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GlossaryPhysiological Stress

body's response to factors disrupting its normal balance

Physiological stress, also known as physical or biological stress, refers to the body's response to factors that disrupt its normal balance or homeostasis. This can include physical injuries, illnesses, extreme temperatures, or strenuous exercise. The body reacts by activating the stress response system, which involves the release of hormones like cortisol and adrenaline to help cope with the stressor.

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community 35m 1.5 months on oral fin/min is it too good to be true?

in Progress Pictures 161 upvotes 1 year ago

A 35-year-old man, balding since 18, has seen growth of small, almost white hairs all over his scalp after 1.5 months on oral finasteride and minoxidil. Users suggest sticking with the treatment for a year, adding microneedling, and potentially trying RU58841 or dutasteride.

community hairloss in my 20s has ruined my life.

in Research/Science 373 upvotes 1 month ago

A person in their 20s is struggling with hair loss, using treatments like minoxidil and finasteride. Suggestions include self-improvement, therapy, hair transplants, and focusing on acceptance and confidence.

community Minoxidil actually reduces wrinkles

in Research/Science 208 upvotes 4 days ago

Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 74 upvotes 5 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Dermarolling is a bit sad innit?

in Microneedling 232 upvotes 3 years ago

Hair loss treatments discussed include dermarolling, minoxidil, finasteride, and RU58841. Some users find dermarolling sad, while others mention the complexity of biological systems and limited research funding for hair loss.

community Topical spironolactone - anti androgen

in Research/Science 10 upvotes 2 years ago

User asks about topical spironolactone experience. Two studies show it as promising anti-androgen treatment, with 5% cream available on Minoxidilmax website.

community Don't give up! 9 months on Minoxidil

in Progress Pictures 392 upvotes 7 months ago

A trans man shared progress pictures showing significant hair regrowth after 9 months on oral Minoxidil and 1.5 years on finasteride. He encourages others to stick with their treatments despite initial setbacks.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 134 upvotes 8 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community Reflex Hyperandrogenicty: How I recovered from it

in Treatment 1 year ago

The user experienced severe hair shedding from RU58841 and recovered by stopping its use and starting treatments including Minoxidil, Rosemary Verbenone, Stemoxydine, Aminexil, copper peptide serum, and specific shampoos. They also consistently used oral Finasteride and plan to try Minoxidil 10%.

community Hair loss and ethnicity - Caucasian men the most likely to experience hair loss

in Chat 17 upvotes 2 years ago

The conversation discusses how Caucasian men are more likely to experience hair loss due to genetic predisposition, with factors like the androgen receptor on the X chromosome playing a significant role. The user also expresses confusion about the evolutionary reasons for hair loss, especially in colder climates where it would seem beneficial to retain hair for warmth.

community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

in Research/Science 126 upvotes 2 years ago

The conversation discusses various factors affecting hair loss, not just DHT, and mentions treatments like Minoxidil, finasteride, and melatonin. Some users report personal experiences with these treatments and hormone tests, while others speculate on the role of hormones like prolactin and cortisol in hair loss.

community My routine that i think is everything you could possibly do to stop further hairloss.

7 upvotes 6 years ago

Finasteride is essential for hair loss prevention, while minoxidil is optional. Additional treatments include a natural shampoo, a healthy diet, scalp massages, microneedling, laser therapy, and supplements like fish oils and biotin.

community If ancient hunter gatherer women had just selected for men with hair we wouldn't be in this mess

in Satire 128 upvotes 1 day ago

Hair loss is humorously blamed on ancient selection preferences, with discussions on genetics and societal norms. Treatments like finasteride are mentioned as modern solutions.

community Can someone explain the science behind why Finasteride doesn't stop you from losing regrown hairs from minoxidil?

in Minoxidil 100 upvotes 3 weeks ago

Finasteride prevents further hair loss by blocking DHT, while minoxidil stimulates hair growth by prolonging the active phase of hair follicles. Stopping minoxidil can lead to loss of regrown hair because finasteride does not address the same growth mechanism.

