research The Rational Role Of Polyamines In Epidermal Differentiation
The study by Rahim et al. (2021) demonstrated that the balance of polyamine ratios, specifically the reduction of putrescine and increase of spermine regulated by AMD1, played a critical role in keratinocyte differentiation and epidermal homeostasis. This shift was essential for managing hyperproliferative skin disorders like psoriasis and skin cancer. The research suggested that activating AMD1 could be a promising therapeutic strategy, highlighting the importance of focusing on polyamine balance rather than total levels in treating these conditions.
