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research Novel Progestogenic Androgens for Male Contraception: Design, Synthesis, and Activity of C7 Alpha-Substituted Testosterone

September 2023 in “Biology of reproduction”

New testosterone analogs show promise for male contraception with better activity and potentially fewer side effects.

research The Androgen Receptor and Its Use in Biological Assays: Looking Toward Effect-Based Testing and Its Applications

22 citations, November 2011 in “Journal of Analytical Toxicology”

Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.

research Effects of the Anti-Androgen Finasteride on 5-Alpha-Reductase Activity in Human Gingival Fibroblasts in Response to Minocycline

15 citations, January 1998 in “Journal of Clinical Periodontology”

Finasteride helps treat hair loss by blocking enzyme activity.

research The Effect of Minocycline on the Metabolism of Androgens by Human Oral Periosteal Fibroblasts and Its Inhibition by Finasteride

10 citations, April 2000 in “Archives of Oral Biology”

Minocycline may cause hair loss by increasing DHT levels, but finasteride can help counteract this effect.

research Improving Selective Androgen Receptor Modulator Discovery and Preclinical Evaluation

11 citations, August 2009 in “Expert Opinion on Drug Discovery”

We need better ways to test and understand SARMs to make safer and more effective treatments.

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Community Join

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community Insane dutasteride shed 4 months after switching.

in Finasteride/Dutasteride 115 upvotes 1 year ago

The post and conversation are about a user's experience with hair loss treatments, specifically switching from finasteride to dutasteride. The user experienced significant hair shedding after the switch, with others suggesting patience, noting similar experiences, or questioning the user's decision and medical consultation.

community Estrogen is an anabolic for scalp hair, if you mix it with growth stimulants such as oral minoxidil. All we need is an artificial SARM-estrogen that will work only with hair and will be invisible for the rest of the body + some next level AA only for hair – goodbye hair transplant industry

in Transgender 137 upvotes 3 years ago

Hair loss discussion mentions using estrogen mixed with growth stimulants like oral minoxidil for scalp hair growth. Idea proposed for an artificial SARM-estrogen that only affects hair without body side effects.

community Trestolone (MENT) as a nuclear treatment

in Treatment 99 upvotes 2 years ago

Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

community Aromatase Upregulation along with DHT down regulation could possibly hold the cure

in Microneedling 7 upvotes 2 years ago

The post discusses the potential of upregulating aromatase to treat hair loss, suggesting that increasing CCL2 levels through Vitamin D or microneedling might help. The user questions why microneedling doesn't work for everyone, especially those with advanced hair loss.

community A warning to those thinking about using Dutasteride

in Finasteride/Dutasteride 99 upvotes 4 years ago

The potential risks of long-term use of Dutasteride and how it may be linked to elevated liver enzymes, cholesterol levels, and decreased testosterone. Alternative treatments such as Finasteride and RU58841 were also discussed.

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