Wnt10a as a Candidate for Induction of Dental Pulp Regeneration with Dentine-Inducing Capacity

This study investigates the role of Wnt10a in dental pulp regeneration and its potential as a non-cellular agent for inducing dentine formation. The research involved transplanting dental pulp, bone marrow, adipose stem cells, or their culture supernatants in an ectopic tooth model, successfully regenerating dental pulp tissue expressing the marker TRH-DE. The study found that odontoblasts, which express Wnt10a, increased with dental pulp regeneration. Additionally, inhibiting DKK1 expression led to increased DSPP expression, promoting dentinal differentiation through Wnt10a. These findings suggest that Wnt10a could be a promising agent for dental pulp regeneration with dentine-inducing capacity.