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Reduced Cardiotoxicity and Comparable Efficacy in a Phase III Trial of Pegylated Liposomal Doxorubicin HCl (CAELYX/Doxil) Versus Conventional Doxorubicin for First-Line Treatment of Metastatic Breast Cancer

research Reduced cardiotoxicity and comparable efficacy in a phase IIItrial of pegylated liposomal doxorubicin HCl(CAELYX™/Doxil®) versus conventional doxorubicin forfirst-line treatment of metastatic breast cancer

1461 citations , March 2004 in “Annals of oncology”

This study found that in first-line treatment of metastatic breast cancer, pegylated liposomal doxorubicin (PLD) provided similar progression-free survival to doxorubicin with significantly less cardiotoxicity.

Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

research Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with the Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society

815 citations , April 2010 in “The Journal of Clinical Endocrinology & Metabolism”

This review examines the relationship between polycystic ovary syndrome and cardiovascular disease risk, but reports no new clinical findings; the panel calls for guidelines to prevent CVD in this population.

research Polycystic Ovary Syndrome and Cardiovascular Disease: A Premature Association?

418 citations , June 2003 in “Endocrine Reviews”

This review discusses the relationship between polycystic ovary syndrome and cardiovascular risk, noting a possible adverse impact on risk profiles and subclinical atherosclerosis but no clear increase in premenopausal cardiovascular events; it presents no new clinical results.

research Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair

248 citations , November 2011 in “The EMBO Journal”

This study found that Wnt1/βcatenin signaling plays a crucial role in activating the epicardium and cardiac fibroblasts, which supports cardiac repair following acute ischemic injury.

research Diabetes and cardiovascular events in women with polycystic ovary syndrome: a 20-year retrospective cohort study

150 citations , October 2012 in “Clinical Endocrinology”

In this retrospective cohort study, women with polycystic ovary syndrome showed high incidence and age-specific prevalence rates of type 2 diabetes, myocardial infarction, and angina, particularly in those over 65.

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community Cardio for more than 60 minutes reduces DHT levels and improve hair growth

in Research/Science 126 upvotes 1 year ago

Long aerobic exercise (over 60 minutes) can reduce DHT levels and improve hair health. Some users discuss using Tadalafil (Cialis) to further reduce DHT after exercise, while others mention using treatments like Minoxidil, Finasteride, and RU58841 for hair growth.

community I experienced severe cardiac and renal side effects with only 1.25 mg of minoxidil

942 upvotes 3 weeks ago

A 26-year-old male experienced severe cardiac and renal side effects, including heart palpitations and bigeminy, after taking a single 1.25 mg dose of oral minoxidil. Despite skepticism from others, medical tests confirmed these symptoms were linked to the medication.

community Anyone interested in a $50 gift card from Musely?

in Chat 6 upvotes 1 year ago

The conversation discusses hair loss treatments, specifically mentioning Exosomes, Minoxidil, Finasteride, and RU58841. The user offers $50 gift cards for new Musely customers.

community Heart Palpitations: Oral Minoxidil or Cardio?

2 upvotes 2 weeks ago

The user experienced heart palpitations after starting oral minoxidil and wonders if it's due to increased cardio activities or the medication. Other users suggest it might be a side effect of minoxidil, with some sharing similar experiences, and recommend consulting a doctor.

community The dose dependent nature of the cardiac effects RU58841

5 upvotes 8 months ago

Reducing the dose of RU58841 from 25mg to 7.5mg topically helped minimize heart palpitations. Users discussed the cardiac effects of RU58841 and minoxidil, noting that no treatment is completely free of side effects.

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