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      community Question for Russians in this subreddit

      in Product  1 upvotes 2 months ago
      The user plans to switch to oral finasteride and oral minoxidil due to insufficient results from PRP, topical minoxidil, and mild DHT inhibitors. They seek advice on purchasing these medications from My.India, questioning its trustworthiness.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 2 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
      Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?

      community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?

      in Treatments  372 upvotes 2 months ago
      Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.

      community Koshine826 - LX-826? machine translation of the news article

      in Product  5 upvotes 3 months ago
      KOSHINE826 is a new anti-hair loss and hair growth solution that claims to effectively control oil, reduce hair fall, and promote real hair growth. It targets androgenetic alopecia by inhibiting DHT and has shown promising results in clinical trials.

      community Anyone else having a bad summer shed?

      in Finasteride/Dutasteride  40 upvotes 3 months ago
      Users are experiencing increased hair shedding despite using treatments like dutasteride, finasteride, minoxidil, hair vitamins, and DHT shampoo. Some note this happens seasonally, while others are concerned their treatments are no longer effective.

      community What blood exams should I do on dut/oral min

      in Chat  1 upvotes 4 months ago
      The user checked iron, ferritin, B12, zinc, testosterone, DHT, and estrogens to understand hair loss causes and the effects of dutasteride. They also noted increased heart rate and paleness with oral minoxidil.

      community Microneedling without any meds - A few worries

      in Microneedling  2 upvotes 4 months ago
      The user has seen great results from microneedling but is worried it might lead to faster balding without medication. They are considering adding Finasteride or Dutasteride to their routine to address underlying DHT issues.

      community 0.5mg eod vs 1mg daily of finasteride

      in Chat  18 upvotes 4 months ago
      The conversation discusses the effectiveness of different doses of finasteride for hair loss, questioning the need for 1mg daily when 0.5mg every other day has a similar impact on scalp DHT. A humorous reply suggests exaggerated side effects.

      community Hair theory Scar tissue and Verteporfin

      in Chat  26 upvotes 4 months ago
      A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

      community Volume boost shampoos end up hurting your hair?

      in Styling  1 upvotes 5 months ago
      Volume boost shampoos, specifically Schwarzkopf Professional Bonacure Collagen Volume Boost Micellar Shampoo, may potentially impact hair due to creatine's effect on DHT. The user likes the shampoo for its gentle nature and thickening effect but is concerned about long-term use.

      community Light therapy helps hair growth (Studies included)

      in Research/Science  22 upvotes 6 months ago
      Red light therapy is scientifically proven to promote hair growth by increasing strand density and thickness, and it's an additional treatment to DHT blockers like minoxidil and finasteride. Some users are skeptical about the cost and effectiveness of commercial devices, despite studies showing benefits.

      community Can aromatase inhibitors make dutasteride/finasteride useless?

      in Finasteride/Dutasteride  9 upvotes 7 months ago
      The conversation discusses using aromatase inhibitors with dutasteride or finasteride for hair loss, which can prevent testosterone from turning into estrogen but may lead to increased DHT and potentially make finasteride less effective. There's concern about proper dosing and side effects like gynecomastia and emotional changes.

      community Can amino acids help with AGA

      in Chat  3 upvotes 7 months ago
      Amino acids like lysine, methionine, and cysteine may help with androgenetic alopecia when taken in high doses along with a DHT blocker. Users discuss combining these with treatments like Minoxidil, finasteride, and RU58841.

      community Do I get a hair transplant at 22?

      in Transplants  11 upvotes 7 months ago
      A user has been using dutasteride and oral minoxidil for hair loss with no change and is considering a hair transplant at age 22. Replies suggest that a transplant is possible if DHT blockers like finasteride are continued, and another user shared a positive personal experience with a transplant at age 20.

      community Is it true that most hair loss treatments fall into one of two categories? If not, what am I missing?

      in Treatment  3 upvotes 7 months ago
      Hair loss treatments are generally categorized as anti-androgens, like finasteride and RU58841, which prevent hair loss by targeting DHT, and growth stimulators, such as minoxidil, rosemary oil, microneedling, and LLLT, which promote hair growth by increasing blood flow and growth factors. The user is seeking to confirm these categories and understand if there are other treatments or mechanisms of action.

      community Anyone have better luck with Dutasteride over Finasteride?

      in Finasteride/Dutasteride  8 upvotes 8 months ago
      The conversation is about someone who has tried various dosages of finasteride for hair loss without success and is considering switching to dutasteride, which reduces more DHT. They are asking if others have had issues with finasteride but found dutasteride to be more effective without problems.

      community Finasteride is Good for Heart Health!

      in Research/Science  119 upvotes 8 months ago
      Finasteride, a hair loss and prostate drug, may also benefit heart health. Some users discuss the potential negative effects of DHT on the heart and the balance between hair loss treatments and heart health.

      community Why do some have no change even on nuclear stacks ?

      in Research/Science  16 upvotes 8 months ago
      Some people see significant hair regrowth using treatments like finasteride and minoxidil, while others experience little to no improvement even with comprehensive treatment plans. Factors such as individual sensitivity to DHT may influence the effectiveness of these hair loss treatments.