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GlossarySustained Release (Controlled Release)

drug delivery system releasing medication slowly over time

Sustained Release (SR), also known as Extended Release (ER) or Controlled Release (CR), refers to a drug delivery system designed to release a medication slowly over time. This allows for a more consistent therapeutic effect, reduces the frequency of dosing, and can improve patient compliance by maintaining steadier drug levels in the bloodstream.

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community Topical Finasteride Selection

in Finasteride/Dutasteride 1 upvotes 3 months ago

A user is seeking advice on choosing the right topical finasteride for hair loss, considering different formats (spray, gel, aqueous solution) and brands (Xyon, Ro, Keeps, Hims Rx Hair Loss Serum, Happy Head Topical Rx Serum). They are also concerned about the optimal strength to minimize side effects while using it with topical minoxidil.

community 3 months on minoxidil 5% twice daily and micro microneedling, 2 months on topical finasteride (every other day) and bunch of supplements here and there.

in Progress Pictures 106 upvotes 7 months ago

The user has been using minoxidil 5% twice daily, micro-needling, topical finasteride every other day, and various supplements for 3 months to treat hair loss and has seen positive results. They also mentioned using hair growth tablets, biotin, zinc, and vitamins B and D, but not consistently.

community What if I told you you could have it all back? May 2023 to now

in Progress Pictures 155 upvotes 11 months ago

The conversation is about a user's 7-month hair regrowth progress using finasteride/minoxidil gel, minoxidil foam, ketoconazole shampoo, thickening shampoo and conditioner, biotin supplements, and plans to start using a dermaroller. Replies suggest a new haircut and commend the user's progress.

community two weeks apart — signs of regrowth? 1mg fin ED, 5mg oral min ED, 1ml topical min ED, 2% keto shampoo every three-four days, 0.5mm microneedling once a week. been 1 month and a week since i started the regimen with fin, added min within a week and keto shampoo after a month.

in Progress Pictures 44 upvotes 1 year ago

A user's progress in using medications such as finasteride and minoxidil, along with keto shampoo and microneedling, to treat their hair loss. Replies suggested that the user was seeing positive results quickly, but noted the heavy treatments used may cause extra shedding.

community Kintor has released an investor relations memo regarding Chinese Phase III trials for Pyrilutamide

in Update 53 upvotes 11 months ago

Kintor's Pyrilutamide (KX-826) showed hair growth in Chinese Phase III trials but did not significantly outperform placebo. The treatment was safe with no major adverse reactions reported.

community Massive study on finasteride side effects released

in Finasteride/Dutasteride 83 upvotes 1 year ago

The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

community First patient dosed with Pyrilutamide (Kintor) Phase III

in Research/Science 201 upvotes 2 years ago

First patient dosed with Pyrilutamide (Kintor) Phase III for hair loss treatment. Pyrilutamide differs from approved treatments as it competes with DHT to bind hair follicles, potentially reducing side effects.

community Kintor Has Completed Enrollment in Phase II Clinical Trial of KX-826 (Pyrilutamide) for Treatment of Male AGA Patients in the US

in Update 23 upvotes 2 years ago

KX-826 (Pyrilutamide) being tested in the US for hair loss treatment and that they have found enough people to participate in phase II clinical trials. Other treatments discussed are Minoxidil, finasteride, and RU58841.

community What are your thoughts on Redensyl? 85% success rate?!

in Treatment 6 upvotes 2 years ago

Hair loss discussion mentions Redensyl with 85% success rate and visible regrowth. Users skeptical, prefer Minoxidil, Finasteride, and RU58841.

community Amplifica’s AMP-303 Study Unveils New Hope for Hair Loss Treatments

in Treatment 39 upvotes 1 month ago

AMP-303, a new injectable treatment for androgenetic alopecia, showed promising results in increasing hair count and density with minimal side effects. The treatment demonstrated significant hair regrowth and durability, offering new hope for those with hair loss.

community Update about Hair Follicle Glucose Metabolism: New Clinical Data Collection with Ex-President Of American Board Of Hair Restoration Surgery.

in Research/Science 39 upvotes 4 months ago

David Barreto shared that a London-based research group is conducting a 12-month trial for a new nutraceutical treatment for pattern hair loss, designed with Dr. Carlos Puig. The trial aims to provide robust data, with results expected in 1-2 years, potentially representing a significant advancement since finasteride’s introduction in 1997.

community New Hair Loss Treatment from Kintor Just Hit the Market: KX-826!

in Product 38 upvotes 4 months ago

Kintor Pharmaceutical's new hair loss treatment, KX-826, is entering the market. Users are eager to see its effectiveness before celebrating.

community New drug for hair loss announced by Amplifica

in Research/Science 161 upvotes 1 year ago

Amplifica starting clinical trials for new hair loss drug. SCUBE3 protein discovered, stimulates hair growth, could be alternative to Minoxidil and Finasteride.

