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Key Targets of Hormonal Treatment of Prostate Cancer: The Androgen Receptor and 5α-Reductase

research Key targets of hormonal treatment of prostate cancer. Part 2: the androgen receptor and 5α-reductase

29 citations , July 2009 in “BJU international”

This review examines the pharmacological properties and potential clinical benefits of 5α‐reductase inhibition in prostate cancer but reports no new research findings.

research Melatonin Promotes Human Hair Follicle Stem Cell Proliferation by Suppressing 5-AR: Implications for Treating Androgenetic Alopecia

July 2026 in “Journal of Craniofacial Surgery”

This study found that silencing SRD5A2 and applying melatonin significantly boosted proliferation and migration of human hair follicle stem cells without causing differentiation, while increasing MT1 expression and reducing 5-alpha-reductase levels.

research Synthesis and Study of Some 17a-aza-D-homo Steroids as 5α-Reductase Inhibitors

1 citations , October 2020 in “Current Drug Discovery Technologies”

This study investigated various synthesized 5-reductase inhibitors and found that compound 6 had the highest anti-androgenic activity and receptor affinity compared to finasteride, showing potential due to its improved efficacy and bioavailability for further research in treating lower urinary tract symptoms.

research Isolation rearing-induced reduction of brain 5α-reductase expression: Relevance to dopaminergic impairments

48 citations , January 2011 in “Neuropharmacology”

Isolation stress in rats reduces brain enzyme levels, affecting dopamine function.

research Genetic and molecular aspects of androgenetic alopecia

24 citations , January 2018 in “Indian Journal of Dermatology, Venereology and Leprology”

This review discusses advances in molecular biology and genetics related to androgenetic alopecia and reports no new clinical results.

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community Is there any role for topical DHT antagonists, or does a 5-AR inhibitor remove the need for them as therapy

2 upvotes 1 year ago

Topical androgen receptor antagonists may not be necessary if 5-AR inhibitors like finasteride or dutasteride effectively reduce DHT levels. Combining a 5-AR inhibitor with a topical androgen antagonist could potentially enhance treatment, but oral use of androgen antagonists is too risky due to severe side effects.

community Minoxidil is a 5ar inhibitor according to research

150 upvotes 11 months ago

Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.

community Clascoterone 5% Delivers Strong Phase 3 Hair-Growth Results

371 upvotes 8 months ago

Clascoterone 5% solution shows strong potential for hair growth, offering a new treatment for alopecia with minimal side effects. It blocks androgen receptors locally and may be available by late 2026 or early 2027.

community Fluridil degrades the androgen receptor.

in Research/Science 12 upvotes 1 year ago

Fluridil degrades androgen receptors, which are prevalent in the scalp and other tissues. People with androgenetic alopecia (AGA) may have higher expression of these receptors and 5AR activity in affected scalp areas.

community Breezula Phase 3 Results enough for maintenance?

13 upvotes 4 months ago

Breezula shows promise in stabilizing hair loss and potentially promoting regrowth at the one-year mark, offering hope for those who can't tolerate 5AR inhibitors. Its local targeting of androgen receptors could be a significant advancement if it avoids systemic side effects.

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