Search

for
Search:

Did you mean 5ARD?

Glossary5α-reductase deficiency (5ARD)

genetic condition impairing testosterone conversion to dihydrotestosterone (DHT)

5α-reductase deficiency is a genetic condition where the body lacks sufficient levels of the enzyme 5α-reductase, which is crucial for converting testosterone into dihydrotestosterone (DHT). This deficiency can lead to atypical development of male genitalia in utero and can affect secondary sexual characteristics during puberty.

Related Terms

Sort by

Community Join

30 / 44 results

community Anyone have success with fenugreek?

Bigd990001 in Technology 10 upvotes 4 years ago

Fenugreek has mixed reviews for hair loss, with some reporting success and others experiencing worsening conditions. Few people have shared their experiences online.

community Scientists in Japan develop a new technique to reverse balding by transplanting a special kind of hair follicle cell into a patient's scalp

joecam in Treatment 189 upvotes 4 years ago

A new technique developed by scientists in Japan to reverse balding using hair follicle cell transplants, and the discussion around the effectiveness of this approach compared to other treatments such as Minoxidil, finasteride, RU58841, Replicel, and Hairclone.

community Is this true? Is long term taking fin harmful to the liver?

AccomplishedDepth820 in Chat 127 upvotes 1 year ago

The conversation discusses whether long-term use of finasteride (Fin) is harmful to the liver, with various opinions on side effects and comparisons to other substances. Specific treatments mentioned include finasteride, minoxidil (Min), and RU58841 (RU).

community A warning to those thinking about using Dutasteride

y3pkm8 in Finasteride/Dutasteride 99 upvotes 4 years ago

The potential risks of long-term use of Dutasteride and how it may be linked to elevated liver enzymes, cholesterol levels, and decreased testosterone. Alternative treatments such as Finasteride and RU58841 were also discussed.

community What factors cause more regrowth for MTF people with hormone replacement therapy?

mouse9001 in Transgender 6 upvotes 1 year ago

Hair regrowth in transfems is more effective due to hormonal changes, specifically estrogen, which keeps hair in growth phase longer. Treatments mentioned include anti-androgens, sex hormones, and DHT blockers like finasteride.

community Why I’d advise my teenage son to take propecia (opinion)

Raybones008 in Finasteride/Dutasteride 6 upvotes 4 years ago

The post argues for teenage use of finasteride to prevent hair loss, citing minimal side effects and personal success. Replies criticize the advice, highlighting potential developmental risks and questioning the safety of finasteride for teenagers.

community 50% test increase after 18 months of taking DUT

stykztherealone in Update 57 upvotes 6 months ago

A user reported a 50% increase in testosterone after 18 months of taking dutasteride for hair loss. The conversation includes skepticism about the reliability of single testosterone tests and questions about estrogen levels.

community Received Kintor’s KX-826 Today

Rude_Jellyfish9028 in Product 84 upvotes 6 months ago

A user received Kintor’s KX-826/Pyrilutamide and shared initial impressions, noting concerns about the product's labeling and marketing. Other users discussed the legitimacy of the product, its effectiveness, and compared it to other treatments like Minoxidil and Finasteride.

community Almost 2 months on fin / nizoral shampoo / microneedling 1x week

RevolutionaryMeat959 in Progress Pictures 390 upvotes 1 year ago

User shares progress after 2 months using finasteride, nizoral shampoo, and microneedling for hair loss. Comments discuss early treatment, results, and differing opinions on starting treatments.

community Why is dht bad for scalp hair but good for hair on the rest of body?

What_is_69 in Satire 109 upvotes 1 year ago

The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hair follicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.

community Is it possible for Dutasteride to make one mentally slow?

naenaefinna in Chat 22 upvotes 8 months ago

Dutasteride may cause mental fog, vision blurriness, and sleep issues. Users suggest trying topical versions of the drug to mitigate side effects.

community Testosterone and Androgenetic Alopecia

onurtherebel in Chat 9 upvotes 3 years ago

How androgens, including testosterone, can cause hair follicles to miniaturize in people with sensitivity to androgens, and treatments such as finasteride, dutasteride, minoxidil, RU58841, or fluridil may be used in combination for long-term treatment.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

obafootballinstinct in Research/Science 136 upvotes 6 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community DHT/Testosterone levels in scalp Fin VS Dut.

Glad-Conference-3323 in Finasteride/Dutasteride 66 upvotes 6 months ago

Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

community Ultimate DHT/finasteride microdosing graph to replace the commonly one referenced on forums

hair4tomo in Finasteride/Dutasteride 209 upvotes 4 years ago

Hair loss treatments, specifically, discussing the effectiveness and side effects of finasteride, minoxidil, and RU58841 in various microdoses. It also includes an updated graph which provides information on how different doses affect DHT levels, scalp skin and serum androgen levels, as well as hair count.

community Connection between finasteride and nafld?