community 3 months on the big 4 (liposomal gel min fin, keto shampoo and microneedling 1.5mm weekly) let me know what you think

in Progress Pictures 83 upvotes 1 year ago

A user's progress after 3 months of using the "big 4" hair loss treatments - liposomal gel minoxidil, finasteride, keto shampoo and microneedling; with people providing advice about their own experiences and asking for more information.

community drinking topical minoxidil – extreme hair growth everywhere

in Minoxidil 396 upvotes 2 years ago

At this point. In this conversation, users discussed the risks of drinking topical minoxidil and suggested alternative treatments such as obtaining a prescription for oral minoxidil or finasteride.

community 11 month hair update.. The minoxidil and finasteride really work miracles 😳😳😳

in Progress Pictures 864 upvotes 3 years ago

User "Jordan_cadagan" shares 11-month progress using minoxidil and finasteride for hair growth, with impressive results. Users discuss application methods, ice baths possibly helping, and daily dosages.

community Finally Scalp Folliculitis-Free after 2 Decades of Suffering

in Treatment 59 upvotes 2 weeks ago

A 37-year-old male resolved scalp folliculitis by adopting a low-histamine diet and taking Vitamin A, Zinc, and Fish Oil, leading to better skin health and thicker hair. He warns about the potential toxicity of excessive Vitamin A intake.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 136 upvotes 7 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community Recent Study finds Laser caps are more effective than 5% minoxidil for AGA

in Research/Science 124 upvotes 8 months ago

Laser caps are found to be more effective than 5% minoxidil for treating hair loss, and when combined with minoxidil, they are even more effective. Some users report positive results with laser treatments, while others see no change; the devices are FDA approved, but opinions on their efficacy vary.

community RU-58841 Lung Disease Possibility | Chest pain, "heart issues", etc

in Treatment 24 upvotes 8 months ago

Some users of RU-58841 report cardiovascular symptoms like heart palpitations and chest tightness, which may be linked to its metabolites causing lung disease. The safety of RU-58841 is uncertain due to lack of long-term data and concerns about product purity, especially from gray market sources.

community Bryan Johnson just dropped his anti hair loss formula

in Treatment 339 upvotes 9 months ago

Bryan Johnson shared his hair loss treatment, which mainly relies on minoxidil and finasteride. Some users are skeptical of his results, while others appreciate his efforts in anti-aging and hair loss research.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community The story of RU58841/ PSK3841

in Research 622 upvotes 3 months ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

community Whoever had success with PYRILUTAMIDE, please give us hope outside of 5AR inhibitors.

in Product 7 upvotes 3 months ago

Users discuss using pyrilutamide for hair loss, seeking alternatives to 5AR inhibitors. They mention using minoxidil, ketoconazole shampoo, and RU58841.

community PSA: You guys are paying way too much for your Finasteride and Minoxidil. Here's the cheapest I've found.

in Product 223 upvotes 4 months ago

Finasteride and minoxidil can be obtained cheaply through Mark Cuban's Cost Plus Drugs and Costco's Kirkland brand, respectively, costing about $7.53/month combined. Amazon's RXPass and virtual visits at Dr. B. offer additional savings.

community Can someone explain why it's "dumb" to just drink topical liquid minoxidil?

in Minoxidil 27 upvotes 1 year ago

The conversation discusses the risks and methods of ingesting liquid minoxidil for hair loss. Concerns include dosing accuracy, safety of ingredients, and potential side effects compared to using oral minoxidil tablets.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community New Latanoprost-Based Formula Used by Hollywood Celebrities

in Treatment 25 upvotes 1 year ago

A new Latanoprost-based formula used by Hollywood celebrities to treat hair loss, with the formula containing minoxidil, tretinoin, melatonin, azelaic acid, zinc thymulin, vitamin B6, sandalore and methyl vanillate. It also mentions the potential of offering a combined sublingual minoxidil/oral dutasteride option in the future.

community Pyrilutamide is literally my only hope

in Chat 91 upvotes 2 years ago

Considering treatments for hair loss, including Minoxidil, Finasteride, RU58841, Fluridil and Pyrilutamide. The user is weighing the risks of taking unapproved medication before it has been mass produced.

community Got a microscope camera. Here’s the difference between healthy and miniaturized hair

in Progress Pictures 492 upvotes 2 years ago

A user who shared progress pictures of their scalp using a microscope camera, demonstrating the difference between healthy and miniaturized hair. Various explanations for the cause of this were discussed, such as DHT build-up in scalp sebum causing an autoimmune response leading to inflammation and eventual hair loss, with some suggesting a do-it-yourself treatment involving adding ascorbic acid powder to shampoo.