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Bridging Personal and Population in Excitability Diseases: Will Studies of Rare Diseases Bring Generalizable Mechanisms From Monogenic Channelopathies?

research Bridging Personal and Population in Excitability Diseases: Will Studies of Rare Diseases Bring Generalizable Mechanisms From Monogenic Channelopathies?

January 2022 in “Function”

Studying rare genetic disorders can help us understand and treat common diseases better.

Skin and Hair Abnormalities of Cantu Syndrome: A Congenital Hypertrichosis Due to a Genetic Alteration Mimicking the Pharmacological Effect of Minoxidil

research Skin and Hair Abnormalities of Cantu Syndrome: A Congenital Hypertrichosis Due to a Genetic Alteration Mimicking the Pharmacological Effect of Minoxidil

7 citations , January 2020 in “Journal of Dermatology”

Cantu syndrome, which causes excessive hair growth and skin issues, is due to a mutation in the ABCC9 gene, and understanding this could help develop new treatments for hair diseases.

research Cantú Syndrome with Coexisting Familial Pituitary Adenoma

14 citations , January 2018 in “Endocrine”

Cantú syndrome may be linked to pituitary adenomas.

research Cantú Syndrome Is Caused by Mutations in ABCC9

148 citations , May 2012 in “The American Journal of Human Genetics”

Cantú syndrome is caused by mutations in the ABCC9 gene.

research Glyburide Blocks the Relaxation Response to BRL 34915 (Cromakalim), Minoxidil Sulfate, and Diazoxide in Vascular Smooth Muscle

90 citations , January 1989 in “PubMed”

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Community Join

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community Oral Min is much better than topical

in Minoxidil 182 upvotes 1 year ago

Oral minoxidil is seen as more effective and convenient than topical minoxidil for hair regrowth, but it may cause heart-related risks. Users often combine it with finasteride or dutasteride, though some prefer topical treatments due to safety concerns.

community Being Safe on Oral Minoxidil: tl;dr on the literature.

in Research/Science 50 upvotes 1 year ago

Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.

community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

nkrata in Research 461 upvotes 9 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.