

A user shared their experience with hair loss treatments Minoxidil and Finasteride. They saw improvement but stopped using them, leading to significant hair loss, and are now considering restarting the treatments.

The user "Prudent_Poet_6230" shared progress pictures of their hair regrowth after using finasteride for almost a year. They experienced minimal side effects, with some dryness on their face.

The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

A person realized they were balding when their sister pointed it out and is now using a combination of hair loss treatments including finasteride, minoxidil, microneedling, and plans to add dutasteride and RU58841. Others in the conversation emphasize the importance of honesty about hair loss and caution against an overly aggressive treatment regimen, especially before a hair transplant.

The conversation is about hair loss and the use of finasteride as a treatment. Some users share their positive experiences with finasteride, while others mention side effects they have experienced.

A bald groom was beaten by the family of the bride for wearing a wig. The conversation discusses the cultural stigma around baldness in India and the consequences of deception in arranged marriages.