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      community The expected timeline for PP405 - Next update at AAD Annual Meeting in March 2026 ?

       34 upvotes 8 months ago
      A new hair loss treatment, PP405, showed promising Phase 2a results with 31% of patients experiencing over 20% hair density increase without systemic absorption, avoiding hormonal side effects. The treatment is expected to be expensive, with Phase 3 trials starting mid-2026, and there is skepticism about the data's strength.

      community Pp405 phase 2a clinical results

       37 upvotes 1 year ago
      PP405 shows initial promise for treating androgenetic alopecia, with safety confirmed in early trials, but skepticism remains due to limited data. Further trials are needed to determine its true efficacy and potential market impact.

      community ABS-201 Trial - What should I know going in

      in Research/Science  28 upvotes 6 months ago
      The conversation is about a user preparing to join the ABS-201 clinical trial for hair loss treatment, which involves a prolactin inhibitor. The user plans to update others on their progress if enrolled.

      community Found a slide summary for PP405

       35 upvotes 5 months ago
      PP405 shows promise in stimulating new terminal hair growth by activating dormant follicles, with no systemic adverse effects observed in a short-term trial. However, long-term efficacy remains unproven, and further trials are needed to confirm its potential as a hair loss treatment.

      community Today was Last update on pp405

       109 upvotes 1 year ago
      A new hair loss treatment, PP405, is moving from phase 2A to 2B in clinical trials, sparking discussions about its potential to regrow dormant hairs and its impact on existing treatments like Minoxidil and finasteride. Some users express skepticism, while others are hopeful about its future effectiveness.

      community My summation of PP405 - looks promising

       210 upvotes 1 year ago
      PP405 shows promise for hair regrowth by manipulating stem cell characteristics and lactate dehydrogenase, with Phase 2a trials pending. Google Ventures' $15M investment suggests confidence, but results and market availability remain uncertain.

      community Haircafe slams pp405 presentation. Are results really that bad?

       64 upvotes 5 months ago
      PP405 shows promise in activating dormant hair follicles and increasing hair counts but lacks detailed efficacy data compared to minoxidil and finasteride. Opinions are mixed, with some optimism and skepticism about its effectiveness.

      community PP405 could be released before GTA 6

      in Chat  133 upvotes 9 months ago
      PP405 is discussed as a potential hair loss treatment, but its effectiveness and safety are uncertain. Some users express skepticism, while others are hopeful, comparing it to existing treatments like Minoxidil and Finasteride.

      community If PP405 works it will be fkn impossible to buy it.

       103 upvotes 10 months ago
      PP405 is a potential hair loss treatment that may activate dormant hair follicles, but there are concerns about its effectiveness, cost, and side effects. Users discuss treatments like minoxidil, finasteride, and RU58841, expressing skepticism about PP405's long-term success and accessibility.

      community is there any news about pp405 please

       10 upvotes 1 year ago
      There is no new information on pp405, with data collection expected to finish by the end of 2025. Users are discussing the timeline for data analysis and completion of Pelage Pharmaceuticals' phase 2 study.

      community PELAGE PHASE 2 TRIALS FOR PP405 - Volunteers Needed

       24 upvotes 2 years ago
      PP405 is a topical gel being tested for hair regrowth in adults with androgenetic alopecia. Volunteers aged 18-55 are needed for a 16-week trial in several US locations.

      community By when would pp405 be available in the grey market?

      in Chat  15 upvotes 5 months ago
      PP405 might take 3-4 years to be available, but some claim Everychem offers a similar product, though its effectiveness is debated. Users discuss the risks of using untested grey market products and the potential for adverse effects.

      community HT booked, taking finasteride and losing ground?

       1 upvotes 6 months ago
      The user is concerned about hair loss despite taking finasteride and has a hair transplant scheduled. They experience scalp itching and burning, which hasn't been relieved by various treatments, and another user suggests using ghk-cu & ahk-cu serum and Koshine kx-826/pyrilutamide for relief.

      community Thoughts on this? Supposed everychem pp405 results after 2 weeks

       17 upvotes 5 months ago
      PP405 is being discussed as a promising hair loss treatment, potentially effective when combined with minoxidil and pyrilutamide. Some users are skeptical about rapid hair regrowth claims, while others are considering alternatives like GT20029 and pyrilutamide instead of finasteride.

      community 14 month progress on Oral Min/dutasteride

       32 upvotes 1 month ago
      The user shared 14-month progress using oral minoxidil and dutasteride, noting healthier hair corners after switching from finasteride. They plan a future hair transplant for a lower hairline.

      community How many years can we expect PP405 to be on the market

       11 upvotes 1 year ago
      PP405 is expected to be on the market between 2027 and 2030, with phase 3 trials starting in 2026. There is skepticism about its fast-tracking due to its cosmetic nature, and it may appear on the gray market sooner.

      community P-1075: a BETTER version of Minoxidil

      11 months ago
      P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

      community Getting PP405. Now…. or as soon as possible

       147 upvotes 1 year ago
      People are discussing obtaining and testing PP405 for hair loss treatment, with concerns about its purity and effectiveness. Some are considering delaying hair transplants, while others suggest using existing treatments like finasteride and minoxidil.

      community How long are Pelage going to milk the phase 2a results of PP405?

       21 upvotes 7 months ago
      PP405, a potential hair loss treatment, is facing delays in releasing Phase 2 results, causing frustration among users who compare it to past failed treatments. Despite skepticism, some remain hopeful about PP405's future, while others discuss alternative treatments like Clascoterone and its expected market release.

      community If PP405 doesn't work then why would Pelage continue with trials?

       44 upvotes 1 month ago
      PP405 is still undergoing trials despite skepticism about its effectiveness. Some believe it shows potential for hair regrowth, possibly in combination with other treatments like minoxidil or finasteride, while others are doubtful due to past disappointments with similar products.

      community Any chemists want to manufacture PP405 / JXL069? (Steps inside)

       114 upvotes 1 year ago
      The conversation discusses the potential of PP405 as a hair loss treatment, with some users expressing skepticism and others hopeful about its development. There is also mention of other treatments like Minoxidil, Finasteride, and Pyrilutamide, with users debating the effectiveness and safety of self-experimentation versus waiting for clinical trial results.

      community Is PP405 formula available in grey market?

       16 upvotes 1 year ago
      The conversation is about the availability of the PP405 formula for hair loss treatment, with mentions of finasteride and its side effects. Users discuss the potential of obtaining the formula through unofficial channels and the challenges related to its genetic sequence and delivery method.

      community Will Pp405 be the Ozempic of bald Guys

      in Research/Science  101 upvotes 7 months ago
      PP405 is being discussed as a potential hair loss treatment, possibly more effective than minoxidil. There are concerns about its effectiveness and product contamination, but some users report early signs of hair regrowth.