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This study found that prenatal exposure to finasteride in rats disrupted male reproductive development, causing physical alterations such as delayed preputial separation and increased nipple retention.

In this study, researchers used a hypospadiac rat model to demonstrate abnormal genital development, similar to human penoscrotal hypospadias, highlighting the model's value for studying penile growth and differentiation.

Finasteride affects male rat genitalia development, causing abnormalities during specific pregnancy days.

This study found that prenatal exposure to finasteride in pregnant rats significantly disrupted male reproductive development, confirming its use as a positive control for androgen-related reproductive effects.

This study outlines a multidisciplinary approach to investigate primary amenorrhea, emphasizing the necessity to consider medical history, physical examination, and potential hormonal or anatomical causes, and recommends early referral in cases of chromosomal abnormalities or persistent amenorrhea following the development of secondary sexual characteristics.