Glycine supplementation may increase 5-alphareductase activity, potentially affecting hair loss. Users discuss its impact on hair fall and its role in the body.
The post discusses using a topical tincture containing zinc, azelaic acid, and other ingredients to inhibit 5alpha-reductase activity for treating hair loss. The user plans to try this natural alternative before using finasteride or RU58841.
The conversation is about determining which type of Saw Palmetto, either Chamaerops humilis or Serenoa repens, is effective for inhibiting the 5alphareductase enzyme related to hair loss. Specific treatments mentioned are Minoxidil, finasteride, and RU58841.
The post is a humorous take on the author's experience with hair loss and using finasteride for six months. The conversation includes discussions about hair loss, treatments like finasteride, and personal experiences with baldness.
The conversation discusses how different factors can stimulate type 1 and type 2 isoforms of 5-alphareductase, which are enzymes linked to hair loss. Specific treatments mentioned include oral Dutasteride and topical Finasteride.
GHK-Cu is a potent inhibitor of the type 1 5-alphareductase enzyme in hair follicles, which may reduce hair loss without the side effects associated with type 2 5-alphareductase inhibitors. The user previously experienced side effects with 5-alphareductase inhibitors and is considering GHK-Cu as an alternative.
The conversation is about managing allopregnanolone deficiency caused by 5-alpha-reductase inhibitors like finasteride or dutasteride. Specific treatments discussed for hair loss include Minoxidil, finasteride, and RU58841.
The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5alphareductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.
A 19-year-old male has been using minoxidil 5% and dermarolling for four months to treat hair loss, applying minoxidil twice daily and dermarolling once a week. Commenters suggest consistent treatment, improving picture quality, and adding a 5-alpha-reductase inhibitor to enhance results.
FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
The conversation discusses using zinc sulphate and azelaic acid to inhibit 5alpha-reductase activity, which could potentially treat androgen-related skin conditions like hair loss. Combining these with vitamin B6 could enhance the effect, potentially offering an alternative to finasteride.
He Shou Wu (Fo Ti) extract was found to prolong the hair growth phase, inhibit 5-alpha-reductase (like finasteride), reduce androgen receptors, and increase growth factors, potentially outperforming minoxidil in recovering hair follicle size after DHT exposure. Two compounds, emodin and TSG, are identified as responsible for these effects and warrant further investigation.
A user asked if microneedling, massages, and essential oils can prevent further hair loss in the crown area without using drugs. The response indicated that without a 5-alpha-reductase inhibitor, hair loss will likely continue.
The conversation discusses a user's two-month hair regrowth progress using Minoxidil and a 0.5mm dermaroller. Some suggest adding a 5-alpha-reductase inhibitor like finasteride or dutasteride to maintain the results.
The impact of creatine on DHT levels, and whether it could cause accelerated male pattern baldness (MPB). The user taking a 5alphareductase inhibitor found that their DHT levels actually reduced despite taking creatine for nine weeks. Replies suggested looking into testosterone levels as well and debating the safety of creatine use in relation to MPB.
The conversation discusses natural DHT blockers like rice bran oil, which may reduce 5α-reductase activity similarly to Minoxidil and Dutasteride. One user argues that finasteride is more reliable and effective than natural alternatives.
A 19-year-old with rapid hair loss since 16 is considering a hair transplant but refuses to take finasteride or any 5α-Reductase inhibitors. They are currently using minoxidil, tretinoin, and microneedling with a Derminator 2, and only want hair until age 27.
The conversation is about a user's hair regrowth after 2.5 months using topical minoxidil. Some suggest adding finasteride for long-term results, while others share their experiences with side effects or alternative treatments like dermarolling and dietary improvements.
The user transitioned from finasteride to Cyproterone and started using Minoxidil, resulting in healthier hair and regrowth. They plan to wean off Minoxidil in a year, depending on regrowth.
A user shared their 10.5-month progress using oral finasteride, topical minoxidil, a derma roller, biotin, and Omega 3, despite losing over 150 hairs daily. They also mentioned starting "bald showers" after leg workouts for the last two months.
A user shared progress pictures after 15 months on 0.5 mg finasteride, reporting significant hair regrowth starting around 9 months. They no longer see the need for a hair transplant.
Finasteride can continue to improve hair loss for up to 10 years, with the best results seen when started early. Combining treatments like minoxidil, dermarolling, or RU58841 may enhance effectiveness.
The conversation discusses a prescribed hair loss treatment combining 12.5% minoxidil with tretinoin, azelaic acid, and topical finasteride, costing $55 a month. One user criticizes the packaging for degrading tretinoin, another suggests it's an overpriced option and recommends topical dutasteride as an alternative due to its higher molecular weight and lower systemic absorption.
Asteride into your routine
In this conversation, the user Icy-Indication267 was asking when they should start finasteride to treat their hair loss, which had responded well to minoxidil after two months. Other users shared advice on incorporating micro-needling and topical finasteride into their routine for optimal results.
A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.
A 28-year-old man saw hair regrowth after 1.5 years using a topical treatment combining 0.3% finasteride and 6% minoxidil. He initially experienced anxiety with oral finasteride but had no side effects with the topical version.
The discussion revolves around the frequency of applying topical finasteride for hair loss treatment. The main question is whether applying it every 4-5 days could still be effective, given that its half-life in the scalp tissue is 5-6 days.
