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      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 1 year ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

      community Is RU558841 actually related to heart issues?

      in Finasteride/Dutasteride  11 upvotes 1 year ago
      RU58841 may cause heart-related side effects like palpitations and chest pain, though evidence is mostly anecdotal. Users report mixed experiences, with some stopping due to side effects and others using it without issues, but concerns about its safety and sourcing remain.

      community Finasteride does deplete important nuero-active steroids

       11 upvotes 3 years ago
      Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

      community 0.25 % fin and 0.25% dut together topically

      in Treatment  3 upvotes 9 months ago
      The user is dissatisfied with the results of using 0.3% finasteride and 6% minoxidil for hair thinning and is considering a topical treatment combining finasteride, dutasteride, minoxidil, melatonin, caffeine, and latanoprost. Another user suggests that high topical concentrations can lead to systemic exposure and recommends using oral dutasteride and microdosing topical finasteride.

      community Naturally high T (1,100+) causing diffuse thinning while on Dut

       22 upvotes 5 months ago
      A 26-year-old male with high testosterone is experiencing diffuse hair thinning despite using a comprehensive treatment regimen including dutasteride, oral minoxidil, RU58841, ketoconazole shampoo, microneedling, and low-level laser therapy. Suggestions include adjusting dutasteride dosage, monitoring iron levels, and consulting a dermatologist for further evaluation.

      community Developed dark circles from Minoxidil

       5 upvotes 5 years ago
      Minoxidil can cause dark circles and skin issues, and users suggest reducing dosage or switching to foam. Supplements like vitamin C, glycine, and MSM may help with collagen production to reduce these side effects.

      community We Need A Solution For The Inflammatory Response related To AGA

      in Research/Science  16 upvotes 2 years ago
      The conversation is about finding a solution for scalp inflammation related to AGA, with the user expressing frustration that Minoxidil and Finasteride do not address inflammation. The user has researched glucocorticoids and topical NSAIDs for reducing inflammation and seeks advice from specialists.

      community 25 years on finasteride - my experience

       943 upvotes 1 year ago
      A long-term finasteride user experienced side effects like sexual dysfunction, dry eyes, muscle weakness, and brain fog, which improved when they stopped the medication. They decided to stop finasteride again, questioning if maintaining hair was worth the negative impact on their well-being.

      community Any growth (been taking iron supplements)

      in Is this regrowth? 1 year ago
      The conversation discusses hair loss treatments, focusing on iron supplements for low ferritin levels and considering finasteride and minoxidil if thinning persists. There is debate over starting with finasteride versus dutasteride, with some users advocating for dutasteride due to its potency, while others caution about potential side effects.

      community Did these tests—any of these linked to diffuse thinning?

       5 upvotes 1 year ago
      A 25-year-old male experiencing diffuse thinning is advised to address high TSH levels and low iron, and consider treatments like finasteride. Weight loss and improved diet are also suggested to potentially help with hair health.

      community finasteride vs "natural" DHT blockers

       10 upvotes 4 years ago
      The conversation discusses challenges in obtaining finasteride in the Netherlands and explores alternatives like natural DHT blockers and topical finasteride. Suggestions include consulting different doctors or dermatologists and considering cost-effective options like cutting higher-dose tablets.

      community 20M, low libido, new ideas to improve it

       5 upvotes 4 years ago
      A 20-year-old male experienced low libido after taking finasteride for 1.5 years and considered switching to topical finasteride. He noticed libido changes with different dosing schedules and questioned if creatine might be affecting his libido.

      community Anti inflammatories as an adjunct treatment

       1 upvotes 8 months ago
      Anti-inflammatories like curcumin, quercetin, and vitamin E may help with hair loss when used alongside treatments like finasteride and dutasteride. Ketoconazole is also noted for reducing scalp inflammation and improving scalp health.

      community Is microneedling worth adding if you're already on fin + min?

       77 upvotes 2 months ago
      Microneedling, when added to finasteride and minoxidil, can enhance hair regrowth, with many users reporting positive results. Some users experience significant improvement, while others see minimal change; consistency and technique may influence outcomes.

      community What’s the view on stemoxydine?

       6 upvotes 1 year ago
      Stemoxydine may work synergistically with minoxidil and finasteride for hair growth, but its effectiveness is debated, with some users experiencing minimal results and concerns about cost. Users suggest sticking to proven treatments like minoxidil and finasteride, while considering stemoxydine as an additional option.

      community Finasteride and manjuice: is yours watery?

       13 upvotes 5 years ago
      A user has been taking finasteride for 7 months and is experiencing watery semen as the only side effect. They are considering taking zinc supplements to improve this condition.

      community Anyone immediately lose hope for gt20029 when they realised it’s developed by kintor

       7 upvotes 8 months ago
      The conversation discusses various hair loss treatments, including minoxidil, finasteride, dutasteride, pyrilutamide, alfatrodial, and nizoral, with a focus on the potential of new treatments like gt20029 and breezula. There is optimism about novel treatments that don't have systemic effects, although skepticism remains about the effectiveness of some new drugs.

      community microneedle, any long term users damage?

      in Microneedling  35 upvotes 2 years ago
      Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

       63 upvotes 2 years ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

      community Verteporfin Phase 1 Human Clinical Trial In The Works - Research

       92 upvotes 1 year ago
      Verteporfin is being discussed for its potential to regrow hair and heal scars, possibly aiding hair transplants or replacing them. Some users are skeptical about its effectiveness, while others suggest combining it with microneedling for better results.

      community Anyone got any regrowth with exosomes?

       2 upvotes 1 year ago
      Exosomes are being considered for hair regrowth after using finasteride and minoxidil, with skepticism about their effectiveness and high cost. Users discuss administration methods like injections and microneedling, but concerns about pricing and potential scams are prevalent.

      community Laser Diode Cap, I already use Oral Fin, Topical Min 5%, Nizoral and Microneedling

      in Treatment  1 upvotes 10 months ago
      The user is seeking advice on maximizing hair growth while using oral finasteride, topical minoxidil, Nizoral, and microneedling, and is considering adding a laser diode cap, topical finasteride, retinol, and caffeine. Suggestions include using tretinoin with minoxidil for better absorption, switching to dutasteride, and considering RU58841 or pyrilutamide.

      community Additional supplements / peptides to maximize finasteride benefit

      in Research/Science  3 upvotes 3 months ago
      The user is using finasteride, HGH, GHK-CU, BPC-157, KPV, biotin/collagen/keratin vitamins, ketoconazole shampoo, and low-dose naltrexone to address hair loss, avoiding minoxidil due to past shedding experiences. Adenosine is discussed as a potential alternative to minoxidil, though it is noted to be expensive and hard to find.

      community Improving the effects of finasteride topic

      in Finasteride/Dutasteride  2 upvotes 1 year ago
      The user has been using finasteride 0.1% and minoxidil 5% for hair loss with some regrowth but seeks improvement. Suggestions include increasing finasteride dosage, using dutasteride, adding dermarolling, or switching to oral medication.