Uveodermatological Syndrome Associated With Alopecia Areata in a One-Year-Old Female Spayed Cavalier King Charles Spaniel Dog

October 2024 in “ Veterinary Dermatology ”

Barbara Mcmahill, Sophie Gilbert, Jamie L. Haddad, Janelle Novak, Maria Shank, Verena K. Affolter

alopecia areata uveodermatological syndrome autoimmune disorders inflammation hair loss

TLDR A Cavalier King Charles Spaniel had both uveodermatological syndrome and alopecia areata, and treatment with ciclosporin helped regrow hair.

This case study reports the first known instance of concurrent uveodermatological syndrome (CUDS) and alopecia areata (AA) in a 1.5-year-old Cavalier King Charles Spaniel. Both are autoimmune disorders, with CUDS affecting ocular and skin tissues and AA causing hair loss. The dog presented with bilateral uveitis and progressive alopecia, particularly in black-haired areas. Histopathological analysis showed lymphocytic and histiocytic inflammation in ocular and skin tissues. Treatment with ciclosporin resulted in significant hair regrowth and repigmentation, although side effects required dosage adjustments. The study suggests a potential link between CUDS and AA due to shared autoimmune mechanisms targeting melanocytes, similar to human cases, and emphasizes the importance of recognizing this association in veterinary dermatology for improved treatment strategies.

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Research cited in this study

2 / 2 results

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