Ejaculatory Dysfunction in the Treatment of Lower Urinary Tract Symptoms

August 2016 in “ Translational Andrology and Urology ”

Kenneth J. DeLay, Max Nutt, Kevin T. McVary

5-alpha reductase inhibitors alpha blockers transurethral resection of the prostate benign prostatic hyperplasia ejaculatory dysfunction endothelial dysfunction autonomic hyperactivity TURP BPH EjD

Studysummary This review discusses the impact of medical and surgical treatments for LUTS/BPH on ejaculatory function, highlighting that most treatments negatively affect it, except for some minimally invasive surgical therapies and specific medical therapies.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The review article examined the link between treatments for lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) and the risk of ejaculatory dysfunction (EjD). It was found that both medical and surgical treatments for LUTS often increased the risk of EjD. Specifically, transurethral resection of the prostate (TURP) resulted in EjD in 65% of patients. Medical treatments, such as alpha blockers and 5-α reductase inhibitors, also contributed to EjD, with alpha blockers frequently causing anejaculation. The article stressed the importance of patient counseling about these risks and noted that while less invasive therapies might preserve ejaculatory function, they could be less effective in alleviating LUTS. The pathophysiology of EjD was associated with endothelial dysfunction and autonomic hyperactivity.

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