Two Siblings With Vitamin-D-Dependent Rickets Type II: No Recurrence Of Rickets For 14 Years After Cessation Of Therapy

October 1989 in “ European Journal of Pediatrics ”

Eiji Takeda, Ichiro Yokota, Ikuo Kawakami, Tadashi Hashimoto, Yuichi Kuroda, Seiji Arase

TLDR Two siblings stayed rickets-free for 14 years after stopping treatment.

The document described two siblings with vitamin-D-dependent rickets type II who did not experience a recurrence of rickets for 14 years after stopping therapy. This suggests that long-term remission is possible in such cases, even after the cessation of treatment.

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research Vitamin D-Dependent Rickets Type II: Extreme End Organ Resistance to 1,25-Dihydroxy Vitamin D3 in a Patient Without Alopecia

50 citations, October 1986 in “European journal of pediatrics”

A boy with severe Vitamin D-resistant rickets did not respond to treatment and lacked a common symptom, suggesting a need for alternative treatments.

research 1,25-Dihydroxyvitamin D Resistance, Rickets, and Alopecia

110 citations, November 1984 in “The American Journal of Medicine”

A genetic defect in vitamin D receptors causes severe rickets and hair loss in children, but some heal as they age.

research Rickets and Alopecia with Resistance to 1,25-Dihydroxyvitamin D: Two Different Clinical Courses with Two Different Cellular Defects

88 citations, October 1983 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Patients with this syndrome can have different responses and worsening resistance to treatment over time.