Tooth tissue and organ regeneration using stem cells

The document reviewed the potential of regenerative therapy for tooth tissue repair and whole-tooth replacement using mesenchymal stem cell-like types identified in oral tissues. These cells were capable of differentiating into tooth tissues both in vitro and in vivo. A novel organ germ method was developed to mimic organogenesis by compartmentalizing epithelial and mesenchymal cells, leading to the creation of bioengineered tooth germs that could generate structurally correct teeth. These bioengineered teeth, when transplanted into the oral cavity, successfully erupted and integrated with the jaw, performing essential functions such as mastication and responding to stimuli. The study highlighted the promise of stem cell-based therapies in tooth regeneration.