The KRAB Domain Zinc Finger Protein, Zfp157, Is Expressed in Multiple Tissues During Mouse Embryogenesis and in Specific Cells in Adult Mammary Gland and Skin
January 2013
in “
genesis
”
TLDR Zfp157 is active in many mouse tissues during development and in specific adult cells.
The study identified Zfp157, a KRAB domain zinc finger protein, as a downstream target of the transcription factor Stat6 in the mammary gland. Researchers used a gene-trap approach to generate mice with a Zfp157-LacZ reporter gene, allowing them to track its expression during mouse embryogenesis. Zfp157 was found to be expressed in various embryonic tissues, including the brain, ovary, intestine, kidney, lung, mammary gland, and hair follicle. In adult mice, Zfp157 expression persisted across multiple tissues, with specific patterns observed in the mammary gland's basal epithelial cells and the sebaceous glands of hair follicles. This research provided a basis for further investigation into the function of Zfp157.
