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      community The story of RU58841/PSK3841

      in Research/Science 2 months ago
      RU58841, an anti-androgenic compound, showed early promise for treating alopecia but faced challenges after its patent in 1997. Despite advancing to Phase II trials, safety concerns and financial struggles led Aventis to abandon its development. Proskelia, which later merged into ProStrakan, couldn't prioritize the drug, leading to its eventual stagnation and failure to reach the market.

      community FOL005 claims it's better than Finasteride and Minoxidil.

      in Technology  183 upvotes 3 months ago
      FOL-005 claims to be more effective than Minoxidil and Finasteride but lacks anti-DHT properties, leading to potential reduced efficacy over time. Concerns are raised about misleading marketing and the safety of alternative treatments like Pyrilutamide and Clascoterone.

      community Ketoconazole mesotherapy plausible?

      in Ketoconazole  9 upvotes 6 months ago
      The conversation discusses using ketoconazole, an anti-androgen, for hair loss and whether mesotherapy with dermarolling could enhance its absorption into the scalp. The user questions if the typical 2% ketoconazole shampoo dose would be effective when used after dermarolling to target androgen receptors in the scalp.

      community Pyrilutamide and RU alternatives?

      in Treatment  1 upvotes 1 month ago
      Pyrilutamide is officially available for purchase, and users suggest Fluridil as an alternative topical anti-androgen. Some users report positive results with pyrilutamide from Koshine.

      community RU58841 in Pumpkin Seed Oil (PSO)

      in Treatment  2 upvotes 4 months ago
      A user is seeing good results with RU58841 for hair loss, noting reduced shedding and thicker hair. They plan to use pumpkin seed oil as a solvent to avoid water content, which they believe reduces the effectiveness of anti-androgens.

      community Recommend me Shampoo or Saw Palmetto?

      in Chat  1 upvotes 5 months ago
      A 24-year-old male experiencing increased hair thinning and shedding recently started using rosemary and castor oil, microneedling, and an anti-dandruff shampoo. He is considering adding Saw Palmetto and seeks recommendations for a good shampoo.

      community Tretinoin, any good, what’s your experience

      in Research/Science  22 upvotes 5 months ago
      The conversation discusses using tretinoin for hair loss and skincare. Users share experiences, noting tretinoin's effectiveness in combination with minoxidil for hair and its proven benefits for anti-aging skincare.

      community Fin is killing my eyes. Alternatives?

      in Treatment  6 upvotes 7 months ago
      A user experienced severe dry eyes as a side effect of using topical and oral Finasteride for hair loss and is seeking alternative treatments. They are considering other anti-androgens like Dutasteride, RU58841, Pyrilytamide, and Fluridil, despite mixed results and potential side effects.

      community 3 Doctors 3 Diagnoses: Please help.

      in Treatment  4 upvotes 8 months ago
      A user experiencing hair loss received three different diagnoses: androgenic alopecia, traction alopecia, and scarring alopecia, and tried treatments like minoxidil and finasteride without success. They are considering dutasteride but were advised to seek anti-inflammatory medication instead.

      community Does low HGH leading to hairloss?

      in Research/Science  13 upvotes 9 months ago
      The user experiencing diffuse hair loss is using various treatments including RU58841, finasteride, minoxidil with tretinoin, anti-hair loss shampoo, and microneedling, and is considering adding peptides TB500, BPC157, and GHK-Cu. They have low growth hormone levels and are questioning its impact on hair loss, while another user suggests androgenic alopecia and androgens are likely the main cause of hair loss.

      community Is there a consensus on a "best conditioner" to use?

      in Research/Science  12 upvotes 9 months ago
      The conversation is about finding the best conditioner for hair loss, with a mention that Ketoconazole shampoo is recommended for reversing hair loss. Users suggest that most "hair growth" conditioners are ineffective and discuss using anti-dandruff conditioners with piroctone olamine.

      community Trans: Do I need to use Finnasteride?

      in Transgender 1 year ago
      A transgender individual is starting spironolactone and estradiol for hormone replacement therapy (HRT) and is considering adding finasteride to help with hair loss. They are also planning to use minoxidil and microneedle, but are unsure if they need to use another anti-androgen or more aggressive treatments. A respondent advises against using pyri and suggests waiting to see if the HRT alone is sufficient before becoming dependent on minoxidil.

      community anyone else see progress? or am i tripping

      in Is this regrowth?  53 upvotes 1 year ago
      User sees hair regrowth progress after 3 months using minoxidil, finasteride, derma rolling, keto shampoo, scalp massaging, and anti-thinning shampoo/conditioner. Others agree there's visible improvement.

      community I just went to a dermatologist and there were many red flags about him.

      in Treatment  13 upvotes 1 year ago
      A user visited a dermatologist for hair loss concerns and was prescribed a hair lotion called "Lotion revolotion evdermia," which is meant for hair toning, hydration, and anti-aging, not regrowth. The user found the dermatologist's behavior and the prescription to be questionable.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  735 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community Homemade topical spironolactone

      in Research/Science  26 upvotes 2 years ago
      The potential effectiveness of homemade topical spironolactone in treating hair loss, with studies suggesting it is more effective than finasteride and even minoxidil when used as monotherapy. The conversation also mentions that other anti-androgens are being developed which may soon hit the market.

      community Silicon Valley backed company aims to cure hair loss

      in Technology  51 upvotes 2 years ago
      A Silicon Valley-backed company aims to cure hair loss. Exciting advancements include mRNA therapies, gene editing, hair cloning, AR degraders, anti-androgens, cell-based rejuvenation, and AI-based drug discovery, with hopes for FDA approval of GT20029 within 10 years.

      community Is Sulforaphane really an option?

      in Chat  7 upvotes 3 years ago
      The conversation discusses the potential benefits of Sulforaphane for hair growth, with a suggestion to grow broccoli sprouts for the best results. One user doubts its effectiveness for hair loss but notes its anti-cancer and hormetic benefits.

      community Anyone here using both Alfatradiol and Fluridil?

      in Treatment  7 upvotes 3 years ago
      User asks if stacking Alfatradiol and Fluridil is effective for hair loss. Alfatradiol is a weaker, topical 5ar inhibitor, while Fluridil is an anti-androgen preventing DHT binding to hair follicles.

      community Korea launches 1st OTC hair loss drug

      in Treatment  31 upvotes 3 years ago
      Korea launched its first OTC oral hair loss drug, dexpanthenol B5. Users discuss its anti-oxidative and anti-inflammatory effects but note a lack of efficacy studies.

      community The Big Fat Layer / Remedies: Cetirizine

      in Treatment  12 upvotes 3 years ago
      Treating hair loss with various remedies, such as Cetirizine and the Big3 complex (minoxidil, finasteride, and RU58841), which have properties like adipogenic, anti-fibrotic and anti-inflammatory. References to research studies are also included.

      community Dutasteride questions

      in Finasteride/Dutasteride  6 upvotes 3 years ago
      Switching to dutasteride as a hair loss prevention treatment, along with minoxidil, dermarolling and nizoral shampoo, and the potential benefits and side effects of using finasteride and/or dutasteride in combination with topical anti-androgens like RU58841.

      community Hopefully a logical question regarding dermarolling.

      in Microneedling 4 years ago
      A user discusses using dermastamping for hair loss and questions the timing of applying a mixture of peppermint oil, spearmint oil, rosemary oil, and castor oil due to their anti-inflammatory effects. They wonder if waiting 10 hours after stamping would be more effective.