The Financing of the Water Cycle in the Flemish Region

    January 2005 in “ Psychoneuroendocrinology ”
    Christian Legros, Marc Buysse
    TLDR Finasteride may affect brain chemistry and behavior, offering potential for treating certain mental health conditions.
    The study investigated the effects of finasteride (FIN), a 5α-reductase inhibitor used for androgenic alopecia and benign prostatic hyperplasia, on neuropsychiatric conditions. In rat models, FIN was found to block dopamine receptor effects in the nucleus accumbens, a key area in the dopamine mesolimbic system. Proteomic analysis revealed significant changes in the expression of nine proteins following FIN treatment, suggesting potential new chemical targets and providing insights into the drug's behavioral effects and therapeutic potential for conditions like Tourette syndrome and schizophrenia. The study involved a small sample size of 5 rats per group.
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