community Just checked my hormones before starting Fin

in Finasteride/Dutasteride 5 upvotes 1 month ago

A user is considering starting finasteride for hair loss and shares their hormone levels, with others suggesting checking SHBG and discussing potential side effects. Some recommend starting with 0.5 mg finasteride, while others suggest considering dutasteride.

community Red Light Therapy: Cheap Chinese LED caps are better than $3000 laser caps

in Research/Science 39 upvotes 1 month ago

Affordable 92-LED caps may be more effective for hair growth than expensive 270-laser caps due to higher power output and irradiance. The LED caps deliver more energy to the scalp, making them a cost-effective alternative for red light therapy.

community Adding caffeine to topical minoxidil

in Research/Science 4 upvotes 2 months ago

Adding caffeine to topical minoxidil is unlikely to enhance its effectiveness, with most users agreeing it has minimal impact. The main treatments discussed are minoxidil and finasteride, with some users adding other ingredients like azelaic acid and retinol.

community Balding at the age of 17 years old

in Chat 8 upvotes 3 months ago

A 17-year-old experiencing hair loss is using Minoxidil but is hesitant about Finasteride due to potential side effects. Others recommend Finasteride for its effectiveness and suggest alternatives like vitamins and derma rollers.

community Pyrilutamide ,the molecule’s true nature

in Research 302 upvotes 4 months ago

Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

community 9 months of minoxidil , finasteride, spironolactone, estradiol

in Progress Pictures 61 upvotes 5 months ago

User shared progress pictures after 9 months of using minoxidil, finasteride, spironolactone, and estradiol for hair loss. Significant regrowth was noted, especially after starting estradiol.

community Guys maybe high cholesterol and hair loss are related

in Chat 6 months ago

High cholesterol may accelerate hair loss by reducing blood flow and increasing DHT levels. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community 21 months on topical minoxidil and full HRT

in Transgender 214 upvotes 7 months ago

The conversation is about a transgender individual's experience with hair regrowth using topical minoxidil and hormone replacement therapy (HRT), expressing concern about the slow growth and thin appearance of their hair. Some responses encourage patience and highlight the variability of results, while others discuss the role of HRT and its effects.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 8 months ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

community 2 year progress | 1mg fin daily and topical min twice daily

in Progress Pictures 955 upvotes 9 months ago

A user shared a 2-year hair regrowth progress using 1mg finasteride daily and topical minoxidil twice daily, with noticeable thickening after 7 months. Other users discussed the commitment required and potential side effects, but the original poster experienced no side effects.

community Will my liver get destroyed long term on this stack ??

in Chat 15 upvotes 10 months ago

A user is considering a long-term hair loss treatment stack including Dutasteride, Finasteride, and oral Minoxidil, and is concerned about potential liver damage. Some responses suggest the stack is excessive, while others believe it's not harmful to the liver, but recommend regular blood work to monitor health.

community Another clueless guy fearmongering and spreading misinformation

in Chat 251 upvotes 10 months ago

The conversation discusses hair loss treatments, with some users advocating for finasteride and minoxidil, while others express concerns about potential side effects of finasteride. A social media influencer is criticized for promoting scalp massages and minoxidil over finasteride, which some believe is misinformation.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community 5 months oralfin, topmin, dermarolling

in Progress Pictures 858 upvotes 1 year ago

The user "ninezske" shared their progress pictures of hair regrowth after using oral finasteride, topical minoxidil, and dermarolling. Other users commented on the results and discussed the effectiveness of minoxidil and finasteride.

community 6 months on Pyrilutamide- no results

in Treatment 20 upvotes 1 year ago

A user applied pyrilutamide for 6 months without hair regrowth and is considering stopping due to cost and lack of results. Another user suggests switching to finasteride, which is cheaper and has shown regrowth for them.

community No fin/no min protocol. Pictures were 4.5 years apart. January 2019-June 2023. I am 28 years old was 23 in the first picture.

in Progress Pictures 3 upvotes 1 year ago

The post is about a user's progress pictures of their hair loss over a span of 4.5 years. They did not use finasteride or minoxidil for their hair loss treatment.