Increased Risk of Vitamin D Deficiency and Insufficiency in Black Patients With Central Centrifugal Cicatricial Alopecia

A retrospective chart review of 54 Black patients diagnosed with central centrifugal cicatricial alopecia (CCCA) at a specialty alopecia clinic found a significant relationship between vitamin D deficiency (VDD) and insufficiency (VDI) and CCCA. Of the 27 patients who met the inclusion criteria, 92.5% had VDD or VDI. Compared to Black individuals in the general population, Black patients with CCCA had over 5 times increased odds of having VDD or VDI (odds ratio = 5.43; 95% CI, 5.43-177.63; P = .0018) and a significantly higher prevalence of VDD and VDI (92.6% vs 69.7%, P < .001). Notably, 89% of the patients with VDD or VDI had a CCCA severity score of 3 or higher. The study suggests future research should investigate the relationships between the severity of VDD and the severity of hair loss in Black patients with CCCA within a larger population.