Ok_Bumblebee_8071 in Research/Science 4 upvotes 5 months ago

Finasteride may affect liver function and cortisol levels, potentially linking it to non-alcoholic fatty liver disease (NAFLD). More research is needed to understand this connection fully.

community DHT and 5AR respect post, it's importance within the brain

DapperDHT in Research/Science 111 upvotes 11 months ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community 1 Year on Finasteride - Here's what I think

TraditionalCoffee in Finasteride 86 upvotes 5 years ago

A user shared their experience after one year on Finasteride, noting both positive effects on hair retention and minor side effects like reduced libido and high blood pressure. They also emphasized the importance of quitting porn to improve sexual health and mentioned using Viagra to boost confidence.

community Debunking the "Adverse metabolic consequences of dutasteride"

beardedthanos in Research/Science 40 upvotes 3 years ago

Dutasteride is more effective than finasteride, has neuroprotective benefits, and may prevent acne. Despite initial concerns about metabolic effects, further research suggests it is safe for most users, especially if not hypogonadal.

community Discussion: High DHT levels while on Fin+Dut with substantial progress (pics)

revolutionary_sperm in Progress Pictures 63 upvotes 2 years ago

A user's experience with using 5AR inhibitors (Finasteride and Dutasteride) in combination with Minoxidil foam and microneedling, which resulted in substantial improvements to their crown density and hairline, despite high systemic levels of testosterone and dihydrotestosterone.

community Finasteride only reduces scalp DHT by ~40%. Why does it work?

andreas_jacob in Finasteride/Dutasteride 37 upvotes 1 year ago

How Finasteride and Dutasteride help reduce hair loss by reducing the amount of DHT in scalp areas, as well as discussing factors such as sensitivity to DHT, 5α-reductase expression in different parts of the hair follicle, and scalp tension.

community 18->24 six years of Fin and Minox…. I guess we can’t all be winners 😭

EgyptStar81 in Progress Pictures 572 upvotes 2 years ago

A user named "EgyptStar81" who has been dealing with hair loss since age 15 due to genetics, chemotherapy and finasteride/minoxidil treatment. Possible solutions such as dutasteride, oral minoxidil, hair transplants and extensions were suggested.

community Cure/better treatment options in the future

Vrxdical in Chat 11 upvotes 5 months ago

The conversation is about future hair loss treatments. Current treatments mentioned include finasteride, minoxidil, and RU58841, with potential future treatments like GT20029, TDM-105795, JW0061, and follicle cloning.

community Tom Cruise at the Mission Impossible premiere hair.(He's 61 y/o)

GOTdatSmack in Chat 392 upvotes 11 months ago

The conversation speculates on whether Tom Cruise uses hair loss treatments like Finasteride or Dutasteride, with some suggesting he naturally has good hair like Brad Pitt, while others joke about Scientology or genetics playing a role. Specific treatments mentioned include Finasteride, Dutasteride, and possibly high-quality hair products or procedures like PRP (Platelet-Rich Plasma).

community Last resort attempt. Studies suggest that finasteride topically actually inhibits up to 52% scalp dht which is smiles to dut 0.5mg daily. This solution contains: fin, min, melatonin and progesterone. Trial started today.

Combfromhell in Research/Science 8 upvotes 2 years ago

The conversation discusses a last-resort hair loss treatment combining topical finasteride, minoxidil, melatonin, and progesterone, with claims that topical finasteride can inhibit up to 52% of scalp DHT. One reply clarifies that progesterone is not an anti-androgen but has anti-androgenic properties because it competes with androgens for receptors.

community [study analysis] Microdose of topical Finasteride for all the benefits and none of the sides?

rapacal in Research/Science 104 upvotes 4 years ago

Topical finasteride as a potential alternative to oral finasteride for reducing DHT levels on the scalp with fewer side effects, and other hair loss treatments such as minoxidil.

community If Minoxidil Beards are permanent, why should Finasteride be unable to keep Minoxidil Gains on the scalp?

sziyo in Minoxidil 104 upvotes 2 years ago

Whether Finasteride can keep alive the hair gained by Minoxidil after quitting it, and why beard hairs are not as susceptible to miniaturization. It is suggested that scalp hair may be dependent on Minoxidil and that DHT could be countered with Finasteride to some extent, but there is no definitive data proving this.

community Short Term Fin awaiting advances in medical technology.

Long-Collection-251 in Finasteride/Dutasteride 36 upvotes 1 year ago

The user's consideration of taking finasteride as a short-term treatment, while awaiting advances in medical technology such as Pyrilutamide and GT20029; other users' experiences with Finasteride, including potential side effects.

community Do some people respond better to finasteride than dutasteride? Or the other way around?

Kindly-Scarcity7592 in Finasteride/Dutasteride 20 upvotes 1 year ago

The post and conversation are about the effectiveness of finasteride and dutasteride for hair loss. The conclusion is that the user had better results with finasteride and experienced rapid balding after switching to dutasteride.

community I’ve lost about 50% of my hair in 5 months. This is after 2 years of fin

LowSky8897 in Finasteride/Dutasteride 16 upvotes 10 months ago

The user is experiencing significant hair thinning and scalp discomfort after two years on finasteride and is considering switching to dutasteride. Another person suggests that scalp inflammation might be the cause and recommends a YouTube channel for more information.