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research Structure Optimization of Tetrahydropyridoindole-Based Aldose Reductase Inhibitors Improved Their Efficacy and Selectivity

13 citations , October 2017 in “Bioorganic & Medicinal Chemistry”

Optimizing the structure of a specific compound greatly improved its effectiveness and precision for treating diabetic complications.

Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors and Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

research Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors and Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

9 citations , May 2021 in “Molecules”

New indole-based compounds, particularly cemtirestat, show promise as dual-function drugs for diabetic complications.

research Does Inhibition of Aldose Reductase Contribute to the Anti-Inflammatory Action of Setipiprant?

6 citations , August 2017 in “Physiological Research”

Setipiprant may reduce inflammation by blocking an enzyme called aldose reductase.

Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of Quercus Acutissima Cortex

research Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of Quercus Acutissima Cortex

37 citations , January 2015 in “Evidence-based Complementary and Alternative Medicine”

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

research Baiting Proteins with C60

106 citations , April 2010 in “ACS Nano”

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

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community A science based addition to your hair loss routine

in Research/Science 23 upvotes 1 year ago

Blocking the Mitochondrial pyruvate carrier and using aldose reductase inhibitors like Indian gooseberry and berberine may help with hair growth. Magnesium can also be added to increase NADPH.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 479 upvotes 1 year ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community A New Therapeutic Channel to Come Soon: Hair Follicle Sugar Metabolism and Aldose Reductase

in Research/Science 132 upvotes 4 years ago

Hair loss therapies focusing on hair follicle sugar metabolism and aldose reductase. Potential treatments include magnesium supplements, avoiding high glycemic index foods, and antioxidants.

community Painkillers May Block Minoxidil

in Research/Science 12 upvotes 5 months ago

Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.