Ultrastructural Localization of S100A3, a Cysteine-rich, Calcium Binding Protein, in Human Scalp Hair Shafts Revealed by Rapid-freezing Immunocytochemistry

    April 1999 in “ Journal of Histochemistry & Cytochemistry ”
    Takami Takizawa, Toshihiro Takizawa, Seiichi Arai, Kenji Kizawa, Hideyo Uchiwa, Ichiro Sasaki, Takafumi Inoue
    TLDR S100A3 protein is mainly found in specific parts of human hair cells.
    The study characterized the subcellular distribution of S100A3, a cysteine-rich calcium-binding protein, in human scalp hair shafts using rapid-freezing immunocytochemistry. This method preserved the antigenicity and ultrastructural integrity of keratinized tissues. S100A3 was primarily located in the endocuticle and the intermacrofibrillar matrix of cortex cells, with a specific spatial relationship to hair keratins. This research provided the first ultrastructural evidence of S100 protein localization in specific subcompartments of human hair cells.
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