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Aminopterin strongly suppresses epithelial tissues and can treat certain skin conditions but has significant side effects.

Aminopterin was somewhat effective in acute lymphoblastic leukemia in children but did not increase survival time.

Aminopterin effectively improves skin conditions but has toxic side effects that need careful monitoring.

Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Colchicine causes rapid hair loss by damaging hair follicles.