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      community 1 year on fin. No results. I give up.

      in Finasteride/Dutasteride  43 upvotes 2 years ago
      A user who has been taking finasteride, minoxidil, and microneedling for one year with no results, and the replies discuss other treatments, including dutasteride, which is feared due to potential side effects.

      community PYRILUTAMIDE KX-826 experience

      in Research/Science  98 upvotes 2 years ago
      A user's experience with the hair loss treatment Pyrilutamide KX-826, which has resulted in some side effects and shedding. The conversation also includes advice for baseline pictures and trying treatments for at least 6 months.

      community dutasteride 9 months, nonstop hair loss

      in Finasteride/Dutasteride  31 upvotes 2 years ago
      Experiencing continual nonstop hair loss despite using dutasteride for 9 months, and the possible causes behind it being discussed such as nutritional deficiencies, elevated cortisol, vitamin D deficiency or other problems. Other solutions such as minoxidil and finasteride have been suggested.

      community Opinions on Scalp fibrosis and DHT?

      in Research/Science  9 upvotes 2 years ago
      The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

      community My strong recommendation for those shedding hair

      in Treatment  94 upvotes 3 years ago
      A user with aggressive male pattern baldness found that topical melatonin significantly reduced their hair shedding to 1 or 2 hairs per day and noticed some thickening of side hair. They tried many treatments like finasteride and minoxidil with little success, but topical melatonin showed immediate results in reducing hair loss.

      community Dermarolling is a bit sad innit?

      in Microneedling  232 upvotes 3 years ago
      Hair loss treatments discussed include dermarolling, minoxidil, finasteride, and RU58841. Some users find dermarolling sad, while others mention the complexity of biological systems and limited research funding for hair loss.

      community Maintaining hair until Breezula without Fin

      in Treatment  6 upvotes 4 years ago
      A 21-year-old male experienced side effects from topical finasteride and is seeking alternative treatments to maintain hair until Breezula is available. He is considering using minoxidil, Nizoral, micro-needling, and vitamin D supplementation, and may try CB or RU58841 if necessary.

      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  36 upvotes 5 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community Kintor Pharmaceutical Announces AR-PROTAC (GT20029) Approved for Acne and Androgenic Alopecia Clinical Trials in China

      in Technology  15 upvotes 3 years ago
      The conversation discusses the approval of Kintor Pharmaceutical's AR-PROTAC (GT20029) for clinical trials in China for acne and androgenic alopecia. One user expresses optimism about new treatments being developed and seeks clarification on how the new drug works, specifically if it temporarily degrades the AR protein to reduce DHT sensitivity in hair follicles.

      community Androgen degraders for hair loss

      in Research/Science  58 upvotes 2 months ago
      The conversation discusses androgen receptor degraders for hair loss, highlighting their potential advantages over traditional AR blockers like RU58841 and pyrilutamide. Concerns about the safety and cost of these treatments are also mentioned.

      community So... any chinese suppliers for real pyri?

      in Research/Science  6 upvotes 4 months ago
      The conversation discusses sourcing pyrilutamide from China for hair loss treatment, highlighting its potency compared to other AR antagonists like bicalutamide and RU58841. The user expresses interest in trying pyrilutamide despite mixed results in clinical trials.

      community The closest thing to a cure before hair cloning or genetic via?

      in Treatment  9 upvotes 1 year ago
      The conversation discusses using finasteride or dutasteride to reduce DHT, CosmeRNA to target androgen receptors, and Minoxidil as a vasodilator for hair growth. The regimen aims to maintain hair by addressing DHT-AR ratio and continuous Minoxidil use.

      community Can you beat this 104 year old man‘s hair count?

      in Styling  745 upvotes 2 years ago
      A 104 year old man's impressive head of hair and speculations about how he has been able to maintain it; treatments such as minoxidil, finasteride, RU58841, dutasteride, 5-AR blockers, and other supplements are discussed.

      community Silicon Valley backed company aims to cure hair loss

      in Technology  51 upvotes 2 years ago
      A Silicon Valley-backed company aims to cure hair loss. Exciting advancements include mRNA therapies, gene editing, hair cloning, AR degraders, anti-androgens, cell-based rejuvenation, and AI-based drug discovery, with hopes for FDA approval of GT20029 within 10 years.

      community Ultimate Stack without nuking your gender (you'll go broke)

      in Treatment  83 upvotes 4 days ago
      A hair loss treatment plan includes finasteride, dutasteride, RU58841, pyrilutamide, minoxidil, and microneedling to inhibit DHT and promote hair growth. It also recommends supplements like Reishi and Lion’s Mane mushrooms, and a shampoo with ketoconazole, caffeine, and melatonin.

      community abusing caffeine boosts DHT levels!

      in Research/Science  1 upvotes 1 month ago
      Caffeine intake may increase DHT levels, but its impact on hair loss is minimal compared to genetic factors. Excessive caffeine can cause health issues, and its effects on hair loss are not directly applicable to humans based on rat studies.

      community Spironolactone or bicalutamide prescription

      in Treatment  4 upvotes 1 year ago
      The conversation is about someone seeking a doctor in the EU who prescribes spironolactone or bicalutamide for female pattern hair loss, as they are having difficulty finding treatment options beyond Minoxidil in Austria. They are asking for recommendations and are open to direct messages for assistance.

      community Topical Pyrilutamide - Hormone Panel

      in Treatment  2 upvotes 1 year ago
      The user used 0.5 mL of 0.5 mg of Pyrilutamide for 60 days for hair loss, but didn't notice any hair growth. They shared their hormone panel results and are seeking advice on next steps.

      community All Drugs in Clinical Trials in 2023

      in Research/Science  68 upvotes 1 year ago
      12 companies having drugs or therapies in clinical trials during 2023, with various molecules and phases of trial; the probability that some may fail; and progress being made in the field.

      community GT20029. Kintor Pharma’s Product

      in Research/Science  13 upvotes 2 years ago
      The conversation discusses GT20029, a compound by Kintor Pharma that degrades androgen receptors and is in trials, with potential as a hair loss cure. Another promising treatment mentioned is an antibody that blocks prolactin and has shown positive results in macaques.