Treatment Success in Three Andean Bears (Tremarctos Ornatus) with Alopecia Syndrome Using Oclacitinib Maleate (Apoquel)

The study described the successful treatment of alopecia syndrome in three female Andean bears using oclacitinib maleate (Apoquel®). The bears exhibited symptoms such as symmetrical flank alopecia, pruritus, and secondary infections. Previous treatments, including diet trials, antifungals, antihistamines, and immunotherapy, were ineffective. However, oclacitinib maleate led to rapid and complete resolution of pruritus and significant fur regrowth within 5 months, with no adverse effects noted. This treatment was tapered to the lowest effective dose to prevent relapse. The study highlighted the need for further research on the etiology of the syndrome and the long-term safety of oclacitinib.