Trichoscopy in Anagen Effluvium: Extensive Peripilar Sign

The document presented two cases of anagen effluvium, a condition of rapid hair loss, where the peripilar sign was extensively seen on trichoscopy. The peripilar sign, also known as perifollicular hyperpigmentation or brown perifollicular discolouration, is a brown halo surrounding a hair follicle, often seen in conditions like androgenetic alopecia and telogen effluvium. It was suggested that the occurrence of peripilar sign in anagen effluvium could be due to perifollicular inflammation caused by ultraviolet rays, chemical exposure, or melanocytes. The patients in the study, who were Asian, had undergone intensive chemotherapy resulting in anagen effluvium, and it was speculated that prolonged chemical exposure could be a causative factor for peripilar sign in anagen effluvium. This was the first report of peripilar sign in anagen effluvium, but further evaluation was needed to understand its origin and prognostic significance.