TLDR Oclacitinib maleate successfully treated alopecia in Andean bears.
The study described the successful treatment of alopecia syndrome in three female Andean bears using oclacitinib maleate (Apoquel®). The bears exhibited symptoms such as symmetrical flank alopecia, pruritus, and secondary infections. Previous treatments, including diet trials, antifungals, antihistamines, and immunotherapy, were ineffective. However, oclacitinib maleate led to rapid and complete resolution of pruritus and significant fur regrowth within 5 months, with no adverse effects noted. This treatment was tapered to the lowest effective dose to prevent relapse. The study highlighted the need for further research on the etiology of the syndrome and the long-term safety of oclacitinib.
51 citations,
June 2016 in “Journal of the European Academy of Dermatology and Venereology” Tofacitinib was effective in treating hair loss in two patients with alopecia universalis.
70 citations,
April 2016 in “Experimental Dermatology” A patient with alopecia areata regrew hair after taking tofacitinib and showed changes in certain blood and skin markers.
184 citations,
February 2015 in “EBioMedicine” A patient with Alopecia Areata had complete hair regrowth after using the drug baricitinib.
December 2019 in “Pubvet” The document concludes that atopic dermatitis in dogs is managed with various treatments including antipruritics, supplements, and possibly immunotherapy.
19 citations,
April 2019 in “Veterinary dermatology” Oclacitinib effectively treated a skin condition in dogs that didn't respond to other immunosuppressants.
June 2018 in “Acta Scientiae Veterinariae” Tailored treatment plans are crucial for managing canine dermatomyositis-like disease.
77 citations,
June 2017 in “Advances in Therapy” New treatments for Alopecia Areata, like JAK inhibitors, show promise for hair regrowth and are likely to change future treatment approaches.
30 citations,
May 2016 in “Expert Opinion on Biological Therapy” New treatments targeting immune pathways show promise for severe hair loss but need more research for safety and effectiveness.
