Xerostomia as a Rare Adverse Effect of Low-Dose Oral Minoxidil: A Case Report With Recurrence After Rechallenge

    September 2025 in “ Clinical Case Reports
    Nicolò Rivetti
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    TLDR Oral minoxidil can cause dry mouth, but switching to topical minoxidil may prevent this side effect.
    Oral minoxidil, used for treating hair loss, can cause xerostomia (dry mouth) as a rare side effect, as demonstrated in a 74-year-old woman. Her symptoms resolved after stopping the medication and recurred upon reexposure, indicating a causal relationship. This case highlights the need for clinicians to consider dry mouth as a potential systemic reaction to oral minoxidil, even at low doses. The patient successfully switched to topical minoxidil without experiencing xerostomia again, suggesting that topical formulations may be a safer alternative for those predisposed to salivary gland dysfunction.
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      community Oral minoxidil causes me stronger heart beat

      in Minoxidil  64 upvotes 1 month ago
      Oral minoxidil can cause a stronger heartbeat, which may lessen over time, but if it persists or worsens, consulting a professional is advised. Reducing the dose or switching to a topical form might help.

      community Oral Minoxidil Secret Very important

      in Minoxidil  237 upvotes 2 months ago
      Oral minoxidil can cause side effects like shortness of breath and constipation, which may be reduced by taking it in the morning. Some users experience no side effects, while others switch to topical treatments or adjust their dosage and timing to manage symptoms.

      community Oral minoxidil vs Topical Minoxidil w/ Retinoic acid

      in Minoxidil  7 upvotes 2 months ago
      Topical minoxidil with retinoic acid is effective but causes scalp irritation, leading the user to consider switching to 2.5mg oral minoxidil. Oral minoxidil may cause body hair growth and heart-related side effects, so it's advised to use it under medical guidance.

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