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    GlossaryCYP3A4

    enzyme that metabolizes drugs and toxins in liver

    CYP3A4 is an enzyme found in the liver and intestines that plays a crucial role in metabolizing many drugs and toxins in the body. It helps break down substances so they can be more easily eliminated, and its activity can affect how well medications work and their potential side effects.

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      community How does finasteride leave your body?

      in Chat  13 upvotes 7 months ago
      Finasteride is metabolized in the liver and excreted through urine and feces. Users humorously discuss its excretion, with one joking about it being expelled through ejaculation.

      community NootBro Recommendations… How Do We Feel

      in Research/Science  9 upvotes 5 months ago
      The conversation is about hair loss treatments, specifically a stack including topical Ashwagandha, Copper Peptide, Gotu Kola, Ketoconazole, and PDA. One user found Topical and Sub-Q GHK-CU effective.

      community Oral Minoxidil and Grapefruit Juice

      in Research/Science  96 upvotes 1 year ago
      The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

      community How to BECOME a RESPONDER to Fin/Dut if you are not responding

      in Finasteride/Dutasteride  308 upvotes 1 year ago
      The conclusion of this conversation is that the user "DuckSeasonCamelSeasn" found that consuming grapefruit juice prior to taking finasteride or dutasteride helped them become a responder to the medications and regain hair growth. However, there are warnings about potential risks and interactions with other medications, so caution should be exercised.

      community What is your opinion on Dutasteride Mesotherapy

      in Treatment  13 upvotes 4 weeks ago
      Dutasteride mesotherapy was not effective for hair regrowth, leading to consideration of oral or topical dutasteride. Oral dutasteride is suggested as more effective and cost-efficient than mesotherapy, with some users experiencing side effects from finasteride.

      community KX-826: Long-Term Safety Results are out!

      in Research/Science  156 upvotes 3 weeks ago
      KX-826 initially improves hair growth but declines after 24 weeks, with mild itching as a side effect. Combining it with minoxidil and finasteride may improve results, but long-term effectiveness is uncertain.

      community How is there still no consensus on Topical Dutasteride in 2024?

      in Finasteride/Dutasteride  149 upvotes 5 months ago
      The conversation expresses frustration over the lack of clear evidence regarding the effectiveness and systemic impact of topical Dutasteride for hair loss treatment, despite years of discussion. People are criticized for not conducting proper research and for providing contradictory anecdotal claims.

      community Dutasteride 6 months - Should I quit or wait more?

      in Finasteride/Dutasteride  11 upvotes 1 year ago
      The user has been on dutasteride for 6 months, experiencing initial hair health but then shedding and brittle hair, with no improvement. They use minoxidil, ketoconazole, dutasteride, and vitamin D, and are questioning whether to continue treatment despite no results.

      community The theory that explains everything. Please help me make this big!

      in Research/Science  2445 upvotes 3 years ago
      The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.