Vitamin D receptor polymorphisms and the polycystic ovary syndrome: A systematic review

The document is a systematic review of studies exploring the association between vitamin D receptor (VDR) polymorphisms and polycystic ovary syndrome (PCOS). The review, which included 11 studies published between 2009 and 2015, found inconsistent results. Some studies reported associations between specific VDR polymorphisms and PCOS or related traits like insulin resistance, while others found no significant associations. For example, the 'CC' genotype of the FokI polymorphism was linked to an increased risk for insulin resistance and higher serum insulin levels. The review also noted that certain genotypes might be associated with PCOS severity or metabolic parameters, such as BMI and testosterone levels. However, the overall evidence did not conclusively link VDR polymorphisms with PCOS risk or severity. The review concluded that more research is needed to fully understand the relationship between VDR polymorphisms and PCOS, and it suggested that vitamin D levels might have a more significant impact on PCOS features than VDR polymorphisms, with vitamin D supplementation potentially beneficial in managing PCOS symptoms.